Wound healing
AssigneeThe Regents of the University of California
InventorsManuela Martins-Green, Sandeep Dhall, Danh Do, Neal Schiller
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Abstract
A method of treating a chronic wound in a subject in need of such treatment is provided. The method includes administering to the subject at least one antioxidant agent in an amount effective to treat the wound. In some versions, the antioxidant agent is α-tocopherol or N-acetyl cysteine, or a combination of these compounds. In other versions, a method of preparing a chronic wound animal model is provided.
Claims12
A method of treating a mouse to cause it to have a chronic wound whereby the mouse can be used as an animal model, comprising
- creating a fresh wound in a mouse,
- inhibiting at least two antioxidant agents located within the fresh wound, and
- allowing the fresh wound to develop into a chronic wound,
- wherein the inhibiting is performed by administering to the mouse one or more inhibitors of the at least one antioxidant agent, where the one or more inhibitors is an inhibitor of catalase, an inhibitor of glutathione peroxidase, or a combination thereof.
A method of screening for an agent that treats chronic wounds, comprising screening a compound for its ability to reduce or heal a chronic wound of an animal model, wherein the animal model results from treating a mouse to cause it to have a chronic wound whereby the mouse can be used as an animal model, comprising:
- creating a fresh wound in a mouse,
- inhibiting at least two antioxidant agents located within the fresh wound, and
- allowing the fresh wound to develop into the chronic wound,
- wherein the inhibiting is performed by administering to the mouse one or more inhibitors of the at least one antioxidant agent, where the one or more inhibitors is an inhibitor of catalase, an inhibitor of glutathione peroxidase, or a combination thereof.
Dependencies are inferred from the claim text.