Panicein compounds, compositions and uses thereof

A method for treating a cancer, for reducing cancer metastasis and/or cancer recurrence in a subject comprising a step of administering to a subject a panicein compound in combination with at least one chemotherapeutic drug, wherein the cancer comprises cancer cells expressing the Patched receptor, and wherein the panicein compound is of formula (I)

• wherein:
• R1 is H, C1-C6 alkyl, C1-C6 aminoalkyl, C1-C6 hydroxyalkyl, C1-C6 halogenoalkyl or —OR4,
• R2 is H or C1-C6 alkyl,
• R3 is C1-C6 alkyl, —CH2OR4, —C(═O)R4, —C(═O)OR4, —C(═O)NHR4, or —CH2NHR4,
• each R4 is independently —H, or C1-C6 alkyl,
• R is:
• wherein:
• bonds (1) and (2) are independently of each other a single bond or a double bond and bonds (1) and (2) are not simultaneously double bonds,
• R5 is present when bond (1) is a single bond, and represents —H, or —OR6, and
• when present, each R6 is independently H or a C1-C6 alkyl;
• or a pharmaceutically acceptable salt thereof;
• and
• wherein cancer is selected from a melanoma, a breast cancer, a thyroid cancer, a prostate cancer, an esophagus cancer, a gastric cancer, an ovarian cancer, a pancreatic cancer, a glioma, an adrenocortical carcinoma, a leukemia, a multiple myeloma or a sarcoma;
• and
• wherein the at least one chemotherapeutic drug is selected from cisplatin, docetaxel, doxorubicin, methotrexate, temozolomide, 5-fluorouracil (5-FU), dacarbazine and vemurafenib.