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US 10,376,469 B2Granted
Microspheres containing therapeutic agents and related methods of use
AssigneeBiosphere Medical, Inc.
InventorPhilippe Reb
Life of this patent
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Abstract
Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.
Claims19
Microspheres suitable for use in therapeutic embolization, comprising:
- a biocompatible, polymeric material comprising a copolymer comprising an acrylamide monomer, wherein the acrylamide monomer is selected from N-[tris(hydroxymethyl)methyl]acrylamide and N,N′-methylenebis(acrylamide), and a cyclodextrin;
- and
- a therapeutic agent;
- wherein the microspheres comprise a biodegradable portion and a non-biodegradable portion, wherein the biodegradable portion comprises the cyclodextrin, and wherein the microspheres retain a substantially spherical shape after degradation of the biodegradable portion when placed in a patient's body.
1 more element
A method of embolization, comprising:
- administering to a patient microspheres comprising:
- a biocompatible, polymeric material comprising a copolymer comprising an acrylamide monomer, wherein the acrylamide monomer is selected from N-[tris(hydroxymethyl)methyl]acrylamide and N,N′-methylenebis(acrylamide), and a cyclodextrin;
- and
- a therapeutic agent, wherein the therapeutic agent comprises a platinum-based drug, a taxol, an anthracycline, or a campothecin,
- wherein the microspheres comprise a biodegradable portion and a non-biodegradable portion, wherein the microspheres retain a substantially spherical shape after degradation of the biodegradable portion when placed in a patient's body;
- occluding a blood vessel with the microspheres;
- and
- releasing the therapeutic agent.
5 more elements
A method of manufacturing microspheres, the method comprising:
- obtaining an aqueous solution comprising one or more acrylamide monomers selected from N-[tris(hydroxymethyl)methyl]acrylamide and N,N′-methylenebis(acrylamide), and an olefin-containing cyclodextrin;
- obtaining an oil;
- mixing the aqueous solution into the oil;
- and
- polymerizing the one or more acrylamide monomers and the olefin-containing cyclodextrin after the aqueous solution has been mixed into the oil;
- and
- isolating microspheres formed by the polymerization of the one or more acrylamide monomers and the olefin-containing cyclodextrin, wherein the microspheres comprise a biodegradable portion and a non-biodegradable portion, and wherein the microspheres are configured to retain a substantially spherical shape after degradation of the biodegradable portion when placed inside a patient's body.
4 more elements
Dependencies are inferred from the claim text.