Block copolymers and self-assembling nanoparticles formed therefrom
AssigneesInternational Business Machines Corporation, Institute of Bioengineering and Nanotechnology, Biomedical Sciences Institute
InventorsDylan Boday, Willy Chin, Mareva B. Fevre, Jeannette Garcia, James L. Hedrick, Eunice Leong, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang
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Abstract
The subject matter of this invention relates to block copolymers (BCPs) and, more particularly, to block copolymers capable of self-assembly into nanoparticles for the delivery of hydrophobic cargos. The BCPs include a hydrophobic block that contains a thioether functional group that is susceptible to oxidation, transforming the solubility of the block from hydrophobic to hydrophilic, thereby releasing the hydrophobic cargo of the nanoparticle.
Claims18
A block copolymer comprising:
- a hydrophilic block;
- and
- a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula I:
- wherein m is 114 and x is 5.
A block copolymer comprising:
- a hydrophilic block;
- and
- a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula I:
- wherein m is 228 and x is 10.
A block copolymer comprising:
- a hydrophilic block;
- and
- a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula II:
- wherein n is 114 and y is 10.
A block copolymer comprising:
- a hydrophilic block;
- and
- a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula II:
- wherein n is 228 and y is 10.
A block copolymer comprising:
- a hydrophilic block;
- and
- a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula III:
- wherein p is 114 and z is 5.
A block copolymer comprising:
- a hydrophilic block;
- and
- a hydrophobic block containing at least one thioether functional group, the block copolymer having the structure of formula III:
- wherein p is 228 and z is 5.
Dependencies are inferred from the claim text.