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US 10,376,465 B2Granted
Monovalent metal cation dry powders for inhalation
AssigneePulmatrix Operating Company, Inc.
InventorsMichael M. Lipp, Jean C. Sung
Life of this patent
Estimating the term…
Abstract
The present invention is directed toward respirable dry powders and particles for systemic delivery of pharmaceutically active agents or delivery to the respiratory tract. The dry powders contain one or more monovalent metal cations (such as Na+), are small and dispersible.
Claims7
A respirable dry powder comprising respirable dry particles that comprise sodium sulfate, leucine, an active agent, wherein said active agent is an anti-fungal, and an optional excipient;
- wherein the respirable dry powder comprising respirable dry particles is characterized by a volume median geometric diameter (VMGD) at 1 bar as measured using a HELOS/RODOS system between 0.5 microns and 5 microns, a tap density of greater than 0.4 g/cc to about 1.2 g/cc, and a dispersibility ratio of 1 bar/4 bar of about 1.5 or less.
Dependencies are inferred from the claim text.