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US 10,376,308 B2Granted
Devices and methods for treatment of heart failure by splanchnic nerve ablation
AssigneeAxon Therapies, Inc.
InventorsHoward Levin, Mark Gelfand
Life of this patent
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Abstract
A method for treating a heart failure patient by ablating a nerve of the splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method including: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects.
Claims33
A method for increasing splanchnic venous capacitance in a patient, comprising:
- positioning an endovascular catheter comprising a proximal region, a flexible shaft, and a distal region, wherein the flexible shaft connects the proximal and distal regions and is a length sufficient to access a T9, T10, or T11 intercostal vein of the patient relative to an access location when the proximal region remains external to the patient, and wherein the distal region is configured to be advanced through patient vasculature and dimensioned to terminate in the T9, T10 or T11 intercostal vein and make contact with an inner wall of the T9, T10 or T11 intercostal vein and comprises at least one ablation element, at least one stimulation element, and at least one detection element;
- advancing the distal region through an azygous vein;
- advancing the distal region from the azygous vein and into the T9, T10, or T11 intercostal vein;
- activating the at least one ablation element;
- ablating a greater splanchnic nerve using energy generated with the at least one ablation element;
- and
- removing the endovascular catheter from the patient.
4 more elements
A method for increasing splanchnic venous capacitance in a patient, comprising:
- positioning an endovascular catheter comprising a proximal region, a flexible shaft, and a distal region, wherein the flexible shaft connects the proximal and distal regions and is a length sufficient to access a T9, T10, or T11 intercostal vein of the patient relative to an access location when the proximal region remains external to the patient, the distal region comprising at least one ablation element;
- advancing the distal region through an azygous vein;
- advancing the distal region from the azygous vein and into the T9, T10, or T11 intercostal vein;
- activating the at least one ablation element;
- ablating a greater splanchnic nerve using energy generated with the at least one ablation element;
- and
- removing the endovascular catheter from the patient.
4 more elements
Dependencies are inferred from the claim text.