Transvascular and transcameral device access and closure

An occlusion system for transcatheter closure of a passageway in the cardiovascular system, comprising:

• an implant that is resiliently deformable into a radially compressed configuration for transcatheter delivery and radially self-expandable to an implanted configuration;
• the implant comprising a proximal end portion, a distal end portion, and an intermediate neck portion between the proximal end portion and the distal end portion;
• the implant configured to be implanted across a passageway in the cardiovascular system with the distal end portion positioned at a first end of the passageway, the proximal end portion positioned on a second, opposite end of the passageway, and the neck portion positioned in the passageway;
• wherein when implanted, the distal end portion of the implant is radially enlarged relative to the neck portion such that the distal end portion forms a distal skirt that contacts a wall of a cardiovascular chamber or vessel at the first end of the passageway and blocks blood flow from the cardiovascular chamber or vessel into the passageway;
• the implant further comprising a longitudinal guidewire channel extending through the proximal end portion, the neck portion, and the distal end portion of the implant, wherein the guidewire channel allows the implant to be delivered over a guidewire and the guidewire channel is configured to be occluded when a guidewire is not present in the guidewire channel;
• the occlusion system further comprising a detachable delivery system comprising an attachment member attached to a delivery shaft, wherein the attachment member is detachably couplable to the implant at an attachment location at a venous end of the guidewire channel, and wherein the delivery shaft and attachment member include a guidewire channel extending longitudinally therethrough such that the delivery system and the implant can be advanced over a guidewire extending through the guidewire channels in the delivery shaft, attachment member, and implant;
• wherein the delivery shaft terminates in a distal ball joint having flat opposing faces and the central guidewire channel extends entirely through the delivery shaft and through the distal ball joint, and the distal ball joint engages the attachment member such that the delivery shaft pivots in only one plane relative to the attachment member during positioning of the implant, and the delivery shaft is configured to transfer torque to the attachment member when the delivery shaft is rotated for selective attachment and detachment of the attachment member from the implant.