Manufacturing system for biopharmaceutical products

A method for quality assured manufacturing of at least two biopharmaceutical products in a manufacturing system, the manufacturing system comprising:

• a macro structure,
• at least two micro nodes and a network spine interconnecting the macro structure with each micro node, the macro structure comprising a warehouse facility and a hydration facility, and the at least two micro nodes representing inter-operationally discrete biopharmaceutical manufacturing facilities,
• wherein the macro structure and each micro node respectively each comprise a communication interface to the network spine,
• wherein the communication interface comprises a data interface arranged to receive culture media and/or buffer orders from at least one of the micro nodes and to return a materials delivery to the micro node in response to the received order, wherein verification of the materials delivery is performed prior to enabling delivery over a materials delivery interface,
• wherein a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of the network spine, the method comprising:
• obtaining, in the respective micro nodes, supply materials comprising customized culture media and/or buffer from the macro structure by means of the network spine;
• and
• processing, in each micro node, the supply materials to produce respective biopharmaceutical products.

A manufacturing system for quality assured manufacturing of at least two biopharmaceutical products, the manufacturing system comprising:

• a warehouse facility,
• a hydration facility, and
• at least two biopharmaceutical manufacturing facilities,
• wherein
• the warehouse facility and hydration facility are comprised in the macro structure,
• each biopharmaceutical manufacturing facility is comprised in a respective micro node, and
• a control facility, having a hardware processor, in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node,
• wherein the macro structure and each micro node respectively each comprise a communication interface to the network spine,
• wherein the communication interface comprises a data interface arranged to receive culture media and/or buffer orders from at least one of the micro nodes and to return a materials delivery to the micro node in response to the received order, wherein verification of the materials delivery is performed prior to enabling delivery over a materials delivery interface.

A computer program product comprising:

• at least one non-transitory computer readable storage medium having computer-executable program code instructions store therein, the computer-executable program code instructions comprising program code instructions configured to, when executed in a control facility of a macro structure:
• receive, from a micro node, a request for supply material, wherein the supply material comprises customized culture media;
• and
• control, in a hydration facility of the macro structure, preparation of the customized culture media,
• wherein the macro structure and the micro node respectively each comprise a communication interface to a network spine,
• wherein the communication interface comprises a data interface arranged to receive culture media and/or buffer orders from the micro node and to return a materials delivery to the micro node in response to the received order, wherein verification of the materials delivery is performed prior to enabling delivery over a materials delivery interface.