# US 10,371,966 B2 · Contact lens product

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- Number: US 10,371,966 B2
- Document ID: US10371966B2
- Status: Granted
- Kind: B2
- Application number: 15/401,142
- Filed: 2017-01-09
- Published: 2017-08-10
- Granted: 2019-08-06
- Earliest claimed: 2016-02-04
- Assignees: Largan Medical Co., Ltd.
- Applicants: Largan Medical Co., Ltd.
- Inventors: En-Ping Lin; Wei-Yuan Chen; Chun-Hung Teng
- Web page: https://patentgrep.com/patent/US10371966B2

## CPC

- G02C 7/104: {having spectral characteristics for purposes other than sun-protection}
- A61K 9/0051: {Ocular inserts or implants}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 38/168: {from plants}
- A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- G02B 1/043: {Contact lenses}
- G02C 7/04: Contact lenses for the eyes (disinfection or sterilisation of contact lenses A61L12/00)
- G02C 7/049: {Contact lenses having special fitting or structural features achieved by special materials or material structures}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- G02C 2202/24: Myopia progression prevention
- G02C: SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES (trial frames for testing the eyes A61B3/04; goggles or eyeshields not having the same features as spectacles A61F9/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS

## Abstract

A contact lens product includes a contact lens and a buffer solution. The contact lens is immersed in the buffer solution, and the buffer solution includes a cycloplegic agent.

## Claims

### Claim 1

A contact lens product, comprising:
a contact lens; and
a buffer solution, wherein the contact lens is immersed in the buffer solution, and the buffer solution comprises a cycloplegic agent;
wherein a weight percentage concentration of the cycloplegic agent in the buffer solution is ConA, a visible light absorption rate of the contact lens is Avi, a blue light absorption rate of the contact lens is Abl, an ultraviolet light absorption rate of the contact lens is Auv, and the following conditions are satisfied:
0%<ConA≤1%;
0%<Avi≤80%;
0%<Abl<100%; and
0%<Auv<100%.

### Claim 2 (depends on 1)

The contact lens product of claim 1, wherein a composition for manufacturing the contact lens comprises at least one visible light absorbing agent.

### Claim 3 (depends on 2)

The contact lens product of claim 2, wherein the visible light absorption rate of the contact lens is Avi, and the following condition is satisfied:
5%≤Avi≤70%.

### Claim 4 (depends on 2)

The contact lens product of claim 2, wherein the visible light absorbing agent is 1,4-bis[4-(2-methacryloxyethyl)phenylamino]anthraquinone or 1,4-bis[(2-methacryloxyethyl)amino]-9,10-anthraquinone.

### Claim 5 (depends on 1)

The contact lens product of claim 1, wherein a composition for manufacturing the contact lens comprises at least one short-wavelength light absorbing agent.

### Claim 6 (depends on 5)

The contact lens product of claim 5, wherein the blue light absorption rate of the contact lens is Abl, and the following condition is satisfied:
10%≤Abl≤80%.

### Claim 7 (depends on 5)

The contact lens product of claim 5, wherein the short-wavelength light absorbing agent is 4-(phenyldiazenyl) phenyl methacrylate or reactive yellow 15.

### Claim 8 (depends on 5)

The contact lens product of claim 5, wherein the ultraviolet light absorption rate of the contact lens is Auv, and the following condition is satisfied:
40%≤Auv<100%.

### Claim 9 (depends on 5)

The contact lens product of claim 5, wherein the short-wavelength light absorbing agent is 2-(2′-hydroxy-5′-methacryloxyethylphenyl)-2H-benzotriazole, 2-(4-benzoyl-3-hydroxyphenoxy)ethyl acrylate, 3-(3-(tert-butyl)-4-hydroxy-5-(5-methoxy-2H-benzo[d][1,2,3]triazol-2-yl)phenoxy) propyl methacrylate, 1,3-bis(4-benzoyl-3-hydroxyphenoxy)-2-propyl methacrylate, 1,3-bis(4-benzoyl-3-hydroxyphenoxy)-2-propanyl acrylate or N-(4-hydroxy-3-(5-methoxy-2H-benzo[d][1,2,3]triazol-2-yl)phenyl)methacrylamide.

### Claim 10 (depends on 1)

The contact lens product of claim 1, wherein the contact lens is made of a silicone hydrogel.

### Claim 11 (depends on 10)

The contact lens product of claim 10, wherein a composition for manufacturing the silicone hydrogel comprises at least two monomers, the monomer is 2-hydroxyethyl methacrylate, 3-methacryloyloxypropyltris(trimethylsilyloxy)silane, N-vinyl-2-pyrrolidinone, N,N-dimethyl acrylamide, methacrylic acid, methyl methacrylate, 3-(3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane or (3-acryloxy-2-hydroxypropoxypropyl)terminated polydimethylsiloxane.

### Claim 12 (depends on 1)

The contact lens product of claim 1, wherein the contact lens is made of a hydrogel.

### Claim 13 (depends on 12)

The contact lens product of claim 12, wherein a composition for manufacturing the hydrogel comprises at least two monomers, the monomer is 2-hydroxyethyl methacrylate, methacrylic acid, glycerol monomethacrylate or N-vinyl-2-pyrrolidinone.

### Claim 14 (depends on 1)

The contact lens product of claim 1, wherein the contact lens comprises:
a central region; and
at least one annular region surrounding the central region, wherein a diopter of the annular region is different from a diopter of the central region.

### Claim 15 (depends on 14)

The contact lens product of claim 14, wherein the annular region is a first annular region, the diopter of the central region of the contact lens is PowC, a maximum diopter of the first annular region of the contact lens is PowP1, and the following condition is satisfied:
|PowC−PowP1|≤12D.

### Claim 16 (depends on 14)

The contact lens product of claim 14, wherein a diameter of the central region of the contact lens is DiC, and the following condition is satisfied:
4 mm≤DiC≤10 mm.

### Claim 17 (depends on 14)

The contact lens product of claim 14, wherein the annular region is a first annular region, an outer diameter of the first annular region of the contact lens is DiP1, and the following condition is satisfied:
6 mm≤DiP1≤17 mm.

### Claim 18 (depends on 14)

The contact lens product of claim 14, wherein the annular region is a first annular region, a diameter of the central region of the contact lens is DiC, an outer diameter of the first annular region of the contact lens is DiP1, and the following condition is satisfied:
0.15≤DiC/DiP1<1.

### Claim 19 (depends on 14)

The contact lens product of claim 14, wherein a number of the annular regions of the contact lens is two, the annular regions are a first annular region and a second annular region, the central region, the second annular region and the first annular region are sequentially connected from a center of the contact lens to a periphery of the contact lens, and at least one of the central region, the second annular region and the first annular region is aspheric.

### Claim 20 (depends on 19)

The contact lens product of claim 19, wherein a diameter of the central region of the contact lens is DiC, an outer diameter of the second annular region of the contact lens is DiP2, and the following condition is satisfied:
0.2≤DiC/DiP2<1.