# US 10,371,832 B1 · Theranostic imaging with CZT gamma cameras

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- Number: US 10,371,832 B1
- Document ID: US10371832B1
- Status: Granted
- Kind: B1
- Application number: 16/116,430
- Filed: 2018-08-29
- Granted: 2019-08-06
- Earliest claimed: 2018-08-29
- Assignees: Kromek Group, PLC
- Applicants: Kromek Group, PLC
- Inventors: James William Hugg; Ian Radley
- Web page: https://patentgrep.com/patent/US10371832B1

## CPC

- G01T 1/1648: {Ancillary equipment for scintillation cameras, e.g. reference markers, devices for removing motion artifacts, calibration devices (adapted for flow studies G01T1/1647)}
- G01T 1/2023: {Selection of materials}
- G01T 1/249: {specially adapted for use in SPECT or PET (SPECT imaging G01T1/1642; PET imaging G01T1/2985; detecting prohibited goods, e.g. weapons, explosives, hazardous substances, contraband or smuggled objects G01V5/20)}
- G01T: MEASUREMENT OF NUCLEAR OR X-RADIATION (radiation analysis of materials, mass spectrometry G01N23/00; tubes for determining the presence, intensity, density or energy of radiation or particles H01J47/00)

## Abstract

One embodiment provides a method for imaging photons, including: receiving a dataset associated with a plurality of photon events, the photon events corresponding to photons interacting with a photon imaging device, wherein the photon imaging device comprises a photon guide assembly and a detector array; the photon guide assembly comprising a plurality of photon guides positioned at an oblique angle with respect to the detector array; and producing an oblique planar projection image of the plurality of photon events by processing the dataset. Other aspects are described and claimed.

## Claims

### Claim 1

A method for imaging photons, comprising:
receiving a dataset associated with a plurality of photon events, the photon events corresponding to photons interacting with a photon imaging device and each of the photon events having an incident path, wherein the photon imaging device comprises a photon guide assembly and a detector array;
the photon guide assembly comprising a plurality of photon guides positioned at an oblique angle with respect to the detector array, wherein the photon guides positioned at an oblique angle create a longer incident path of a photon event compared to a length of an incident path of a perpendicularly incident photon event; and
producing an oblique planar projection image of the plurality of photon events by processing the dataset and assigning a position of each photon event to a point of incidence on the detector array, wherein the assigning is based upon a measured depth of interaction along the longer incident path.

### Claim 2 (depends on 1)

The method of claim 1, wherein the photon imaging device comprises a gamma camera.

### Claim 3 (depends on 1)

The method of claim 1, wherein the detector array comprises a scintillator with at least one of: an array of photodetectors and an array of pixelated solid-state detectors.

### Claim 4 (depends on 3)

The method of claim 3, wherein the detector array comprises the array of pixelated solid-state detectors; and
wherein the array of pixelated solid-state detectors comprises one of: cadmium-zinc-telluride (CdZnTe or CZT) crystals and cadmium-telluride (CdTe) crystals.

### Claim 5 (depends on 1)

The method of claim 1, wherein the photon guide assembly comprises a collimator with at least one of: parallel slant holes, multiple pinholes, slanted coded aperture, and focused holes.

### Claim 6 (depends on 1)

The method of claim 1, wherein the processing the dataset comprises applying pixel charge-sharing corrections.

### Claim 7 (depends on 1)

The method of claim 1, wherein the processing the dataset comprises measuring a depth of interaction for each of the photon events.

### Claim 8 (depends on 1)

The method of claim 1, wherein the processing the dataset comprises combining Compton scattering events.

### Claim 9 (depends on 1)

The method of claim 1, further comprising reconstructing an image selected from the group consisting of: a stereo image and a tomographic image, using a plurality of the oblique planar projection images.

### Claim 10 (depends on 1)

The method of claim 1, further comprising a camera selected from the group consisting of: an optical photon camera and an infrared camera.

### Claim 11

A photon imaging device, comprising:
a photon guide assembly;
a detector array;
the photon guide assembly comprising a plurality of photon guides positioned at an oblique angle with respect to the detector array, wherein the photon guides positioned at an oblique angle create a longer incident path of a photon event compared to a length of an incident path of a perpendicularly incident photon event; and
a processor; and
a memory device that stores instructions executable by the processor to:
receive a dataset associated with a plurality of photon events, the photon events corresponding to photons interacting with the photon imaging device and each of the photon events having an incident path; and
produce an oblique planar projection image of the plurality of photon events by processing the dataset and assigning a position of each photon event to a point of incidence on the detector array, wherein the assigning is based upon a measured depth of interaction along the longer incident path.

### Claim 12 (depends on 11)

The device of claim 11, wherein the photon imaging device comprises a gamma camera.

### Claim 13 (depends on 11)

The device of claim 11, wherein the detector array comprises a scintillator with at least one of: an array of photodetectors and an array of pixelated solid-state detectors.

### Claim 14 (depends on 13)

The device of claim 13, wherein the detector array comprises the array of pixelated solid-state detectors; and
wherein the array of pixelated solid-state detectors comprises one of: cadmium-zinc-telluride (CdZnTe or CZT) crystals and cadmium-telluride (CdTe) crystals.

### Claim 15 (depends on 11)

The device of claim 11, wherein the photon guide assembly comprises a collimator with at least one of: parallel slant holes, multiple pinholes, slanted coded aperture, and focused holes.

### Claim 16 (depends on 11)

The device of claim 11, wherein the processing the dataset comprises applying pixel charge-sharing corrections.

### Claim 17 (depends on 11)

The device of claim 11, wherein the processing the dataset comprises measuring a depth of interaction for each of the photon events.

### Claim 18 (depends on 11)

The device of claim 11, wherein the processing the dataset comprises combining Compton scattering events.

### Claim 19 (depends on 11)

The device of claim 11, further comprising reconstructing an image selected from the group consisting of: a stereo image and a tomographic image, using a plurality of the oblique planar projection images.

### Claim 20

A product, comprising:
a storage device that stores code, the code being executable by a processor and comprising:
code that receives a dataset associated with a plurality of photon events, the photon events corresponding to photons interacting with a photon imaging device and each of the photon events having an incident path, wherein the photon imaging device comprises a photon guide assembly and a detector array;
the photon guide assembly comprising a plurality of photon guides positioned at an oblique angle with respect to the detector array, wherein the photon guides positioned at an oblique angle create a longer incident path of a photon event compared to a length of an incident path of a perpendicularly incident photon event; and
code that produces an oblique planar projection image of the plurality of photon events by processing the dataset and assigning a position of each photon event to a point of incidence on the detector array, wherein the assigning is based upon a measured depth of interaction along the longer incident path.
