# US 10,371,780 B2 · System and method for post-exposure dosimetry using electron paramagnetic resonance spectroscopy of teeth

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- Number: US 10,371,780 B2
- Document ID: US10371780B2
- Status: Granted
- Kind: B2
- Application number: 15/187,389
- Filed: 2016-06-20
- Published: 2016-12-22
- Granted: 2019-08-06
- Earliest claimed: 2015-06-19
- Assignees: Trustees of Dartmouth College
- Applicants: The Trustees of Dartmouth College
- Inventors: Sergey V. Petryakov; Wilson A. Schreiber; Harold M. Swartz; Benjamin B. Williams
- Web page: https://patentgrep.com/patent/US10371780B2

## CPC

- G01R 33/60: using electron paramagnetic resonance (G01R33/24, G01R33/62 take precedence)
- A61B 5/4547: {Evaluating teeth}
- G01R 33/341: comprising surface coils
- G01R 33/3628: {Tuning/matching of the transmit/receive coil}
- G01R 33/34007: {Manufacture of RF coils, e.g. using printed circuit board technology; additional hardware for providing mechanical support to the RF coil assembly or to part thereof, e.g. a support for moving the coil assembly relative to the remainder of the MR system}
- G01R 33/3642: {Mutual coupling or decoupling of multiple coils, e.g. decoupling of a receive coil from a transmission coil, or intentional coupling of RF coils, e.g. for RF magnetic field amplification}
- G01R 33/3685: {Means for reducing sheath currents, e.g. RF traps, baluns}
- G01R 33/3802: {Manufacture or installation of magnet assemblies; Additional hardware for transportation or installation of the magnet assembly or for providing mechanical support to components of the magnet assembly}
- G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of teeth. When operating in vivo, radiation induced spectra are obtained from intact teeth placed within a magnetic field and with a resonator having a loop and two capacitors formed in metal layers on a printed circuit substrate and located near teeth. The resonator is magnetically coupled to an RF measuring system. The spectra are used to determine radiation dose of a subject. The characteristics of the method and the apparatus make it feasible to utilize the system to measure radiation dose using previously untrained operators working in the field under emergency conditions.

## Claims

### Claim 1

Apparatus for performing electron paramagnetic resonance (EPR) spectrometry in teeth in vivo comprising:
a magnet having pole plates and gap sufficiently large to permit positioning a subject's head with at least one unextracted tooth of a subject within a uniform magnetic field zone provided by the magnet;
a device for positioning at least one resonator near the at least one unextracted tooth of the in-vivo subject;
a coupler configured to AC-couple the resonator to a radio frequency measuring device adapted to determining an EPR spectrum;
a processing system for computing a radiation dose based upon the EPR spectrum.

### Claim 2 (depends on 1)

The apparatus of claim 1, wherein the coupler magnetically couples to the resonator.

### Claim 3 (depends on 2)

The apparatus of claim 2, wherein the resonator comprises a loop and two capacitors, the loop and two capacitors formed in metal layers on a flexible printed-circuit substrate.

### Claim 4 (depends on 3)

The apparatus of claim 3, wherein the magnet is adapted to be positioned at a first angle and at a second angle with respect to the subject's head, wherein the processing system is configured to obtain first EPR spectra with the magnet at the first angle and second EPR spectra with the magnet at the second angle, and to use both the first and second EPR spectra in computing the radiation dose.

### Claim 5 (depends on 4)

The apparatus of claim 4, wherein the first angle and the second angle is determined by firmware of the processing system within a range of at least five degrees in either directions from an initial alignment of the head with respect to the magnet.

### Claim 6 (depends on 4)

The apparatus of claim 4, wherein the magnet is adapted to be positioned such that a difference between an initial alignment of the magnet with respect to the head and the first and second angles is between three and five degrees, and a difference between the first and second angles is between three and ten degrees.

### Claim 7 (depends on 4)

The apparatus of claim 4, wherein the magnet is adapted to be positioned at a third angle with respect to the subject's head, wherein the processing system is configured to obtain third EPR spectra with the magnet at the third angle, and to use the first, second, and third EPR spectra in computing the radiation dose.

### Claim 8 (depends on 7)

The apparatus of claim 7, wherein a difference between the first and second angle is approximately five degrees and a difference between the first and third angle is approximately ten degrees.

### Claim 9 (depends on 4)

The apparatus of claim 4, wherein the radio frequency measuring device comprises a quadrature multiple harmonic homodyne detector responsive to at least second and third harmonics.

### Claim 10 (depends on 8)

The apparatus of claim 8, wherein the radio frequency measuring device operates in L-band near 1.15 GHz.

### Claim 11 (depends on 4)

The apparatus of claim 4, wherein multiple EPR scans and collections of scans are acquired for a given subject and at a particular angle(s) of the magnet relative to the subject's head until further data acquisition is systematically determined to not significantly improve a precision of the dose measurement.

### Claim 12

A method for estimating dose in subjects to be triaged according to radiation dose comprising:
placing a resonator on an unextracted tooth of a subject, the resonator being magnetically coupled to a coupler attached to a radio frequency measuring device, the resonator comprising a loop and two capacitors, the resonator comprising a loop and two capacitors formed in metal layers on a flexible printed-circuit substrate;
applying a magnetic field to the unextracted tooth of the subject by positioning a head of the subject containing the unextracted tooth between poles of a magnet;
measuring at least one EPR spectrum of the unextracted tooth of the subject in the magnetic field by applying signals from a radio frequency source and using the radio frequency measuring device to determine responses of the unextracted tooth to the signals, the EPR spectrum being determined by sweeping either a frequency of the signals from the radio frequency source or a strength of the magnetic field; and
using a processing system to estimate whole-body radiation dose of the subject from the measured EPR spectra,
wherein the a magnet adapted to be positioned at least a first angle and at a second angle with respect to the subject's unextracted tooth, wherein the step of measuring at least one EPR spectra comprises measuring first EPR spectra with the magnet at the first angle and measuring second EPR spectra with the magnet at the second angle, and wherein estimating whole body radiation dose is performed by using both the first and second EPR spectra in computing the radiation dose.

### Claim 13 (depends on 12)

The method of claim 12, wherein the magnet is adapted to be positioned at a third angle with respect to the subject's unextracted tooth, wherein the step of measuring at least one EPR spectra includes obtain third EPR spectra with the magnet at the third angle, and the step of estimating whole body radiation dose uses the first, second, and third EPR spectra in computing the radiation dose.

### Claim 14 (depends on 13)

The method of claim 13, wherein the first and second angles are within a range of plus and minus five degrees from an initial alignment of magnet to the subject's unextracted tooth.

### Claim 15 (depends on 13)

The method of claim 13, wherein the step of measuring at least one EPR spectra comprises using a homodyne detector responsive to at least second and third harmonics.

### Claim 16

Apparatus for performing electron paramagnetic resonance (EPR) spectrometry in teeth in vivo comprising:
a magnet having sufficient space between poles for a subject's head to be positioned between the poles;
at least one resonator having a loop and two capacitors formed in metal layers on a printed circuit substrate and adapted for placement adjacent to at least one tooth of the subject;
a radio frequency measuring device adapted for determining at least one EPR spectrum;
a processing system for computing a radiation dose based upon the EPR spectrum, and;
an apparatus for outputting the radiation dose;
the at least one resonator coupled inductively to a loop antenna the loop antenna coupled through:
a first section of high-impedance coaxial cable of length approximately one-quarter wavelength having, at a first end, a center conductor of the first section of high impedance coaxial cable coupled to the loop antenna, and at a second end the center conductor of the first section of high-impedance coaxial cable coupled to an adjustment capacitor;
a second section of high-impedance coaxial cable of length approximately three-quarter wavelength having, at a first end, a center conductor of the second section of the high impedance coaxial coupled to the loop antenna, and at a second end the center conductor of the second section of high-impedance coaxial cable coupled to the adjustment capacitor;
a third section of high-impedance coaxial cable of length approximately three-quarter wavelength having, at a first end, a center conductor of the third section of high impedance coaxial cable coupled to the adjustment capacitor, and at a second end the center conductor of the third section of high-impedance coaxial cable is coupled to a center conductor of a coaxial transmission line coupled to the radio frequency measuring device.

### Claim 17 (depends on 12)

The method of claim 12 wherein the radio frequency measuring device is adapted to use multiple harmonic quadrature homodyne detection with reflection compensation responsive to at least the second and third harmonics of a frequency of the signals from the radio frequency stimulus device.