# US 10,371,779 B2 · Apparatus and method for magnetic resonance imaging with high spatial temporal resolutions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,371,779 B2 - Document ID: US10371779B2 - Status: Granted - Kind: B2 - Application number: 14/889,135 - Filed: 2010-03-09 - Published: 2016-06-16 - Granted: 2019-08-06 - Earliest claimed: 2009-03-09 - Assignees: The Johns Hopkins University - Applicants: Daniel Alfredo Herzka; John Andrew Derbyshire - Inventors: Daniel Alfredo Herzka; John Andrew Derbyshire - Web page: https://patentgrep.com/patent/US10371779B2 ## CPC - G01R 33/563: of moving material, e.g. flow contrast angiography - A61B 5/0036: {including treatment, e.g., using an implantable medical device, ablating, ventilating} - A61B 5/0205: Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61B 5/318: Heart-related electrical modalities, e.g. electrocardiography [ECG] - A61B 5/7207: {of noise induced by motion artifacts} - A61B 5/7257: {using Fourier transforms} - A61B 5/7285: {for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal} - A61B 18/20: using laser - G01R 33/36: Electrical details, e.g. matching or coupling of the coil to the receiver - G01R 33/385: using gradient magnetic field coils - G01R 33/4808: {Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]} - G01R 33/4824: {using a non-Cartesian trajectory} - G01R 33/56308: {Characterization of motion or flow; Dynamic imaging} - G01R 33/56325: {Cine imaging} - G01R 33/5676: {Gating or triggering based on an MR signal, e.g. involving one or more navigator echoes for motion monitoring and correction} - A61B 5/08: Measuring devices for evaluating the respiratory organs - A61B 5/1102: {Ballistocardiography} - A61B 5/113: occurring during breathing - A61B 2018/00577: {Ablation} - A61B 2018/00994: {combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound} - A61B 2576/00: Medical imaging apparatus involving image processing or analysis (A61B1/00009, A61B6/52 and A61B8/52 take precedence) - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A magnetic resonance imaging (MRI) system, comprising a magnetic resonance imaging scanner. The MR scanner comprises a main magnet providing a substantially uniform main magnetic field B0 for a subject under observation, the subject represented by a spatial distribution of magnetizations; a radio frequency (RF) coil system configured to irradiate a plurality of radio frequency (RF) pulses into a region of interest of the subject and to detect a plurality of RF response signals emitted from the region of interest; a gradient coil system configured to provide a perturbation of the main magnetic field B0 using a gradient pulse sequence that causes the RF response signals to encode the spatial distribution of magnetizations in a Fourier domain on a plurality of read-out paths; and a controller in communication with the RF coil system and the gradient coil system to synchronously provide the RF coil system with the plurality of RF pulses and the gradient coil system with the gradient pulse sequence. The gradient pulse sequence comprises a navigator pulse that causes one of the plurality of RF response signals to encode the spatial distribution of magnetizations in the Fourier domain on a pre-determined navigator path that represents a fixed projection of the region of interest of the subject, the pre-determined navigator path is suitable to be in a direction different from directions of the read-out paths, and the fixed projection of the subject is capable of tracking a motion of the subject. ## Claims ### Claim 1 A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner comprising: a main magnet providing a substantially uniform main magnetic field B0 for a subject under observation, said subject represented by a spatial distribution of magnetizations; a radio frequency (RF) coil system configured to irradiate a plurality of radio frequency (RF) pulses into a region of interest of said subject and to detect a plurality of RF response signals emitted from said region of interest; a gradient coil system configured to provide a perturbation of the main magnetic field B0 using a gradient pulse sequence that causes said RF response signals to encode said spatial distribution of magnetizations in a Fourier domain on a plurality of read-out paths; and a controller in communication with said RF coil system and said gradient coil system to synchronously provide said RF coil system with said plurality of RF pulses and said gradient coil system with said gradient pulse sequence, wherein said gradient pulse sequence comprises a navigator pulse that causes one of said plurality of RF response signals to encode said spatial distribution of magnetizations in said Fourier domain on a pre-determined navigator path that corresponds to a fixed projection of said region of interest of said subject, said pre-determined navigator path is suitable to be in a direction different from directions of said read-out paths, and said fixed projection of said subject is capable of tracking a motion of said subject. ### Claim 2 (depends on 1) The MRI system of claim 1, further comprising, a reconstructor to reconstruct a plurality of images representing said region of interest during said motion by combining said plurality of RF response signals. ### Claim 3 (depends on 2) The MRI system of claim 2, wherein at least one of said controller or said reconstructor is computer comprising a processor and a memory. ### Claim 4 (depends on 1) The MRI system of claim 1, further comprising: a monitoring device. ### Claim 5 (depends on 4) The MRI system of claim 4, wherein said monitoring device is at least one of a electrocardiogram (ECG) device or a respiration gating device. ### Claim 6 (depends on 1) The MRI system of claim 1, further comprising: a intervention device to provide treatment to said region of interest. ### Claim 7 (depends on 1) The MRI system of claim 1, wherein said intervention device is one of a RF ablator, a ultrasound applicator, a laser ablator, a laparoscopic device, or variants thereof. ### Claim 8 (depends on 1) The MRI system of claim 1, wherein said motion is one of a cardiac motion, a respiratory motion, or variations thereof.