# US 10,371,700 B2 · In-vitro diagnostic

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- Number: US 10,371,700 B2
- Document ID: US10371700B2
- Status: Granted
- Kind: B2
- Application number: 15/611,077
- Filed: 2017-06-01
- Published: 2017-12-07
- Granted: 2019-08-06
- Earliest claimed: 2016-06-02
- Assignees: Canon Medical Systems Corporation
- Applicants: Canon Medical Systems Corporation
- Inventors: Asuka Hirano; Shoichi Kanayama; Ichiro Tono
- Web page: https://patentgrep.com/patent/US10371700B2

## CPC

- G01N 33/54366: {Apparatus specially adapted for solid-phase testing}
- G01N 2405/00: Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

An in-vitro diagnostic includes a housing, a storage, and a blocking agent. The housing houses a liquid including a test substance included in a sample extracted from a subject. The storage stores a substance that specifically reacts with the test substance. The blocking agent is placed to separate the container and the storage.

## Claims

### Claim 1

An in-vitro diagnostic comprising:
a housing for a liquid comprising a test substance contained in a sample extracted from a subject;
an optical waveguide as a support;
a substance layer, on the optical waveguide, that stores a substance that specifically reacts with the test substance and a first blocking agent that supports the substance, wherein the substance is bound to a surface of the optical waveguide; and
a dry film comprising a soluble coating agent and a second blocking agent separating the housing and the substance layer, wherein the dry film covers a surface of the substance layer, wherein the dry film does not contain a substance that specifically reacts with the test substance, and wherein the second blocking agent is different from the first blocking agent.

### Claim 2 (depends on 1)

The in-vitro diagnostic according to claim 1, wherein the second blocking agent is dispersed into a soluble coating agent included in the dry film.

### Claim 3 (depends on 1)

The in-vitro diagnostic according to claim 1, wherein the second blocking agent is covered by a lipid film and is dispersed into a soluble coating agent included in the dry film.

### Claim 4 (depends on 1)

The in-vitro diagnostic according to claim 1, wherein the second blocking agent is covered by a lipid film and is attached on an upper surface of the dry film.

### Claim 5 (depends on 1)

The in-vitro diagnostic according to claim 1, wherein the second blocking agent is selected in accordance with a measurement item.