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US 10,371,642 B2Granted
Raman topography system and methods of imaging
OwnerCristina Zavaleta, Michael J. Mandella +1inventors
InventorsCristina Zavaleta, Michael J. Mandella, Zhen Qiu
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Abstract
The present disclosure describes a Raman topography system, which includes a container with at least one Raman probe positioned within. Also described are methods of imaging which include the Raman topography system.
Claims24
A method of imaging a sample, comprising:
- a) introducing a sample into a container of a Raman topography system, the system comprising:
- a container;
- at least one Raman probe positioned within the container, wherein the Raman probe includes:
- a Raman detection system, wherein the Raman detection system is configured to illuminate an area of a subject or a sample with a light source and to receive Raman scattered light energy from the area;
- a proximity sensor system configured to measure a distance from the Raman probe to the area;
- b) positioning the Raman probe at a target distance from a first area of the sample, wherein the positioning at the target distance is determined using a proximity sensor system configured to measure the distance from the Raman probe to the area;
- c) exposing the first area of the sample to a light beam from the Raman detection system, wherein the light beam is scattered by a Raman agent associated with the first area, wherein the light beam that is scattered is referred to as a Raman scattered light energy;
- d) detecting the Raman scattered light using a Raman imaging device;
- acquiring the Raman scattered light energy from the first area and each of the plurality of areas;
- and
- forming a topological map of the surface of the sample from the acquired Raman scattered light energy from the first area and each of the plurality of areas.
8 more elements
A method of imaging a sample, comprising:
- a) introducing a sample into a container of a Raman topography system, the system comprising:
- a container;
- at least one Raman probe positioned within the container, wherein the Raman probe includes:
- a Raman detection system, wherein the Raman detection system is configured to illuminate an area of a subject or a sample with a light source and to receive Raman scattered light energy from the area;
- a proximity sensor system configured to measure a distance from the Raman probe to the area;
- b) positioning the sample relative to the Raman probe at a distance from a first area of the sample, wherein the distance is determined using the proximity sensor system;
- c) exposing the first area of the sample to a light beam from the Raman detection system, wherein the light beam is scattered by a Raman agent associated with the first area, wherein the light beam that is scattered is referred to as a Raman scattered light energy;
- d) detecting the Raman scattered light using a Raman imaging device;
- and
- e) generating normalized Raman data from the Raman scattered light based on the distance measured using the proximity sensor system.
7 more elements
Dependencies are inferred from the claim text.