Prophylaxis of colorectal and gastrointestinal cancer
AssigneesLes Laboratoires Servier, Institut National De La Sante Et De La Recherche Medicale (Inserm), Centre National de la Recherche Scientifique (CNRS)
InventorsLeila Houhou, Mathieu Petremann, Dominique Joubert, Frédéric Hollande
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Abstract
The present disclosure provides methods and compositions useful for preventing gastrointestinal and/or colorectal cancer in animals, including humans, having pre-cancerous adenomatous polyps. The present disclosure provides compositions comprising anti-PG antibodies suitable for use in the methods of the disclosure. The present disclosure also provides methods and compositions useful for monitoring the efficacy of anti-PG treatment in subjects with pre-cancerous polyps.
Claims8
A method of inhibiting the formation of a progastrin-dependent gastrointestinal cancer in a human subject, comprising administering to a human subject an amount of an anti-PG monoclonal antibody sufficient to provide a therapeutic benefit, wherein said monoclonal antibody is selected from the group consisting of:
- a monoclonal antibody comprising VH CDRs comprising amino acid sequences of VH CDR 1.8 (SEQ ID NO:37), VH CDR 2.8 (SEQ ID NO:41), VH CDR 3.8 (SEQ ID NO:45) and VL CDRs comprising amino acid sequences of VL CDR 1.8 (SEQ ID NO:49), VL CDR 2.8 (SEQ ID NO:52), and VL CDR 3.8 (SEQ ID NO:55);
- a monoclonal antibody comprising VH CDRs comprising amino acid sequences of VH CDR 1.13 (SEQ ID NO:38), VH CDR 2.13 (SEQ ID NO:42), VH CDR 3.13 (SEQ ID NO:46) and VL CDRs comprising amino acid sequences of VL CDR 1.13 (SEQ ID NO:50), VL CDR 2.13 (SEQ ID NO:53), and VL CDR 3.13 (SEQ ID NO:56),
- a monoclonal antibody produced by a hybridoma deposited on Oct. 6, 2010 with the Collection Nationale de Cultures de Microorganisms (CNCM) under reference I-4371;
- a monoclonal antibody produced by a hybridoma deposited on Oct. 6, 2010 with the Collection Nationale de Cultures de Microorganisms (CNCM) under reference I-4372;
- a monoclonal antibody produced by a hybridoma deposited on Oct. 6, 2010 with the Collection Nationale de Cultures de Microorganisms (CNCM) under reference I-4373;
- a monoclonal antibody produced by a hybridoma deposited on Oct. 6, 2010 with the Collection Nationale de Cultures de Microorganisms (CNCM) under reference I-4374;
- a monoclonal antibody produced by a hybridoma deposited on Oct. 6, 2010 with the Collection Nationale de Cultures de Microorganisms (CNCM) under reference I-4375;
- wherein the subject has a mutation in the APC gene associated with adenomatous polyposis;
- and
- wherein the subject has familial adenomatous polyposis.
Dependencies are inferred from the claim text.