Compounds and methods of treating infections

A method of treating or preventing a bacterial infection or colonisation in a subject comprising administering a therapeutically effective amount of a compound selected from the group consisting of:

• 2,2′-bis[(2-fluorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL022);
• 2,2′-bis[(3-fluorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL023);
• 2,2′-bis[(2-cyanophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL025);
• 2,2′-bis[(3-cyanophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL026);
• 2,2′-bis[(3-methoxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL029);
• 2,2′-bis {[3-(trifluoromethyl)phenyl]methylene}carbonimidic dihydrazide hydrochloride (NCL037);
• 2,2′-bis[(2-methylphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL039);
• 2,2′-bis[(3-methylphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL040);
• 2,2′-bis{1-[4-(trifluoromethyl)phenyl]ethylidene}carbonimidic dihydrazide hydrochloride (NCL061);
• 2-{[1-(4-trifluoromethyl)phenyl]ethylidene}carbonimidic dihydrazide hydrochloride (NCL073);
• 2-[(4-chlorophenyl)methylene]-2′-[(4-methylphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL076);
• 2-{[2-fluoro-4-(trifluoromethyl)phenyl]methylene}-2′-[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL078);
• 2-[(4-chlorophenyl)methylene]-2′-[(4-fluorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL079);
• 2-{1-[4-(trifluoromethyl)phenyl]ethylidene}-2′-[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL080);
• 2-[(2-fluoro-4-chlorophenyl)methylene]-2′-[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL084);
• 2-[(2-cyanophenyl)methylene]-2′-[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL085);
• 2-[(3-cyanophenyl)methylene]-2′-[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL086);
• 2-[(2-fluorophenyl)methylene]-2′-[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL088);
• 2-[1-(4-chlorophenyl)ethylidene]-2′-{1-[4-(trifluoromethyl)phenyl]ethylidene}carbonimidic dihydrazide hydrochloride (NCL089);
• N-benzoyl-1-benzoyl-2-[(2-chlorophenyl)methylene]hydrazinecarboximidamide hydrochloride (NCL090);
• 2,2′-bis(cyclohexylmethylene)carbonimidic dihydrazide hydrochloride (NCL094);
• 2,2′-bis(3-furanylmethylene)carbonimidic dihydrazide hydrochloride (NCL095);
• 2,2′-bis[(3,4,5-trihydroxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL097);
• 2,2′-bis[(3-carboxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL098);
• 2,2′-bis {[4-(1,1-dimethylethyl)phenyl]methylene}carbonimidic dihydrazide hydrochloride (NCL099);
• 2,2′-bis[(2,3-dihydroxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL101);
• 2,2′-bis[(2,4,5-trihydroxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL104);
• 2,2′-bis[(2,3,4-trihydroxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL105);
• 2,2′-bis[(4,5-dihydroxy-3-methoxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL106);
• 2,2′-bis[(3-hydroxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL108);
• 2,2′-bis[(3,4-dihydroxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL111);
• 2,2′-bis([1,1′-biphenyl]-4-ylmethylene)carbonimidic dihydrazide hydrochloride (NCL112);
• 2,2′-bis[(3,5-dichlorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL114);
• 2,2′-bis[(3,4-dimethoxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL115);
• 2,2′-bis([1,1′-biphenyl]-2-ylmethylene)carbonimidic dihydrazide hydrochloride (NCL116);
• 2,2′-bis[(2,5-fluorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL118);
• 2,2′-bis[(4-acetamidophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL119);
• 2,2′-bis[(4-propylphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL121);
• 2,2′-bis [(4-hydroxy-3-nitrophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL122);
• 2,2′-bis[(3,4-difluorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL123);
• 2,2′-bis[(2-hydroxy-1-naphthalenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL124);
• 2,2′-bis[(3-hydroxy-4-methoxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL125);
• 2,2′-bis[(3-ethynylphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL126);
• 2,2′-bis[(3-bromo-4,5-dimethoxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL130);
• 2,2′-bis[(3-bromophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL131);
• 2,2′-bis[(4-chloro-6-fluoro-2H-1-benzopyran-3-yl)methylene]carbonimidic dihydrazide hydrochloride (NCL132);
• 2,2′-bis[(4-bromo-2-furanyl)methylene]carbonimidic dihydrazide hydrochloride (NCL133);
• 2,2′-bis[(2-bromo-4, 5-dimethoxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL135);
• 2,2′-bis[(4-butylphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL136);
• 2,2′-bis[(2,6-dichlorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL137);
• 2,2′-bis(2,3-diphenyl-2-propenylidene)carbonimidic dihydrazide hydrochloride (NCL138);
• 2,2′-bis(3-quinolinylmethylene)carbonimidic dihydrazide hydrochloride (NCL139);
• 2,2′-bis{[4-(methylsulfanyl)phenyl]methylene) carbonimidic dihydrazide hydrochloride (NCL140);
• 2,2′-bis[(5-chlorobenzo[b]thien-3-yl)methylene]carbonimidic dihydrazide hydrochloride (NCL141);
• 2,2′-bis[(5-bromo-2-furanyl)methylene]carbonimidic dihydrazide hydrochloride (NCL144);
• 2,2′-bis[(5-chloro-2-furanyl)methylene]carbonimidic dihydrazide hydrochloride (NCL145);
• 2,2′-bis(1H-indol-5-ylmethylene)carbonimidic dihydrazide hydrochloride (NCL146);
• 2,2′-bis(2-quinoxalinylmethylene)carbonimidic dihydrazide hydrochloride (NCL147);
• 2,2′-bis {[4-(carboxypropenyl)phenyl]methylene}carbonimidic dihydrazide hydrochloride (NCL148);
• 2,2′-bis[3-(4-methoxylphenyl)-2-propenylidene]carbonimidic dihydrazide hydrochloride (NCL150);
• 2,2′-bis[(2-hydroxy-3-methylphenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL152);
• 2,2′-bis[1-(4-chlorophenyl)propylidene]carbonimidic dihydrazide hydrochloride (NCL153);
• 2,2′-bis[1-(4-chlorophenyl)pentylidene]carbonimidic dihydrazide hydrochloride (NCL154);
• 2,2′-bis[1-(4-chlorophenyl)butylidene]carbonimidic dihydrazide hydrochloride (NCL156);
• 2,2′-bis[(2-amino-4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride (NCL157);
• 2,2′-bis[1-(2-hydroxy-4-chlorophenyl)propylidene]carbonimidic dihydrazide hydrochloride (NCL158);
• 2,2′-bis[(2-hydroxy-4-chlorophenyl)(cyclopentyl)methylene]carbonimidic dihydrazide hydrochloride (NCL159);
• 2,2′-bis[1-(4-piperazinylphenyl)ethylidene]carbonimidic dihydrazide hydrochloride (NCL161);
• 2,2′-bis[1-(2-amino-4-chlorophenyl)ethylidene]carbonimidic dihydrazide hydrochloride (NCL164);
• 2,2′-bis(1-phenyl-2-aminoethylidene)carbonimidic dihydrazide trihydrochloride (NCL165);
• 2,2′-bis{[4-(trifluoromethylsulfanyl)phenyl]methylene}carbonimidic dihydrazide hydrochloride (NCL166);
• 2,2′-bis(phenylcarboxymethylene)carbonimidic dihydrazide hydrochloride (NCL167);
• 2,2′-bis {[2-(1-hydroxyethylamino)-4-chlorophenyl]methylene}carbonimidic dihydrazide hydrochloride (NCL168);
• 2,2′-bis[(2-amino-4-chlorophenyl)methylene]carbonimidic dihydrazide (NCL169);
• 2,2′-bis[(2-acetamido-4-chlorophenyl)methylene]carbonimidic dihydrazide (NCL170);
• 2,2′-bis{[4-(dimethylamino)-2-hydroxyphenyl]methylene}carbonimidic dihydrazide (NCL171);
• 2,2′-Bis[1-(2-pyridinyl)ethylidene]Carbonimidic dihydrazide hydrochloride (NCL172);
• 2,2′-bis[1-(4-chloro-2-hydroxyphenyl)ethylidene]carbonimidic dihydrazide hydrochloride (NCL173);
• 2,2′-bis(4-chloro-2-hydroxyphenylmethylene)carbonimidic dihydrazide hydrochloride (NCL174);
• 2,2′-Bis(2-aminopyridin-3-ylmethylene)Carbonimidic dihydrazide hydrochloride (NCL176);
• 2,2′-bis[1-(4-chlorophenyl)-2-hydroxyethylidene]carbonimidic dihydrazide hydrochloride (NCL177);
• (E)-2-(1-(4-chlorophenyl)pentylidene)hydrazine-1-carboximidamide hydrochloride (NCL188);
• (Z)-2-(1-(4-chlorophenyl)-2-hydrazinylethylidene)hydrazine-1-carboximidamide hydrochloride (NCL190);
• 2,2′-bis[1-(4-chloro-2-fluorophenyl)ethylidene]carbonimidic dihydrazide hydrochloride (NCL215);
• N′,2-bis((E)-4-chloro-2-fluorobenzylidene)hydrazine-1-carboximidhydrazide hydrochloride (NCL216);
• N′,2-bis((E)-1-(p-tolyl)ethylidene)hydrazine-1-carboximidhydrazide hydrochloride (NCL217);
• 2,2′-bis{1-[4-(t-butyl)phenyl]ethylidene}) carbonimidic dihydrazide hydrochloride (NCL219);
• 2-((E)-4-chlorobenzylidene)-1-((E)-N′-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-ethylhydrazine-1-carboxamide (NCL226);
• N-benzyl-2-((E)-4-chlorobenzylidene)-1-((E)-N′-((E)-4-chlorobenzylidene)carbamohydrazonoyl)hydrazine-1-carboxamide (NCL227);
• 2-((E)-4-chlorobenzylidene)-1-((E)-N′-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-hexylhydrazine-1-carboxamide (NCL228);
• and 2-((E)-4-chlorobenzylidene)-1-((E)-N′-((E)-4-chlorobenzylidene)carbamohydrazonoyl)-N-(furan-2-ylmethyl)hydrazine-1-carboxamide (NCL229).