# US 10,369,522 B2 · Electrochemical cell > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,522 B2 - Document ID: US10369522B2 - Status: Granted - Kind: B2 - Application number: 15/107,663 - Filed: 2014-12-23 - Published: 2016-11-10 - Granted: 2019-08-06 - Earliest claimed: 2013-12-23 - Assignees: UniversitäT Innsbruck; Medizinische Universität Innsbruck - Applicants: UniversitäT Innsbruck; Medizinische UniversitäT Innsbruck - Inventors: Markus Kofler; Julia Dumpfarth; Michael Grimm; Georg Grimm; Gulnara Fauland; Thomas Bechtold - Web page: https://patentgrep.com/patent/US10369522B2 ## CPC - B01D 61/427: {Electro-osmosis} - B01D 61/463: {comprising the membrane sequence AC or CA, where C is a cation exchange membrane} - B01D 61/464: {comprising the membrane sequence CC} - B01D 2313/30: Specific dilution or de-ionizing chambers - B01D 2313/345: Electrodes - B01D 2325/42: Ion-exchange membranes - G01N 27/283: {Means for supporting or introducing electrochemical probes} - G01N 27/403: Cells and electrode assemblies - B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract Electrochemical cell array for the treatment of a sample via electro-(end-)osmotic flow, comprising (i) an electrode chamber, comprising a cathodic compartment (CC) and an anodic compartment (AC), (ii) a cathode (C), being arranged in the cathodic compartment (CC), (iii) an anode (A), being arranged in the anodic compartment (AC), (iv) an intermediate cathodic compartment (C1) (v) an intermediate anodic compartment (A1) (iv) a first selective membrane (M1) being arranged between said cathodic compartment (CC) and said first intermediate cathodic compartment (C1) (v) a second selective membrane (M2) being arranged between said anodic compartment (AC) and said first intermediate anodic compartment (A1) (vi) a treatment compartment (T) for the sample being arranged between said intermediate cathodic compartment (C1) and said intermediate anodic compartment (A1), further comprising a first separator membrane (S1) between said treatment compartment (T) and said intermediate cathodic compartment (C1) and a second separator membrane (S2) arranged between said treatment compartment (T) and said intermediate anodic compartment (A1). ## Claims ### Claim 1 An electrochemical cell for the treatment of a sample via electro-(end-)osmotic flow, comprising: (i) an electrode chamber, (ii) a cathode, being arranged in a cathodic compartment of said electrode chamber, (iii) an anode, being arranged in an anodic compartment of said electrode chamber, (iv) an intermediate cathodic compartment, (v) an intermediate anodic compartment, (vi) a first selective membrane being arranged between said cathodic compartment and said first intermediate cathodic compartment, (vii) a second selective membrane being arranged between said anodic compartment and said first intermediate anodic compartment, and (viii) a treatment compartment for the sample being arranged between said intermediate cathodic compartment and said intermediate anodic compartment, further comprising a first separator membrane between said treatment compartment and said intermediate cathodic compartment and a second separator membrane arranged between said treatment compartment and said intermediate anodic compartment, wherein the first separator membrane and the second separator membrane are electro-(end-)osmotically active membranes, and wherein the first separator membrane and the second separator membrane comprise a gel. ### Claim 2 (depends on 1) The electrochemical cell according to claim 1, wherein the sample is a solid sample, and wherein the electrochemical cell further comprises: (ix) a holding device for the solid sample placed in said treatment compartment dividing the treatment compartment into a cathodic treatment compartment and an anodic treatment compartment, wherein the holding device is configured so that when it carries the solid sample and is placed in the treatment compartment said holding device divides the treatment compartment into two separated compartments, the cathodic treatment compartment and the anodic treatment compartment, with the solid sample being exposed to both the cathodic treatment compartment and the anodic treatment compartment, wherein the holding device is placed between the cathodic treatment compartment and the anodic treatment compartment so that migration within the electrochemical cell occurs through biological material placed in the holding device. ### Claim 3 (depends on 1) The electrochemical cell according to claim 1, wherein the first separator membrane and the second separator membrane are composed of identical material. ### Claim 4 (depends on 1) The electrochemical cell according to claim 1, wherein the first selective membrane and the second selective membrane are selected from the group consisting of semipermeable membranes, ion exchanger membranes, ion-exchange diaphragms, and combinations thereof. ### Claim 5 (depends on 1) A method of treating a sample via electro-(end-)osmotic flow using an electrochemical cell according to claim 1, comprising placing an electrolyte in each of the cathodic compartment, the intermediate cathodic compartment, the intermediate anodic compartment, the anodic compartment, and the treatment compartment, placing the sample in the treatment compartment, and applying an electric current to the cathode and anode. ### Claim 6 (depends on 2) A method for treating a solid sample via electro-(end-) osmotic flow using an electrochemical cell according to claim 2, comprising placing an electrolyte in each of the cathodic compartment, the intermediate cathodic compartment, the intermediate anodic compartment, the anodic compartment, the cathodic treatment compartment, and the anodic treatment compartment, placing a solid sample in the holding device which is placed in the treatment compartment, and applying an electric current to the cathode and anode. ### Claim 7 (depends on 5) The method according to claim 5, wherein the sample comprises a solid biological material. ### Claim 8 (depends on 7) The method according to claim 7, wherein the solid biological material comprises pericardium. ### Claim 9 (depends on 5) The method according to claim 5, wherein the sample comprises a liquid biological material. ### Claim 10 (depends on 9) The method according to claim 9, wherein the liquid biological material is selected from the group consisting of blood and plasma. ### Claim 11 (depends on 1) The electrochemical cell according to claim 1, wherein the gel is selected from the group consisting of agarose gel, pectin gel, and swollen cellulose. ### Claim 12 (depends on 5) The method according to claim 5, wherein the sample comprises a biological material. ### Claim 13 (depends on 6) The method according to claim 6, wherein the solid sample comprises a solid biological material.