# US 10,369,383 B2 · Time-resolved pre-treatment portal dosimetry systems, devices, and methods > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,383 B2 - Document ID: US10369383B2 - Status: Granted - Kind: B2 - Application number: 16/274,695 - Filed: 2019-02-13 - Published: 2019-06-13 - Granted: 2019-08-06 - Earliest claimed: 2013-11-07 - Assignees: Varian Medical Systems International AG - Applicants: Varian Medical Systems International AG - Inventors: Frans Verhaegen; Mark Podesta; Sebastiaan M. J. J. G. Nijsten; Lucas C. G. G. Persoon; Christof Baltes; Stefan G. Scheib - Web page: https://patentgrep.com/patent/US10369383B2 ## CPC - A61N 5/1071: {for verifying the dose delivered by the treatment plan} - A61N 5/1031: {using a specific method of dose optimization} - A61N 5/1047: {with movement of the radiation head during application of radiation, e.g. for intensity modulated arc therapy or IMAT} - A61N 5/1075: {for testing, calibrating, or quality assurance of the radiation treatment apparatus} - A61N 2005/1054: {using a portal imaging system} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Systems, devices, and methods for pre-treatment verification of radiation dose delivery in arc-based radiation therapy devices using a time-dependent gamma evaluation method. ## Claims ### Claim 1 A system for determining radiation dose delivery, comprising: an imaging device generating images of incident radiation dose; and a processing device operably connected to the imaging device and configured to generate a time sequence of generated images by resampling the generated images into predetermined time intervals, the processing device being further configured to evaluate radiation dose delivery by assessing an amount of change of a parameter over time based on a result of comparing the generated images and corresponding predicted images belonging to same time intervals in the sequence. ### Claim 2 (depends on 1) The system of claim 1, wherein the predetermined time intervals are time intervals between control points of a radiation treatment plan. ### Claim 3 (depends on 1) The system of claim 1, wherein the parameter is the amount of voxels. ### Claim 4 (depends on 3) The system of claim 3, wherein radiation delivery is assessed based on the amount of voxels that change over time exceeding unity. ### Claim 5 (depends on 1) The system of claim 1, wherein the imaging device is an electronic portal dose imaging device (EPID). ### Claim 6 (depends on 1) The system of claim 1, wherein the comparing includes using a time-dependent gamma evaluation method. ### Claim 7 (depends on 6) The system of claim 6, wherein the comparing includes using the time-dependent gamma evaluation method to calculate dose differences, spatial differences, and time differences between points in the generated images and corresponding points in the predicted images. ### Claim 8 (depends on 7) The system of claim 7, wherein the processing device is further configured to store the predicted images as a first data set mapped as a first 4D array including positional information and time information of the points in the predicted images and store the generated images as a second data set mapped as a second 4D array including positional information and time information of the points in the generated images, wherein the comparing includes comparing the first data set with the second data set using the time-dependent gamma evaluation method. ### Claim 9 A method for determining radiation dose delivery, comprising: generating images of incident radiation; generating a time sequence of generated images by resampling the generated images into predetermined time intervals; comparing the generated images with corresponding predicted images belonging to same time intervals in the sequence; and assessing an amount of change of a parameter over time based on the comparison. ### Claim 10 (depends on 9) The method of claim 9, wherein the predetermined time intervals are time intervals between control points of a radiation treatment plan. ### Claim 11 (depends on 9) The method of claim 9, wherein the parameter is the amount of voxels. ### Claim 12 (depends on 11) The method of claim 11, wherein radiation delivery is assessed based on the amount of voxels that change over time exceeding unity. ### Claim 13 (depends on 9) The method of claim 9, wherein the comparing includes using a time-dependent gamma evaluation method. ### Claim 14 (depends on 13) The method of claim 13, wherein the comparing includes using the time-dependent gamma evaluation method to calculate dose differences, spatial differences, and time differences between points in the generated images and corresponding points in the predicted images. ### Claim 15 (depends on 14) The method of claim 14, further comprising storing the predicted images as a first data set mapped as a first 4D array including positional information and time information of the points in the predicted images and storing the generated images as a second data set mapped as a second 4D array including positional information and time information of the points in the generated images, wherein the comparing includes comparing the first data set with the second data set using the time-dependent gamma evaluation method. ### Claim 16 A non-transitory computer-readable storage medium upon which is embodied a sequence of programmed instructions for determining radiation dose delivery in a radiation treatment system including a computer processing device which executes the sequence of programmed instructions embodied on the computer-readable storage medium to cause the computer processing device to perform the steps of: obtaining images of incident radiation dose; generating a time sequence of the obtained images by resampling the images into predetermined time intervals; comparing the obtained images with corresponding predicted images belonging to same time intervals in the sequence; and assessing an amount of change of a parameter over time based on the comparison. ### Claim 17 (depends on 16) The non-transitory computer-readable medium of claim 16, wherein the predetermined time intervals are time intervals between control points of a radiation treatment plan. ### Claim 18 (depends on 16) The non-transitory computer-readable storage medium of claim 16, wherein the parameter is the amount of voxels. ### Claim 19 (depends on 18) The non-transitory computer-readable storage medium of claim 18, wherein radiation delivery is assessed based on the amount of voxels that change over time exceeding unity. ### Claim 20 (depends on 16) The non-transitory computer-readable storage medium of claim 16, wherein the comparing includes using a time-dependent gamma evaluation method. ### Claim 21 (depends on 20) The non-transitory computer-readable storage medium of claim 20, wherein the comparing includes using the time-dependent gamma evaluation method to calculate dose differences, spatial differences, and time differences between points in the obtained images and corresponding points in the predicted images. ### Claim 22 (depends on 21) The non-transitory computer-readable storage medium of claim 21, further comprising storing the predicted images as a first data set mapped as a first 4D array including positional information and time information of the points in the predicted images and storing the obtained images as a second data set mapped as a second 4D array including positional information and time information of the points in the obtained images, wherein the comparing includes comparing the first data set with the second data set using the time-dependent gamma evaluation method.