# US 10,369,366 B2 · Implantable electrostimulator for improving blood flow > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,366 B2 - Document ID: US10369366B2 - Status: Granted - Kind: B2 - Application number: 15/726,971 - Filed: 2017-10-06 - Published: 2018-02-01 - Granted: 2019-08-06 - Earliest claimed: 2015-06-10 - Assignees: Bluewind Medical Ltd. - Applicants: Bluewind Medical Ltd. - Inventors: Gur Oron; Yossi Gross; Bar Eytan; Eran Benjamin; Karin Aharonson-Raz - Web page: https://patentgrep.com/patent/US10369366B2 ## CPC - A61N 1/3606: {adapted for a particular treatment} - A61N 1/36135: {using physiological parameters} - A61N 1/37205: {Microstimulators, e.g. implantable through a cannula} - A61N 1/3756: {Casings with electrodes thereon, e.g. leadless stimulators} - A61N 1/3787: {from an external energy source} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Apparatus includes an implant and an introducer. The implant includes an injectable housing, an electrode disposed on an outer surface of the housing, and circuitry. The circuitry is configured to alternate between a first mode in which the circuitry drives the electrode to apply a first electrical current having a frequency of 1-100 Hz, and a second mode in which the implant applies a second electrical current having a frequency of 1-10 kHz. The introducer includes a tube that defines a lumen and is percutaneously-advanceable into tissue of the subject, the lumen being dimensioned to at least temporarily house the implant. The introducer is configured to deploy the implant from a distal end of the lumen by moving the implant and the distal end of the lumen relative to each other. Other embodiments are also described. ## Claims ### Claim 1 Apparatus for treating a subject who suffers from both peripheral artery occlusive disease and polyneuropathy, the apparatus comprising: an implant, comprising: an injectable housing, an electrode disposed on an outer surface of the housing, and circuitry, configured: (i) with a first mode in which the circuitry drives the electrode to apply a first electrical current having a frequency of 1-100 Hz, (ii) with a second mode in which the implant applies a second electrical current having a frequency of 1-10 kHz, and (iii) to alternate the implant between the first mode and the second mode; and an introducer: comprising a tube defining a lumen, the tube being percutaneously-advanceable into tissue of the subject, and the lumen dimensioned to at least temporarily house the implant, and configured to deploy the implant from a distal end of the lumen by moving the implant and the distal end of the lumen relative to each other. ### Claim 2 (depends on 1) The apparatus according to claim 1, wherein the implant further comprises a temperature sensor, configured to detect a temperature of the tissue, and wherein the circuitry is configured to drive the electrode to apply the first electrical current in response to the detected temperature being below a threshold temperature. ### Claim 3 (depends on 1) The apparatus according to claim 1, wherein the implant further comprises a pressure sensor, configured to detect a pressure within the tissue, and the circuitry is configured to drive the electrode to apply the first electrical current at least in part responsively to the detected pressure. ### Claim 4 (depends on 3) The apparatus according to claim 3, wherein the pressure comprises a pulse pressure, and the circuitry is configured to drive the electrode to apply the first electrical current at least in part responsively to the detected pulse pressure. ### Claim 5 (depends on 1) The apparatus according to claim 1, wherein the implant further comprises an oximeter, configured to detect an oxygen saturation within the tissue, and the circuitry is configured to drive the electrode to apply the first electrical current at least in part responsively to the detected oxygen saturation. ### Claim 6 (depends on 1) The apparatus according to claim 1, wherein the circuitry is configured to remain in the first mode for a first-mode duration of 1-30 minutes. ### Claim 7 (depends on 6) The apparatus according to claim 6, wherein the circuitry is configured to remain in the first mode for a first-mode duration of 2-20 minutes. ### Claim 8 (depends on 7) The apparatus according to claim 7, wherein the circuitry is configured to remain in the first mode for a first-mode duration of 5-15 minutes. ### Claim 9 (depends on 1) The apparatus according to claim 1, wherein the circuitry is configured to remain in the second mode for a second-mode duration of 1-30 minutes. ### Claim 10 (depends on 9) The apparatus according to claim 9, wherein the circuitry is configured to remain in the second mode for a second-mode duration of 2-20 minutes. ### Claim 11 (depends on 10) The apparatus according to claim 10, wherein the circuitry is configured to remain in the second mode for a second-mode duration of 5-15 minutes. ### Claim 12 (depends on 1) The apparatus according to claim 1, wherein the circuitry is configured to remain in the first mode for a first-mode duration, and to remain in the second mode for a second-mode duration that is the same as the first-mode duration. ### Claim 13 (depends on 1) The apparatus according to claim 1, wherein the circuitry is configured to remain in the first mode for a first-mode duration, and to remain in the second mode for a second-mode duration that is different from the first-mode duration.