# US 10,369,364 B2 · Devices and methods to use power spectrum or signal association for pain management > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,364 B2 - Document ID: US10369364B2 - Status: Granted - Kind: B2 - Application number: 16/138,381 - Filed: 2018-09-21 - Published: 2019-01-24 - Granted: 2019-08-06 - Earliest claimed: 2014-09-22 - Assignees: Boston Scientific Neuromodulation Corporation - Applicants: Boston Scientific Neuromodulation Corporation - Inventors: Michael A. Moffitt; Hemant Bokil - Web page: https://patentgrep.com/patent/US10369364B2 ## CPC - A61N 1/36071: {Pain} - A61B 5/37: Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG] - A61B 5/372: Analysis of electroencephalograms - A61B 5/374: Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves - A61N 1/36139: {with automatic adjustment} - A61B 5/7246: {using correlation, e.g. template matching or determination of similarity} - A61B 5/7257: {using Fourier transforms} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Methods and systems for electrical stimulation can include obtaining a biosignal of the patient; altering at least one stimulation parameter of an electrical stimulation system in response to the biosignal; and delivering an electrical stimulation current to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter. In some embodiments, a power spectrum is determined from the biosignal. In some embodiments, the biosignal is at least two different biosignals measured at the same or different locations on the patient and a coherence, correlation, or association between the two biosignal is determined. ## Claims ### Claim 1 An electrical stimulation system, comprising: an implantable control module configured and arranged for implantation in a body of a patient, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for electrical stimulation of patient tissue, wherein the implantable control module comprises a processor configured and arranged to perform the following actions: obtaining at least two different biosignals of the patient, determining a measure of association between the at least two different biosignals, altering at least one stimulation parameter of the electrical stimulation system in response to the measure of association between the at least two different biosignals, and directing delivery of electrical stimulation signals to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter. ### Claim 2 (depends on 1) The system of claim 1, wherein determining the measure of association comprises determining a measure of coherence between the at least two different biosignals. ### Claim 3 (depends on 1) The system of claim 1, wherein determining the measure of association comprises determining a measure of correlation between the at least two different biosignals. ### Claim 4 (depends on 1) The system of claim 1, wherein obtaining the at least two different biosignals of the patient comprises obtaining an electroencephalogram of a theta band for the patient and an electroencephalogram of a gamma band for the patient. ### Claim 5 (depends on 1) The system of claim 1, wherein obtaining the at least two different biosignals of the patient comprises obtaining a same type of biosignal at two different points in time. ### Claim 6 (depends on 1) The system of claim 1, wherein obtaining the at least two different biosignals of the patient comprises obtaining a same type of biosignal at two different locations on a body of the patient. ### Claim 7 (depends on 6) The system of claim 6, wherein directing delivery of the electrical stimulation signals comprises directing delivery of the electrical stimulation signals to a plurality of selected electrodes to produce stimulation to different stimulation sites. ### Claim 8 (depends on 1) The system of claim 1, wherein determining the measure of association comprises determining the measure of association between the at least two different biosignals to determine whether the measure of association is indicative of synchronous activity. ### Claim 9 (depends on 8) The system of claim 8, wherein directing delivery of the electrical stimulation signals comprises directing delivery of the electrical stimulation signals to a plurality of selected electrodes to produce stimulation to different stimulation sites to desynchronize the synchronous activity. ### Claim 10 (depends on 1) The system of claim 1, wherein determining the measure of association comprises determining the measure of association between the at least two different biosignals to determine whether the measure of association is indicative of pain. ### Claim 11 An electrical stimulation system, comprising: an implantable control module configured and arranged for implantation in a body of a patient and comprising an antenna and a processor coupled to the antenna, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for electrical stimulation of patient tissue; and an external programming unit configured and arranged to communicate with the processor of the implantable control module using the antenna and to adjust stimulation parameters for production of the electrical stimulation signals, wherein the external programming unit comprises a processor configured and arranged to perform the following actions: obtaining at least two different biosignals of the patient, determining a measure of association between the at least two different biosignals, and altering at least one stimulation parameter of the electrical stimulation system in response to the measure of association between the at least two different biosignals; wherein the processor of the implantable control module is configured to direct delivery of electrical stimulation signals to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter. ### Claim 12 (depends on 11) The system of claim 11, wherein determining the measure of association comprises determining a measure of coherence between the at least two different biosignals. ### Claim 13 (depends on 11) The system of claim 11, wherein determining the measure of association comprises determining a measure of correlation between the at least two different biosignals. ### Claim 14 (depends on 11) The system of claim 11, wherein obtaining the at least two different biosignals of the patient comprises obtaining an electroencephalogram of a theta band for the patient and an electroencephalogram of a gamma band for the patient. ### Claim 15 (depends on 11) The system of claim 11, wherein obtaining the at least two different biosignals of the patient comprises obtaining a same type of biosignal at two different points in time. ### Claim 16 (depends on 11) The system of claim 11, wherein obtaining the at least two different biosignals of the patient comprises obtaining a same type of biosignal at two different locations on a body of the patient. ### Claim 17 (depends on 16) The system of claim 16, wherein directing delivery of the electrical stimulation signals comprises directing delivery of the electrical stimulation signals to a plurality of selected electrodes to produce stimulation to different stimulation sites. ### Claim 18 (depends on 11) The system of claim 11, wherein determining the measure of association comprises determining the measure of association between the at least two different biosignals to determine whether the measure of association is indicative of synchronous activity. ### Claim 19 (depends on 18) The system of claim 18, wherein directing delivery of the electrical stimulation signals comprises directing delivery of the electrical stimulation signals to a plurality of selected electrodes to produce stimulation to different stimulation sites to desynchronize the synchronous activity. ### Claim 20 (depends on 11) The system of claim 11, wherein determining the measure of association comprises determining the measure of association between the at least two different biosignals to determine whether the measure of association is indicative of pain.