# US 10,369,329 B2 · Neurosurgical apparatus and method > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,329 B2 - Document ID: US10369329B2 - Status: Granted - Kind: B2 - Application number: 14/610,185 - Filed: 2015-01-30 - Published: 2015-07-30 - Granted: 2019-08-06 - Earliest claimed: 2014-01-30 - Assignees: Renishaw PLC - Applicants: Renishaw PLC - Inventors: Steven Streatfield Gill - Web page: https://patentgrep.com/patent/US10369329B2 ## CPC - A61M 25/0067: {characterised by the distal end, e.g. tips (A61M25/0054, A61M25/04 take precedence; balloon catheters A61M25/10)} - A61M 2210/0693: Brain, cerebrum - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A method for delivering fluid to the brain of a subject using an intraparenchymal catheter, the method comprising the step of inserting the catheter into the brain using a posterior to anterior approach and methods of treating neurodegenerative disorders using this delivery method, as well as methods for delivering fluid to an elongate structure of the brain using an intraparenchymal catheter, the method comprising the step of inserting a catheter into the brain along an insertion axis that is substantially aligned with a long axis of the elongate structure. ## Claims ### Claim 1 A method for delivering a fluid to a brain of a subject, the method comprising delivering the fluid to the brain by inserting at least one intraparenchymal catheter into a target volume of the brain using a posterior to anterior approach along an insertion axis that is substantially aligned with a long axis of the target volume, wherein the target volume is at least one of the putamen, globus pallidus and the head of the caudate nucleus, and the catheter is inserted along a trajectory through an occipitoparietal region, the trajectory substantially parallel to an anterior commissure-posterior commissure plane. ### Claim 2 (depends on 1) The method of claim 1, wherein the trajectory is aligned with the long axis of the target volume to within 30° or less. ### Claim 3 (depends on 1) The method of claim 1, further comprising inserting at least a second intraparenchymal catheter into the target volume of the brain using the posterior to anterior approach. ### Claim 4 (depends on 1) The method of claim 1, wherein the subject is under general anaesthetic and in a prone position. ### Claim 5 (depends on 1) The method of claim 1, further comprising inserting at least a second intraparenchymal catheter into the target volume of the brain using the posterior to anterior approach, wherein the catheters are inserted bilaterally into the target volume of the brain. ### Claim 6 A method for treating a neurodegenerative disorder, the method comprising delivering a fluid to a brain of a subject by inserting at least one intraparenchymal catheter into a target volume of the brain using a posterior to anterior approach along an insertion axis that is substantially aligned with a long axis of the target volume, wherein the target volume is at least one of the putamen, globus pallidus and the head of the caudate nucleus, and the catheter is inserted along a trajectory through an occiptoparietal region, the trajectory substantially parallel to an anterior commissure-posterior commissure plane. ### Claim 7 (depends on 6) The method of claim 6, wherein the neurodegenerative disorder is at least one of Multiple-System Atrophy, Progressive Supranuclear Palsy (PSP), Parkinson's Disease, Huntington's Disease, dystonia, tremor, Tourette's syndrome and lysosomal storage diseases. ### Claim 8 (depends on 6) The method of claim 6, wherein the trajectory is aligned with the long axis of the target volume to within 30° or less. ### Claim 9 (depends on 6) The method of claim 6, further comprising inserting at least a second intraparenchymal catheter into the target volume of the brain using the posterior to anterior approach. ### Claim 10 (depends on 6) The method of claim 6, wherein the subject is under general anaesthetic and in a prone position. ### Claim 11 (depends on 6) The method of claim 6, further comprising inserting at least a second intraparenchymal catheter into the target volume of the brain using the posterior to anterior approach, wherein the catheters are inserted bilaterally into the target volume of the brain. ### Claim 12 A method for delivering a fluid to an elongate structure of a brain of a subject, the method comprising delivering the fluid to the elongate structure by inserting at least one intraparenchymal catheter having a step into the brain using a posterior to anterior approach along an insertion axis that is substantially aligned with a long axis of the elongate structure, wherein the step is located within the elongate structure, the elongate structure is at least one of the putamen, globus pallidus and the head of the caudate nucleus, and the catheter is inserted along a trajectory through an occipitoparietal region, the trajectory substantially parallel to an anterior commissure-posterior commissure plane. ### Claim 13 (depends on 12) The method according to claim 12, wherein the insertion axis is aligned with the long axis of the elongate structure to within 30° or less. ### Claim 14 (depends on 12) The method of claim 12, wherein the subject is under general anaesthetic and in a prone position. ### Claim 15 (depends on 12) The method of claim 12, wherein the fluid includes at least one therapeutic agent selected from the group consisting of a chemotherapy drug, a neurotrophin, an enzyme, a growth factor, an antibody, an immunotoxin, small inhibitory RNA (siRNA), antisense oligonucleotides, viral vectors, drug releasing nanoparticles, and transgenes.