# US 10,369,301 B2 · Nebulizers and uses thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,301 B2 - Document ID: US10369301B2 - Status: Granted - Kind: B2 - Application number: 16/026,572 - Filed: 2018-07-03 - Published: 2018-11-01 - Granted: 2019-08-06 - Earliest claimed: 2014-10-13 - Assignees: Omega Life Science Ltd. - Applicants: Omega Life Science Ltd. - Inventors: Miron Hazani - Web page: https://patentgrep.com/patent/US10369301B2 ## CPC - A61M 11/02: operated by air {or other gas} pressure applied to the liquid {or other product} to be sprayed or atomised {(sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C)} - A61M 11/003: {by passing the aerosol trough sieves or filters} - A61M 11/005: {using ultrasonics (spraying or atomising liquids using ultrasonic vibrations in general B05B17/06)} - A61M 15/00: Inhalators {(drug delivery in endotracheal tubes A61M16/04)} - A61M 15/0001: {Details of inhalators; Constructional features thereof} - A61M 15/0021: {Mouthpieces therefor} - A61M 11/002: {by flow deviation causing inertial separation of transported particles} - A61M 2202/0468: non-physiological - A61M 2205/0272: Electro-active or magneto-active materials - A61M 2205/0288: Electro-rheological or magneto-rheological materials - A61M 2205/103: rotating - A61M 2205/12: with interchangeable cassettes forming partially or totally the fluid circuit - A61M 2205/123: with incorporated reservoirs - A61M 2205/3331: Pressure; Flow - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract The present disclosure generally relates to the field of nebulizers for aerosol generation and methods of using same for treating diseases and disorders. ## Claims ### Claim 1 A nebulizer comprising: a porous medium configured to produce aerosols, the porous medium having a first side and a second side, a liquid absorbing material configured to absorb a liquid, the liquid absorbing material having a first side and a second side, a wetting mechanism configured to press the liquid absorbing material against the porous medium, thereby to wet the porous medium with the liquid absorbed in the liquid absorbing material, an opening configured to deliver aerosols to a subject, and a gas channel configured to introduce a gas pressure gradient, such that the first side of the porous medium and the second side of the porous medium have different gas pressure levels, thereby producing the aerosol, wherein the wetting mechanism is attached to the first side of the liquid absorbing material, wherein the first side of the porous medium is facing the liquid absorbing material and the opening, and the second side of the porous medium is facing the gas channel. ### Claim 2 (depends on 1) The nebulizer of claim 1, wherein the liquid absorbing material is selected from a sponge, a tissue and foam. ### Claim 3 (depends on 1) The nebulizer of claim 1, wherein the liquid absorbing material is configured to act as an impactor for aerosols produced by the porous medium. ### Claim 4 (depends on 1) The nebulizer of claim 1, wherein the liquid absorbing material comprises at least one pharmaceutical composition. ### Claim 5 (depends on 1) The nebulizer of claim 1, further comprising a first container, configured to contain liquid to be delivered to the liquid absorbing material. ### Claim 6 (depends on 5) The nebulizer of claim 5, wherein the liquid comprises water. ### Claim 7 (depends on 1) The nebulizer of claim 1, wherein the wetting mechanism comprises a rod and a solid plate connected to the liquid absorbing material. ### Claim 8 (depends on 1) The nebulizer of claim 1, wherein introducing the gas pressure gradient comprises introducing pressurized air to the second side of the porous medium. ### Claim 9 (depends on 1) The nebulizer of claim 1, wherein introducing the gas pressure gradient comprises introducing vacuum or sub-atmospheric pressure to the first side of the porous medium. ### Claim 10 (depends on 8) The nebulizer of claim 8, wherein the gas channel is connected to a gas source. ### Claim 11 A nebulizer cartridge, comprising: a porous medium, and a liquid absorbing material, configured to be pressed against the porous medium thereby to wet the porous medium with the liquid absorbed in the liquid absorbing material, wherein the liquid absorbing material comprises a liquid absorbed therein, wherein the wetting mechanism comprises a rod and a solid plate connected to the liquid absorbing material. ### Claim 12 (depends on 11) The nebulizer cartridge of claim 11, wherein the liquid absorbing material comprises a sponge. ### Claim 13 (depends on 11) The nebulizer cartridge of claim 11, wherein the liquid is a pharmaceutical composition. ### Claim 14 (depends on 11) The nebulizer cartridge of claim 11, further comprising a container configured to contain liquid to be delivered to the liquid absorbing material. ### Claim 15 (depends on 11) The nebulizer cartridge of claim 11, configured to be inserted to a nebulizer main body. ### Claim 16 A nebulizer system comprising a housing; an opening in the housing configured to deliver aerosols to a subject; a cartridge comprising a porous medium having a first side and a second side, and a liquid absorbing material, configured to be pressed against the porous medium thereby to wet the porous medium with the liquid absorbed in the liquid absorbing material; a receptacle configured to receive the cartridge; and a gas channel configured to introduce gas pressure gradient, such that the first side of the porous medium and the second side of the porous medium have different gas pressure levels, thereby producing the aerosol, wherein the first side of the porous medium is configured to face the liquid absorbing material and the opening, and the second side of the porous medium is configured to face the gas channel when the cartridge is received within the receptacle. ### Claim 17 (depends on 16) The nebulizer system of claim 16, wherein the liquid absorbing material comprises a sponge, a tissue or foam. ### Claim 18 (depends on 16) The nebulizer of claim 16, wherein the liquid absorbing material comprises at least one pharmaceutical composition at least partially absorbed therein. ### Claim 19 (depends on 16) The nebulizer of claim 16, further comprising a first container, configured to contain liquids to be delivered to the liquid absorbing material. ### Claim 20 (depends on 16) The nebulizer system of claim 16, wherein introducing the gas pressure gradient is selected from introducing pressurized air to the second side of the porous medium and introducing vacuum or sub-atmospheric pressure to the first side of the porous medium.