# US 10,369,300 B2 · Aerosol generator for generating an inhalation aerosol > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,300 B2 - Document ID: US10369300B2 - Status: Granted - Kind: B2 - Application number: 14/772,413 - Filed: 2014-03-07 - Published: 2016-01-21 - Granted: 2019-08-06 - Earliest claimed: 2013-03-07 - Assignees: Medspray Xmems B.V. - Applicants: Medspray Xmems B.V. - Inventors: Wilhelmus Petrus Johannes De Kruijf; Wietze Nijdam; Jeroen Mathijn Wissink; Tom Vincent Huijgen - Web page: https://patentgrep.com/patent/US10369300B2 ## CPC - A61M 11/02: operated by air {or other gas} pressure applied to the liquid {or other product} to be sprayed or atomised {(sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C)} - A61M 11/003: {by passing the aerosol trough sieves or filters} - A61M 11/006: {operated by applying mechanical pressure to the liquid to be sprayed or atomised} - A61M 11/06: of the injector type - A61M 11/08: Pocket atomisers of the injector type {(aerosol cans A61M15/009)} - A61M 15/0005: {with means for agitating the medicament} - A61M 15/0021: {Mouthpieces therefor} - A61M 15/009: {using medicine packages with incorporated spraying means, e.g. aerosol cans (pocket atomiser of the injector type A61M11/08)} - A61M 2205/70: with testing or calibration facilities - A61M 2206/10: Flow characteristics - A61M 2206/16: Rotating swirling helical flow, e.g. by tangential inflows - A61M 2206/18: Coaxial flows, e.g. one flow within another - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract An aerosol generator for generating an inhalation aerosol from an inhalation liquid, includes an intake duct for guiding air to a mouth of a user, and a nozzle, arranged in the intake duct for injecting the inhalation liquid into the intake duct. The nozzle is arranged for generating a Rayleigh droplet train of the inhalation liquid propagating along a droplet train propagation path. The intake duct includes at least two first orifices having at least partly opposing discharging directions extending towards the droplet train propagation path. The at least two first orifices are configured for providing respective first air streams in at least partly opposing directions so as to interact in the droplet train propagation path. ## Claims ### Claim 1 An aerosol generator for generating an inhalation aerosol from an inhalation liquid, comprising: an intake duct having an outlet for guiding air to a mouth of a user and having an inlet allowing ambient air to be drawn in as the user inhales though the device; and a nozzle, arranged for generating a Rayleigh droplet train of droplets of said inhalation liquid and for injecting said droplet train into the intake duct along a droplet train propagation path, wherein the intake duct comprises at least two first orifices, communicating with said inlet, each of the first orifices having a discharging direction in which, during operation, a respective first air stream discharges from one of the at least two first orifices into said intake duct in a direction that crosses said droplet train propagation path; wherein the intake duct comprises at least one second orifice, in communication with said inlet, said second orifice having a discharge direction in which, during operation, a second air stream enters said intake duct substantially in a longitudinal direction to said outlet of said intake duct; and wherein the first orifices are arranged to release the respective first air streams in mutually crossing discharge directions, directed towards and into the droplet train propagation path, so as to interact with each other and with said droplets in said droplet train along said droplet train propagation path downstream of said nozzle. ### Claim 2 (depends on 1) The aerosol generator according to claim 1, wherein the at least two first orifices are configured for generating the first air streams at an angle in a range of 30 to 150 degrees in respect of the droplet train propagation path and having opposing, mutually facing directions, the first air streams propagating at said angle into the droplet train propagation path. ### Claim 3 (depends on 2) The aerosol generator according to claim 2, wherein said angle is substantially 90 degrees. ### Claim 4 (depends on 1) The aerosol generator according to claim 1, wherein the at least two first orifices are configured for generating the first air streams to mutually impinge in the droplet train propagation path, the first air streams propagating from the at least two first orifices at mutually impinging directions into the droplet train propagation path. ### Claim 5 (depends on 1) The aerosol generator according to claim 1, wherein the at least two first orifices are arranged along at least one circle around the droplet train propagation path and configured to generate the first air streams in pairwise opposing directions, the aerosol generator being configured to provide that the first air streams propagate in pairwise opposing directions into the droplet train propagation path. ### Claim 6 (depends on 1) The aerosol generator according to claim 1, wherein a ratio of a distance of an outlet of the at least two first orifices to the droplet train propagation path in respect of a diameter of the at least two first orifices is in a range of 3:1 to 30:1. ### Claim 7 (depends on 1) The aerosol generator according to claim 1, wherein the at least two first orifices are arranged for generating a homogenous turbulence in the droplet train propagation path having a length scale in a range of 1-50 μm. ### Claim 8 (depends on 1) The aerosol generator according to claim 1, wherein the nozzle is arranged for providing primary droplets in a range of 2-12 microns. ### Claim 9 (depends on 1) The aerosol generator according to claim 1, wherein a ratio of the magnitude of the second air stream from the at least one second orifice and the magnitude of the first air streams from the first orifices is at least 2 to 1. ### Claim 10 (depends on 1) The aerosol generator according to claim 1, wherein the nozzle comprises a plurality of at least five nozzle orifices for generating a plurality of Rayleigh droplet trains substantially in parallel. ### Claim 11 (depends on 1) The aerosol generator according to claim 1, wherein the at least two first orifices and the at least one second orifice are dimensioned to obtain a total inhalation flow passing the first and second orifices of 7-20 liters per minute at inhalation underpressures ranging from 1 to 4 kPa. ### Claim 12 (depends on 1) The aerosol generator according to claim 1, wherein the second air stream creates a sheath flow that is homogeneously turbulent or laminar. ### Claim 13 (depends on 1) The aerosol generator according to claim 1, wherein the at least one second orifice is provided with at least one of a vane or a labyrinth for generating laminar flow. ### Claim 14 (depends on 1) The aerosol generator according to claim 1, wherein the at least one second orifice is provided downstream of the inlet with a fine filter mesh, filtering large eddies, with a diameter of smaller than 300 micrometers. ### Claim 15 (depends on 1) The aerosol generator according to claim 1, wherein no obstacle is provided from the nozzle to an inhalation opening of the aerosol generator. ### Claim 16 (depends on 1) The aerosol generator according to claim 1, wherein the at least two first orifices are atmospheric orifices. ### Claim 17 (depends on 1) The aerosol generator according to claim 1, wherein the aerosol generator is constructed for increasing a turbulence of the interacting first air streams in the droplet train propagation path, with an increasing inhalation under-pressure, thereby decreasing a droplet size with increasing inhalation under-pressure. ### Claim 18 (depends on 17) The aerosol generator according to claim 17, wherein the aerosol generator is constructed for decreasing a droplet size with increasing inhalation under-pressure to such an extent so as to at least partly compensate for an increasing throat deposition with increasing inhalation under-pressure. ### Claim 19 (depends on 1) The aerosol generator according to claim 1, being configured for providing the first air streams to flow from the respective first orifices along the respective mutually colliding discharging directions in straight lines into the droplet train propagation path. ### Claim 20 (depends on 1) The aerosol generator according to claim 1, being configured for providing the first air streams to interact with each other at an intersection of the discharging directions in the droplet train propagation path. ### Claim 21 An aerosol generator for generating an inhalation aerosol from an inhalation liquid, comprising: an intake duct having an outlet for guiding air to a mouth of a user and having an inlet for allowing ambient air to be drawn in while the user inhales through the device, and a nozzle, arranged for injecting the inhalation liquid into the intake duct, wherein the nozzle is arranged for generating a Rayleigh droplet train of the inhalation liquid propagating along a droplet train propagation path, and wherein the intake duct comprises: at least two first orifices, each of the at least two first orifices having a discharging direction in which respective first air streams discharge from the respective first orifices, wherein the at least two first orifices are arranged to provide the first air streams in mutually colliding discharging directions, the discharging directions of the at least two first orifices being directed towards the droplet train propagation path, the at least two first orifices being configured for providing the respective first air streams to flow from the respective first orifices along the respective mutually colliding discharging directions to and into the droplet train propagation path so as to interact with each other and with the droplet train in the droplet train propagation path, at least one second orifice having a discharge direction in which a second air stream discharges into said intake duct substantially in a longitudinal direction to said outlet of said intake duct; wherein both said at least two first orifices and said at least two second orifice communicate with said inlet; wherein a droplet size decreases with increasing air flow, and wherein the discharging directions of the at least two first orifices intersect with the droplet train propagation path at an intersection located downstream of the nozzle and before the outlet of the intake duct. ### Claim 22 (depends on 21) The aerosol generator according to claim 21, wherein the first air streams flow from the at least two first orifices in the respective discharging directions along straight lines into the droplet train propagation path.