# US 10,369,298 B2 · Skin-patch type large volume bolus drug injector with medicament pre-heating > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,298 B2 - Document ID: US10369298B2 - Status: Granted - Kind: B2 - Application number: 15/509,407 - Filed: 2015-09-11 - Published: 2017-09-14 - Granted: 2019-08-06 - Earliest claimed: 2014-09-15 - Assignees: Sanofi - Applicants: Sanofi - Inventors: Christian Nessel - Web page: https://patentgrep.com/patent/US10369298B2 ## CPC - A61M 5/445: {the media being heated in the reservoir, e.g. warming bloodbags} - A61M 5/14248: {of the skin patch type} - A61M 5/1452: {pressurised by means of pistons} - A61M 5/16813: {by controlling the degree of opening of the flow line} - A61M 5/16881: {Regulating valves} - A61M 5/172: electrical or electronic - A61M 2005/14252: {with needle insertion means} - A61M 2205/3368: Temperature - A61M 2205/3613: by body heat - A61M 2205/364: by chemical reaction - A61M 2205/3673: thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors - A61M 2205/50: with microprocessors or computers - A61M 2205/8212: with means or measures taken for minimising energy consumption - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A skin-patch type large volume drug delivery device (1) comprising a heat exchanger (24) to extract thermal energy from the body/skin surface of the user and to supply the extracted thermal energy to increase the temperature of the medicament. Alternatively or in addition, a Peltier element (35) can be used for the same purpose. The device includes a temperature sensor (31) and a controller (16) for varying the flow rate within the heat exchanger as a function of the drug temperature. ## Claims ### Claim 1 A device configured to deliver a medicament to a user by injection, comprising: a reservoir configured to hold the medicament; an injection element configured to inject the medicament from the device into a patient; and a heat exchanger configured to extract thermal energy from a body tissue of the user through a contact surface of the heat exchanger when the contact surface is in contact with a portion of skin of the user and to supply the extracted thermal energy to increase a temperature of the medicament, wherein the heat exchanger comprises a medicament flow path formed of thermally conductive material forming, at least part of, the contact surface that in use is supported against a portion of skin of the user, and wherein the medicament flow path comprises a winding path. ### Claim 2 (depends on 1) The device according to claim 1, wherein the medicament flow path comprises a liquid impermeable membrane to allow gas but not liquid medicament to be expelled through the membrane. ### Claim 3 (depends on 1) The device according to claim 1, wherein the heat exchanger comprises a Peltier element. ### Claim 4 (depends on 3) The device according to claim 3, wherein the medicament is thermally coupled to the Peltier element to act as a heat sink for the thermal energy extracted from the body tissue of the user by the Peltier element. ### Claim 5 (depends on 1) The device according claim 1, further comprising a medicament temperature sensor configured to sense a temperature of the medicament in the device. ### Claim 6 (depends on 5) The device according to claim 5, wherein the device is configured to commence delivery of the medicament in response to the temperature sensor sensing that the medicament has reached a predetermined temperature. ### Claim 7 (depends on 5) The device according to claim 5, wherein the device comprises a flow control apparatus configured to control a rate of delivery of the medicament in response to the temperature of the medicament sensed by the temperature sensor. ### Claim 8 (depends on 7) The device according to claim 7, wherein the flow control apparatus is configured to increase the rate of delivery in a manner which is proportional to increases in the temperature of the medicament sensed by the temperature sensor. ### Claim 9 (depends on 7) The device according to claim 7, wherein the flow control apparatus is configured to decrease the rate of delivery in a manner which is proportional to decreases in the temperature of the medicament sensed by the temperature sensor. ### Claim 10 (depends on 7) The device according to claim 7, wherein the flow control apparatus comprises a flow restrictor element located in the heat exchanger, the flow restrictor element configured to vary the size of a flow path through the device to vary the rate of delivery of the medicament. ### Claim 11 (depends on 7) The device according to claim 7, wherein the flow control apparatus comprises a medicament pump configured to pump medicament through the heat exchanger. ### Claim 12 (depends on 1) The device according to claim 1, wherein the medicament comprises a pharmaceutically active compound. ### Claim 13 (depends on 1) The device of claim 1, wherein the medicament flow path forms a loop. ### Claim 14 A system comprising: a device configured to deliver a medicament to a user by injection, comprising: an injection element configured to inject the medicament from the device into a patient; a heat exchanger configured to extract thermal energy from a body tissue of the user through a contact surface of the heat exchanger when the contact surface is in contact with a portion of skin of the user and to supply the extracted thermal energy to increase a temperature of the medicament; and a reservoir of medicament to be delivered into the user by injection, wherein the heat exchanger comprises a medicament flow path formed of thermally conductive material forming, at least part of, the contact surface that in use is supported against a portion of skin of the user, and wherein the medicament flow path comprises a winding path. ### Claim 15 (depends on 14) The system of claim 14, wherein the device further comprises a medicament temperature sensor configured to sense a temperatures of the medicament in the device. ### Claim 16 A method of increasing a temperature of a medicament in a device configured to deliver the medicament to a user by injection, comprising: extracting thermal energy from a body tissue of the user using through a contact surface of a heat exchanger when the contact surface is in contact with a portion of skin of the user, the heat exchanger comprising a medicament flow path formed of thermally conductive material forming, at least part of, the contact surface, wherein the medicament flow path comprises a winding path; and supplying the extracted thermal energy to increase the temperature of the medicament. ### Claim 17 (depends on 16) The method of claim 16, further comprising sensing a temperature of the medicament in the device using a temperature sensor. ### Claim 18 (depends on 17) The method of claim 17, further comprising controlling a rate of delivery of the medicament in response to the temperature of the medicament sensed by the temperature sensor.