# US 10,369,286 B2 · Drive unit for a drug delivery device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,286 B2 - Document ID: US10369286B2 - Status: Granted - Kind: B2 - Application number: 14/906,935 - Filed: 2014-07-17 - Published: 2016-06-23 - Granted: 2019-08-06 - Earliest claimed: 2013-07-25 - Assignees: Sanofi-Aventis Deutschland GmbH - Applicants: Sanofi-Aventis Deutschland GmbH - Inventors: Uwe Dasbach; George Edward Sykes; Thomas Mark Kemp - Web page: https://patentgrep.com/patent/US10369286B2 ## CPC - A61M 5/2033: {Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287)} - A61M 5/31565: {Administration mechanisms, i.e. constructional features, modes of administering a dose (dosing mechanisms for setting a dose A61M5/31533)} - A61M 2005/202: {cocking means, e.g. to bias the main drive spring of an injector} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Described is a drive unit (1) for a drug delivery device comprising a carrier (3), a plunger (4) arranged within the carrier (3) and slidable in a direction of a longitudinal axis (A), a drive spring (5) arranged for biasing the plunger (4) in a distal direction (D) relative the carrier (3), and a drive force adaption mechanism (22) for modifying a force exerted by the drive spring (5) on the plunger (4). ## Claims ### Claim 1 A drive unit for a drug delivery device, comprising: a carrier arranged within a case and axially constrained in a proximal direction with respect to the case; a plunger arranged within the carrier and slidable in a direction of a longitudinal axis; a drive spring in the shape of a compression spring arranged for biasing the plunger in a distal direction relative to the carrier; and a drive force adaption mechanism for modifying a force exerted by the drive spring on the plunger, wherein the drive force adaption mechanism is adapted to alter an initial length of the drive spring. ### Claim 2 (depends on 1) The drive unit according to claim 1, wherein the drive force adaption mechanism comprises at least one disk-shaped insert arrangeable within the case in a fixed axial position providing a backstop for the carrier. ### Claim 3 (depends on 1) The drive unit according to claim 1, wherein the drive force adaption mechanism comprises a cam arranged in the case rotatable about a transversal axis extending through the case adapted to alter the axial position of the carrier relative to the case depending on an angular position of the cam. ### Claim 4 (depends on 3) The drive unit according to claim 3, wherein a knob is arranged along the transversal axis outside the case. ### Claim 5 (depends on 1) The drive unit according to claim 1, wherein the drive force adaption mechanism comprises a gearbox arranged in the case for altering an axial position of the carrier relative to the case. ### Claim 6 (depends on 5) The drive unit according to claim 5, wherein the gearbox comprises a threaded shaft on the carrier extending in a proximal direction and passing through a first bevel gear with an internal thread. ### Claim 7 (depends on 6) The drive unit according to claim 6, wherein the first bevel gear is driven by a second bevel gear rotatable about a transversal axis extending through the case. ### Claim 8 (depends on 1) The drive unit according to claim 1, wherein the drive force adaption mechanism comprises at least one resilient beam arranged on the carrier and radially outwardly biased for engaging at least one of a series of axially consecutive notches inside the case, wherein a respective hole through the case is arranged in each notch allowing for disengaging the beam from the notch. ### Claim 9 (depends on 1) The drive unit according to claim 1, wherein the drive force adaption mechanism comprises a wedge shaped proximal end of the carrier adapted to contact a block axially fixed in the case and adapted to be transversally moved. ### Claim 10 (depends on 9) The drive unit according to claim 9, wherein the block is in a threaded engagement to a threaded transversal axis extending through the case. ### Claim 11 (depends on 1) The drive unit according to claim 1, wherein the drive force adaption mechanism comprises a case beam on the case adapted to axially overlap the case along an inner surface of the case, wherein a screw is transversally arranged through the case adapted to contact the case beam and press the case beam radially inwards onto the carrier depending on a tightening of the screw. ### Claim 12 (depends on 1) The drive unit according to claim 1, wherein the drive force adaption mechanism is adapted to introduce a friction force opposing a force of the drive spring. ### Claim 13 A drive unit for a drug delivery device, comprising: a carrier arranged within a case and axially constrained in a proximal direction with respect to the case; a plunger arranged within the carrier and slidable in a direction of a longitudinal axis; a drive spring in the shape of a compression spring arranged for biasing the plunger in a distal direction relative to the carrier; and a drive force adaption mechanism for modifying a force exerted by the drive spring on the plunger, wherein the drive force adaption mechanism is adapted to introduce a friction force opposing a force of the drive spring. ### Claim 14 A method comprising: rotating a member protruding radially outward from a housing of a drug delivery device about a transverse axis extending through the housing; the rotation of the member altering a stored spring force of a compression spring disposed within the housing; and then releasing the compression spring to advance a plunger relative to the housing in a distal direction by causing the plunger to slide in a direction of a longitudinal axis.