# US 10,369,264 B2 · Apparatus for removing chemotherapy compounds from blood > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,264 B2 - Document ID: US10369264B2 - Status: Granted - Kind: B2 - Application number: 16/127,008 - Filed: 2018-09-10 - Published: 2019-01-03 - Granted: 2019-08-06 - Earliest claimed: 2011-11-07 - Assignees: Delcath Systems, Inc. - Applicants: Delcath Systems, Inc. - Inventors: Daniel S. Johnston; Jacques Chammas; William M. Appling; Samantha J. Barton - Web page: https://patentgrep.com/patent/US10369264B2 ## CPC - A61M 1/34: Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration - A61M 1/3406: {Physical characteristics of the filtrate, e.g. urea} - A61M 1/3615: {Cleaning blood contaminated by local chemotherapy of a body part temporarily isolated from the blood circuit} - A61M 1/3687: {Chemical treatment (A61M1/3675 takes precedence)} - B01J 20/20: comprising free carbon; comprising carbon obtained by carbonising processes - B01J 20/261: {obtained by reactions only involving carbon to carbon unsaturated bonds (macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F)} - B01J 20/28011: {Other properties, e.g. density, crush strength} - B01J 20/28066: {being more than 1000 m2/g} - B01J 20/28076: {being more than 1.0 ml/g} - B01J 20/28078: {Pore diameter} - B01J 20/3078: {Thermal treatment, e.g. calcining or pyrolizing} - B01J 20/3204: {Inorganic carriers, supports or substrates} - B01J 20/327: {Polymers obtained by reactions involving only carbon to carbon unsaturated bonds} - B01J 20/3293: {Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers} - C01B 32/354: After-treatment - C01B 32/372: Coating; Grafting; Microencapsulation - A61M 2205/3306: Optical measuring means - A61M 2205/50: with microprocessors or computers - A61M 2210/1071: Liver; Hepar - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS - C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C} ## Abstract A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject. ## Claims ### Claim 1 A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject, comprising: a double balloon catheter; a filter apparatus comprising a housing having an inlet and an outlet, an extraction media comprising hemocompatible polymer coated carbon cores contained within the housing, wherein the carbon cores have a pore volume of about 1.68 cc/g to about 2.17 cc/g. ### Claim 2 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, wherein the carbon cores have a particle diameter of about 0.45 mm to about 1.15 mm. ### Claim 3 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, wherein the apparent density of carbon cores is about 0.19 g/cc to about 0.2 g/cc. ### Claim 4 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, wherein the carbon cores have a median microporous diameter (D50, micro) of between about 9.3 Å to about 10.5 Å. ### Claim 5 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, wherein the carbon cores have a median mesoporous diameter (D50,meso) of between about 30 Å to about 156 Å. ### Claim 6 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, further comprising a catheter for providing access to a hepatic artery and/or a sheath or return catheter for returning blood to a patient after the blood has been filtered to reduce the amount of chemotherapeutic agent in the blood. ### Claim 7 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, wherein the small molecule chemotherapeutic agent is melphalan hydrochloride. ### Claim 8 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, wherein the filter apparatus comprises one or more filter cartridges. ### Claim 9 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, wherein the filter apparatus comprises a dual filter cartridge wherein the dual filter cartridge comprises filter cartridges arranged in parallel. ### Claim 10 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, wherein the hemocompatible polymer coated carbon cores contained within the housing are coated with a semipermeable polymer coating comprised of material selected from the group consisting of cellulose, a methacrylate polymer, and combinations thereof. ### Claim 11 (depends on 10) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 10, wherein the semipermeable polymer coating is a methacrylate selected from the group consisting of polymethylmethacrylate (PMMA), polyethylmethacrylate (PEMA), polyhydroxyethyl-methacrylate (PHEMA) and combinations thereof. ### Claim 12 (depends on 11) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 11, wherein the semipermeable polymer coating is polyhydroxyethyl-methacrylate (PHEMA). ### Claim 13 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, wherein the subject is a human. ### Claim 14 (depends on 1) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 1, further comprising the small molecule chemotherapeutic agent melphalan hydrochloride. ### Claim 15 A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a liver of a patient, comprising: an isolation-aspiration catheter which comprises two balloons, and a filter apparatus comprising a housing having an inlet and an outlet, an extraction media comprising hemocompatible polymer coated carbon cores contained within the housing, wherein the polymer coated carbon cores wherein the carbon cores have a pore volume of about 1.68 cc/g to about 2.17 cc/g. ### Claim 16 (depends on 15) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a liver of a patient according to claim 15, further comprising a chemotherapeutic agent selected from melphalan, doxorubicin, 5-fluorouracyl 5-FU, floxuridine FURD, cisplatin, oxaliplatin, topotecan, mytomycin C, cyclophosphamide, methotrexate, vincristine, Bleomycin, FAMT, or combinations thereof. ### Claim 17 (depends on 15) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a liver of a patient according to claim 15, further comprising melphalan hydrochloride. ### Claim 18 (depends on 15) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a liver of a patient according to claim 15, further comprising an extracorporeal circuit. ### Claim 19 (depends on 15) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a liver of a patient according to claim 15, further comprising an infusion catheter. ### Claim 20 A system comprising a circuit of catheters for delivering a high concentration of a small molecule chemotherapeutic agent to a subject in need of treatment while minimizing systemic exposure to the small molecule chemotherapeutic agent, comprising: a catheter inserted percutaneously into the inferior vena cava of a patient in need of treatment, the catheter comprising a hemo-compatible tube having a cranial end and a caudal end, the hemo-compatible tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about the hemo-compatible tube and bonded thereto for inflation thereabout, one being contiguous to the cranial end, and the balloons, when inflated, having a size sufficient to block the flow of blood in a vein or artery into which the first catheter is designed to be inserted; fenestrations in the hemo-compatible tube between the balloons to the main lumen; second and third lumina within the hemo-compatible tube, the second lumen connecting to one of the balloons and the third lumen connecting to the other of the balloons, or other expandable devices, for effecting inflation or deflation of the balloons, the cranial end of the hemo-compatible tube effectively blocking inflow of blood, and a filter apparatus comprising a housing having an inlet and an outlet, an extraction media comprising hemocompatible polymer coated carbon cores contained within the housing, wherein the polymer coated carbon cores have a pore volume of about 1.68 cc/g to about 2.17 cc/g, wherein the filter apparatus is capable of being connected via a connector to the first catheter and a flow machine for pumping the blood from the subject through the filter apparatus, and a sheath or return catheter for returning blood removed from the patient back to the patient after filtration. ### Claim 21 (depends on 20) A system according to claim 20, wherein the carbon cores have a particle diameter of about 0.45 mm to about 1.15 mm. ### Claim 22 (depends on 20) A system according to claim 20, wherein the apparent density of carbon cores is about 0.19 g/cc to about 0.2 g/cc. ### Claim 23 (depends on 20) A system according to claim 20, wherein the carbon cores have a median microporous diameter (D50, micro) of between about 9.3 Å to about 10.5 Å. ### Claim 24 (depends on 20) A system according to claim 20, wherein the carbon cores have a median mesoporous diameter (D50,meso) of between about 30 Å to about 156 Å. ### Claim 25 (depends on 15) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a liver of a patient according to claim 15, wherein the carbon cores have a particle diameter of about 0.45 mm to about 1.15 mm. ### Claim 26 (depends on 15) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 15, wherein the apparent density of carbon cores is about 0.19 g/cc to about 0.2 g/cc. ### Claim 27 (depends on 15) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 15, wherein the carbon cores have a median microporous diameter (D50, micro) of between about 9.3 Å to about 10.5 Å. ### Claim 28 (depends on 15) A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a subject according to claim 15, wherein the carbon cores have a median mesoporous diameter (D50,meso) of between about 30 Å to about 156 Å.