# US 10,369,251 B2 · Anti-microbial and osteointegration nanotextured surfaces

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- Number: US 10,369,251 B2
- Document ID: US10369251B2
- Status: Granted
- Kind: B2
- Application number: 15/162,657
- Filed: 2016-05-24
- Published: 2016-09-15
- Granted: 2019-08-06
- Earliest claimed: 2012-10-19
- Assignees: Tyber Medical LLC
- Applicants: Tyber Medical LLC
- Inventors: Jeffrey Tyber; Rui J. Ferreira; Chris Faresich
- Web page: https://patentgrep.com/patent/US10369251B2

## CPC

- A61L 27/04: Metals or alloys
- A61B 17/70: Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant
- A61B 17/80: Cortical plates {, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates}
- A61B 17/8095: {Wedge osteotomy devices}
- A61B 90/94: coded with symbols, e.g. text
- A61F 2/28: Bones
- A61F 2/30767: {Special external or bone-contacting surface, e.g. coating for improving bone ingrowth}
- A61F 2/42: for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
- A61F 2/44: for the spine, e.g. vertebrae or spinal discs
- A61F 2/4455: {for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages (intervertebral discs A61F2/442)}
- A61F 2/4465: {having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine}
- A61F 2/447: {substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section}
- A61F 2/4603: {for insertion or extraction of endoprosthetic joints or of accessories thereof}
- A61F 2/4611: {of spinal prostheses}
- A61L 27/025: {Other specific inorganic materials not covered by A61L27/04 - A61L27/12}
- A61L 27/306: {Other specific inorganic materials not covered by A61L27/303 - A61L27/32}
- A61B 17/7059: {Cortical plates (A61B17/7007, A61B17/7058 take precedence)}
- A61B 17/8645: {Headless screws, e.g. ligament interference screws}
- A61B 2090/037: {with a frangible part, e.g. by reduced diameter}
- A61F 2/30771: {applied in original prostheses, e.g. holes or grooves}
- A61F 2002/2817: {Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]}
- A61F 2002/2835: {Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material}
- A61F 2002/30011: {differing in porosity}
- A61F 2002/30028: {differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts}
- A61F 2002/3008: {radio-opaque, e.g. radio-opaque markers}
- A61F 2002/30171: {rosette- or star-shaped}
- A61F 2002/30266: {wedge-shaped parallelepipeds}
- A61F 2002/30281: {wedge-shaped}
- A61F 2002/30321: {differing in roughness}
- A61F 2002/30326: {differing in height or in length}
- A61F 2002/30355: {Cylinder of elliptical or oval basis}
- A61F 2002/30471: {connected by a hinged linkage mechanism, e.g. of the single-bar or multi-bar linkage type}
- A61F 2002/30507: {using a threaded locking member, e.g. a locking screw or a set screw}
- A61F 2002/30515: {using a locking wedge or block}
- A61F 2002/30523: {by means of meshing gear teeth}
- A61F 2002/30538: {for adjusting angular orientation}
- A61F 2002/30578: {having apertures, e.g. for receiving fixation screws}
- A61F 2002/30593: {hollow}
- A61F 2002/3071: {Identification means; Administration of patients}
- A61F 2002/30733: {Inserts placed into an endoprosthetic cavity, e.g. for modifying a material property}
- A61F 2002/30774: {internally-threaded}
- A61F 2002/30808: {parallel}
- A61F 2002/3082: {Grooves}
- A61F 2002/30836: {knurled}
- A61F 2002/3084: {Nanostructures}
- A61F 2002/30843: {Pyramidally-shaped}
- A61F 2002/3092: {having an open-celled or open-pored structure}
- A61F 2002/3093: {for promoting ingrowth of bone tissue}
- A61F 2002/4627: {with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument}
- A61F 2310/00407: Coating made of titanium or of Ti-based alloys
- A61F 2310/00461: Coating made of nickel or Ni-based alloys
- A61F 2310/00796: Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
- A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
- A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

Disclosed is a medical device having a substrate having an exposed surface and a texture over at least part of the exposed surface. The texture includes a plurality of nanofeatures that inhibit bacterial adhesion on the surface and that also inhibit bacterial growth on the surface and have a size range between about 0.01 nanometers and about 1,000 nanometers. The texture can include a plurality of nanofeatures applied thereto such that the texture has a first particle size at a first location, a second particle size at a second location, and a gradient of particle size from the first particle size to the second particle size between the first location and the second location.

## Claims

### Claim 1

A medical device comprising:
a substrate having an exposed surface; and
a texture over at least part of the exposed surface, the texture comprising a plurality of nanofeatures, the nanofeatures having a first size range over a first portion of the exposed surface that produces a first property and a second size range, different from the first size range, over a second portion of the exposed surface that produces a second property, different from the first property.

### Claim 2 (depends on 1)

The medical device according to claim 1, wherein the first property inhibits bacterial adhesion on the surface.

### Claim 3 (depends on 2)

The medical device according to claim 2, wherein the first range is between about 0.01 nanometers and about 1,000 nanometers.

### Claim 4 (depends on 2)

The medical device according to claim 2, wherein the second property enhances osteointegration of the texture.

### Claim 5 (depends on 4)

The medical device according to claim 4, wherein the second range is between about 15 nanometers and about 3 millimeters.

### Claim 6

A medical device comprising:
a substrate having an exposed surface; and
a texture over at least part of the exposed surface, the texture comprising a plurality of nanofeatures applied to the exposed surface, the texture having a only first particle size at a first region, a second particle size, different from the first particle size, at a second region, and a gradient of particle size from the first particle size to the second particle size between the first region and the second region.

### Claim 7 (depends on 6)

The medical device according to claim 6, wherein the nanofeatures at the first region have a first shape, and wherein the nanofeatures at the second region have a second shape, different from the first shape.

### Claim 8 (depends on 6)

The medical device according to claim 6, wherein the nanofeatures at the first region have a first size range and wherein the nanofeatures at the second region have a second size range, different from the first size range.

### Claim 9 (depends on 6)

The medical device according to claim 6, wherein the first particle size is sized to enhance osteoconductivity and wherein the second particle size is sized to enhance anti-bacterial properties.