# US 10,369,194 B2 · Methods to treat allergic conditions with PIM1 kinase inhibitor

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- Number: US 10,369,194 B2
- Document ID: US10369194B2
- Status: Granted
- Kind: B2
- Application number: 15/664,550
- Filed: 2017-07-31
- Published: 2018-01-18
- Granted: 2019-08-06
- Earliest claimed: 2010-11-10
- Assignees: National Jewish Health
- Applicants: National Jewish Health
- Inventors: Erwin W. Gelfand; Meiqin Wang
- Web page: https://patentgrep.com/patent/US10369194B2

## CPC

- A61K 38/1719: {Muscle proteins, e.g. myosin or actin}
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 31/4045: Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A61K 31/553: having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A61K 31/7052: having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/02: Nasal agents, e.g. decongestants
- A61P 11/06: Antiasthmatics
- A61P 17/00: Drugs for dermatological disorders
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits Pim kinase. Also disclosed are methods to treat allergic conditions in a subject by administering a composition that induces expression of Runx3.

## Claims

### Claim 1

A method to treat airway inflammation in a subject who has airway inflammation, comprising administering to the subject an effective amount of a composition comprising a Pim1 kinase inhibitor, wherein the Pim1 kinase inhibitor is AR460770.

### Claim 2 (depends on 1)

The method of claim 1, wherein the airway inflammation is selected from the group consisting of allergic rhinitis, asthma, airway hyperresponsiveness, hay fever, airborne allergic sensitivities, and hypersensitivity pneumonitis.

### Claim 3 (depends on 1)

The method of claim 1, wherein the subject has been sensitized to an allergen and has been exposed to the allergen.

### Claim 4 (depends on 1)

The method of claim 1, wherein administration of the Pim1 kinase inhibitor induces expression of Runx3.

### Claim 5 (depends on 1)

The method of claim 1, wherein administration of the Pim1 kinase inhibitor reduces or suppresses CD4+ and CD8+ cell proliferation, Th2 differentiation, or Th17 differentiation.