# US 10,369,185 B2 · Methods and compositions for enhancement of ability to concentrate

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- Number: US 10,369,185 B2
- Document ID: US10369185B2
- Status: Granted
- Kind: B2
- Application number: 15/312,882
- Filed: 2015-05-22
- Published: 2017-07-06
- Granted: 2019-08-06
- Earliest claimed: 2014-05-23
- Assignees: Kyowa Hakko Bio Co., Ltd.
- Applicants: Kyowa Hakko Bio Co., Ltd.
- Inventors: Yukihiro Hishida; Takeshi Ikeda; Ryusuke Nakagiri; Ayako Kamimura
- Web page: https://patentgrep.com/patent/US10369185B2

## CPC

- A61K 38/05: Dipeptides
- A23L 2/52: Adding ingredients (adding preservatives A23B70/10)
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61P 25/00: Drugs for disorders of the nervous system
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A composition for enhancement of ability to concentrate and method of improving ability to concentrate using alanylglutamine or a salt of alanylglutamine as an active ingredient.

## Claims

### Claim 1

A method of improving ability to concentrate in a subject performing an endurance activity, comprising the step of administering a fluid comprising an effective amount of alanylglutamine or a salt thereof to the subject, wherein the amount of fluid comprising the effective amount of alanylglutamine or a salt thereof consumed by the subject is less than the amount of fluid lost by the subject during the activity.

### Claim 2 (depends on 1)

The method of claim 1, wherein the alanylglutamine or salt thereof is administered in an amount of 5 mg or more and 10,000 mg or less per day.

### Claim 3 (depends on 1)

The method of claim 1, wherein the alanylglutamine or salt thereof is administered in an amount of 50 mg or more and 5,000 mg or less per day.

### Claim 4 (depends on 1)

The method of claim 1, wherein the alanylglutamine or salt thereof is administered in an amount of 500 mg or more and 3,000 mg or less per day.

### Claim 5 (depends on 1)

The method of claim 1, wherein the fluid comprises alanylglutamine or salt thereof in a concentration of 600 mg/L or more and 2 g/L or less.

### Claim 6 (depends on 1)

The method of claim 1, wherein the endurance activity is an endurance exercise lasting at least 60 minutes.