# US 10,369,184 B2 · Composition and use thereof in manufacture of product for improving intestinal function

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- Number: US 10,369,184 B2
- Document ID: US10369184B2
- Status: Granted
- Kind: B2
- Application number: 15/467,146
- Filed: 2017-03-23
- Published: 2018-01-25
- Granted: 2019-08-06
- Earliest claimed: 2016-07-21
- Assignees: Infinitus (China) Company Ltd.
- Applicants: Infinitus (China) Company Ltd.
- Inventors: Xin Jin; Yazhong Ge; Chung Wah Ma; Chuixin Qin
- Web page: https://patentgrep.com/patent/US10369184B2

## CPC

- A61K 36/8945: Dioscorea, e.g. yam, Chinese yam or water yam
- A61K 31/733: Fructosans, e.g. inulin
- A61K 35/745: Bifidobacteria
- A61K 35/747: Lactobacilli, e.g. L. acidophilus or L. brevis
- A61K 36/734: Crataegus (hawthorn)
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/12: Antidiarrhoeals
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to the technical field of health care products, in particular to a composition and use thereof in the manufacture of a product for improving intestinal function. The present invention provides a composition and use thereof in the manufacture of a product for improving intestinal function. In the present invention, probiotics, prebiotics, Crataegi Fructus and Dioscoreae Rhizoma are reasonably compounded, wherein each component acts synergistically, thus allowing the obtained composition to have good effects of preventing and/or treating diarrhea as well as improving intestinal flora. The efficacy thereof is significantly superior to (P<0.05) that of the Comparative Examples.

## Claims

### Claim 1

A composition, comprising probiotics, prebiotics, Crataegi fructus and Dioscoreae rhizoma, wherein the mass ratio of the probiotics, the prebiotics, the Crataegi fructus and the Dioscoreae rhizoma is (2.0-40.0):(30.0-96.0):(1.0-30.0):(1.0-30.0), the probiotics are selected from Lactobacillus and Bifidobacterium, and the prebiotics are inulin.

### Claim 2 (depends on 1)

The composition according to claim 1, wherein the probiotics are Lactobacillus and Bifidobacterium, the mass ratio of the Lactobacillus to the Bifidobacterium is (2.0-20.0):(2.0-20.0).

### Claim 3 (depends on 1)

The composition according to claim 1, wherein the probiotics are added in an amount of 106 CFU/g-1012 CFU/g based on the total weight of the composition.

### Claim 4 (depends on 1)

A method for treating diarrhea, comprising administering the composition of claim 1.

### Claim 5 (depends on 4)

The method according to claim 4, wherein the diarrhea is antibiotic-associated diarrhea and/or diarrhea induced by spleen deficiency.

### Claim 6 (depends on 1)

A product for treating diarrhea, comprising the composition of claim 1.

### Claim 7 (depends on 1)

A method for improving intestinal flora, comprising administering the composition of claim 1.

### Claim 8 (depends on 7)

The method according to claim 7, wherein the improving intestinal flora is improving intestinal flora disorder induced by antibiotics administration and/or improving intestinal flora disorder induced by spleen deficiency.

### Claim 9 (depends on 1)

A product for improving intestinal flora, comprising the composition of claim 1.