# US 10,369,180 B2 · Composition comprising retinol, a precursor or a reaction product of it and a plant extract from at least one Chamomilla plant for the treatment of cancer

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,369,180 B2
- Document ID: US10369180B2
- Status: Granted
- Kind: B2
- Application number: 15/849,109
- Filed: 2017-12-20
- Published: 2018-05-03
- Granted: 2019-08-06
- Earliest claimed: 2010-08-05
- Assignees: Alpinia Laudanum Institute of Phytopharmaceutical Sciences AG
- Applicants: Alpinia Laudanum Institute of Phytopharmaceutical Sciences AG
- Inventors: Matthias H. Kreuter; Jianying Yam
- Web page: https://patentgrep.com/patent/US10369180B2

## CPC

- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 31/07: Retinol compounds, e.g. vitamin A (retinoic acids A61K31/203)
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/203: Retinoic acids {; Salts thereof}
- A61K 31/215: of carboxylic acids
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 35/04: specific for metastasis
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to a (i) Vitamin A, a reaction product, a metabolite or a precursor of it and (ii) a plant extract of chamomile or an active component thereof, preferably for use in the treatment of cancer. The inventive composition may be provided as a medicament or a pharmaceutical composition. The at least one Chamomilla plant typically contained in the inventive compositions preferably comprises Matricaria recutita, more preferably flores tubiformis of Matricaria recutita. Esters of Retinol typically contained in the inventive compositions typically comprise e.g. Retinyl acetate and a plant extract from the plant Matricaria recutita.

## Claims

### Claim 1

A method of treating a human suffering from lung cancer or brain cancer consisting essentially of administering a therapeutically effective amount of an ethanol chamomile extract from tubular flowers of Matricaria recutita and vitamin A to said human suffering from said lung cancer or brain cancer to effectively treat the lung cancer or brain cancer in said human in need thereof.

### Claim 2 (depends on 1)

A method according to claim 1, wherein the administering is via the respiratory tract, via oral administration, via injection, or via parenteral injection of the human in need thereof.

### Claim 3 (depends on 1)

A method according to claim 1, wherein the method further consists essentially of dimethyl sulphoxide, diethylene glycol monoethyl ether, or a mixture thereof.

### Claim 4 (depends on 1)

A method according to claim 1, wherein the amount of the ethanol chamomile extract from tubular flowers of Matricaria recutita is about 50 mg to about 1500 mg and the amount of the Vitamin A is about 3 mg to about 90 mg.