# US 10,369,178 B2 · Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use

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- Number: US 10,369,178 B2
- Document ID: US10369178B2
- Status: Granted
- Kind: B2
- Application number: 15/451,377
- Filed: 2017-03-06
- Published: 2019-01-24
- Granted: 2019-08-06
- Earliest claimed: 2016-03-06
- Assignees: Resurgent Pharmaceuticals, Inc.
- Applicants: Resurgent Pharmaceuticals, Inc.
- Inventors: Eric Greenbaum; Kyle Kingsley
- Web page: https://patentgrep.com/patent/US10369178B2

## CPC

- A61K 36/3482: {Cannabis}
- A24B 3/12: Steaming, curing, or flavouring tobacco
- A24B 15/302: {by natural substances obtained from animals or plants}
- A24B 15/303: {Plant extracts other than tobacco}
- A24D 1/002: {with additives, e.g. for flavouring}
- A24D 3/14: of organic materials as additive (of ion exchange materials A24D3/12)
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 2236/37: Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
- A61K 2236/39: Complex extraction schemes, e.g. fractionation or repeated extraction steps
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A24B: MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24D: CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES OF CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES

## Abstract

A substantially pure fraction of at least one cannabinoid is added to smokable or smokeless tobacco products to reduce the harm associated with tobacco use. The harm to be reduced includes irritation and carcinogenicity of tobacco. In a preferred embodiment a whole plant cannabis extract is mixed directly with the tobacco during the curing or manufacturing process. For cigarette applications the cannabinoids may be inserted into a cigarette filter, and/or paper. In other embodiments the cannabinoids are purified.

## Claims

### Claim 1

A method for reducing the harmful effects of tobacco use in a human in need thereof consisting essentially of administering to the human in need thereof tobacco and a microencapsulated highly purified isolate of a cannabinoid from cannabis to effectively reduce the harmful effects of tobacco use in the human in need thereof, wherein said cannabinoid is selected from the group consisting of tetrahydrocannabinol, cannabidiol and mixtures thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein tetrahydrocannabinol and cannabidiol are present in a ratio of about 1:20, tetrahydrocannabinol: cannabidiol, when used as a mixture.

### Claim 3 (depends on 1)

The method of claim 1, wherein said tobacco is in a form selected from the group consisting of cigarettes, cigars, chewing tobacco, and moist snuff.