Probiotic formulations and methods for use
AssigneesResearch Institute At Nationwide Children's Hospital, Ohio State Innovation Foundation
InventorsSteven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
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Abstract
Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
Claims27
A composition comprising a biocompatible microsphere, a prebiotic, and a biofilm-generating probiotic bacterium that releases a DNABII protein, wherein the prebiotic comprises an effective amount of a nutritional supplementation for the probiotic bacterium to support the formation of a biofilm, and wherein the prebiotic diffuses from within the microsphere.
A composition consisting essentially of a biocompatible microsphere, a prebiotic, and a probiotic bacterium that releases a DNABII protein, wherein the prebiotic comprises a nutritional supplementation for the probiotic bacterium, and the probiotic bacterium and the prebiotic are provided in an amount effective to support the formation of a biofilm adhered to the surface of the microsphere, and wherein the prebiotic diffuses from within the microsphere.
A composition consisting essentially of 1) a biocompatible microsphere, 2) a probiotic bacterium that releases a DNABII protein, 3) a prebiotic, wherein the prebiotic comprises a nutritional supplementation for the probiotic bacterium, and the probiotic bacterium and the prebiotic are provided in an amount effective to support the formation of a biofilm on the surface of the microsphere, and 4) a biofilm adhered to the surface of the microsphere, wherein the prebiotic diffuses from within the microsphere.
Dependencies are inferred from the claim text.