# US 10,369,163 B2 · Anti-fatigue composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,163 B2 - Document ID: US10369163B2 - Status: Granted - Kind: B2 - Application number: 15/093,207 - Filed: 2016-04-07 - Published: 2016-10-06 - Granted: 2019-08-06 - Earliest claimed: 2013-10-09 - Assignees: Ajinomoto Co., Inc. - Applicants: Ajinomoto Co., Inc. - Inventors: Tetsuro Shibakusa; Mayu Sugita - Web page: https://patentgrep.com/patent/US10369163B2 ## CPC - A61K 31/675: having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate - A23L 2/52: Adding ingredients (adding preservatives A23B70/10) - A23L 2/56: Flavouring or bittering agents (sweeteners A23L2/60) - A23L 2/66: Proteins - A23L 33/15: Vitamins - A23L 33/175: Amino acids - A23L 33/18: Peptides; Protein hydrolysates - A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration} - A61K 31/4164: 1,3-Diazoles - A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine - A61K 31/4415: Pyridoxine, i.e. Vitamin B6 (pyridoxal phosphate A61K31/675) - A61P 3/02: Nutrients, e.g. vitamins, minerals - A61P 39/02: Antidotes - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract Compositions and foods which contain (1) histidine and (2) vitamin B6 and/or carnosine are useful for treating, improving, and recovering from fatigue. ## Claims ### Claim 1 An anti-fatigue composition, comprising (1) histidine and (2) vitamin B6 in combination, wherein: said composition is contained in a unit package; said histidine is present in said unit package in an amount of not less than 0.5 g per said unit package; and said vitamin B6 is present in said unit package in an amount of not less than 15 mg per said unit package and said histidine and said vitamin B6 are present in a histidine:vitamin B6 weight ratio of about 120:1. ### Claim 2 (depends on 1) The composition according to claim 1, further comprising carnosine. ### Claim 3 (depends on 2) The composition according to claim 2, which comprises said histidine and said carnosine in a histidine:carnosine weight ratio of about 1:4. ### Claim 4 (depends on 1) The composition according to claim 1, wherein said unit package comprises written indicia that the amount of histidine to be ingested is not less than 0.05 g. ### Claim 5 (depends on 1) The composition according to claim 1, further comprising at least one kind of additive selected from the group consisting of an excipient, a corrigent, and a flavor. ### Claim 6 (depends on 1) The composition according to claim 1, which is in the form of a solid, a semi-solid, or a liquid. ### Claim 7 (depends on 1) The composition according to claim 1, which is in the form of a powder, a tablet, granule, or a capsule. ### Claim 8 (depends on 1) The composition according to claim 1, which is in the form of a slurry, a solution, a jelly, or an emulsion. ### Claim 9 (depends on 1) A method for treating, improving, or recovering from fatigue, comprising administering to a subject in need thereof an effective amount of a composition according to claim 1. ### Claim 10 (depends on 9) The method according to claim 9, wherein said composition further comprises carnosine. ### Claim 11 A container-packed food, comprising (1) histidine and (2) vitamin B6, wherein: said histidine is present in said container in an amount of not less than 0.5 g; and said vitamin B6 is present in said container in an amount of not less than 15 mg and said histidine and said vitamin B6 are present in a histidine:vitamin B6 weight ratio of about 120:1. ### Claim 12 (depends on 11) The container-packed food according to claim 11, further comprising carnosine. ### Claim 13 (depends on 12) The container-packed food according to claim 12, wherein said container comprises written indicia that the amount of histidine to be ingested is not less than 0.5 g. ### Claim 14 (depends on 11) The container-packed food according to claim 11, further comprising at least one kind of additive selected from the group consisting of an excipient, a corrigent, and a flavor. ### Claim 15 (depends on 11) The container-packed food according to claim 11, which is in the form of a solid, a semi-solid, or a liquid. ### Claim 16 (depends on 11) The container-packed food according to claim 11, which is in the form of a powder, a tablet, a granule or a capsule. ### Claim 17 (depends on 11) The container-packed food according to claim 11, which is in the form of a slurry, a solution, a jelly or an emulsion. ### Claim 18 (depends on 11) The container-packed food according to claim 11, which is in a unit package form for a single administration of said food. ### Claim 19 (depends on 11) A container-packed food according to claim 11, which is a drink. ### Claim 20 (depends on 19) The container-packed food according to claim 19, further comprising carnosine. ### Claim 21 (depends on 19) The container-packed food according to claim 19, wherein said histidine is present in an amount of not less than 1 w/v %. ### Claim 22 (depends on 19) The container-packed food according to claim 19, which is in a unit package form. ### Claim 23 An anti-fatigue composition, consisting of: (a) histidine; (b) vitamin B6; and (c) one or more ingredients selected from the group consisting of ascorbic acid, a salt of ascorbic acid, tartaric acid, a salt of tartaric acid, citric acid, a salt of citric acid, malic acid, a salt of malic acid, aspartame, stevia, sucralose, glycyrrhizinic acid, thaumatin, acesulfame potassium, saccharin, saccharin sodium, L-menthol, orange oil, lemon oil, lime oil, grapefruit oil, a flower essential oil, peppermint oil, spearmint oil, spice oil, lactose, sucrose, D-mannitol, starch, cornstarch, crystalline cellulose, light anhydrous silicic acid, magnesium stearate, calcium stearate, talc, and colloidal silica. ### Claim 24 (depends on 23) The anti-fatigue composition according to claim 23, wherein said histidine is present in a unit package in an amount of not less than 0.5 g per said unit package; and said vitamin B6 is present in said unit package in an amount of not less than 15 mg per said unit package; and said histidine and said vitamin B6 are present in a histidine:vitamin B6 weight ratio of 90:1 to 120:1. ### Claim 25 (depends on 23) The anti-fatigue composition according to claim 23, wherein said histidine and said vitamin B6 are present in a histidine:vitamin B6 weight ratio of about 120:1.