# US 10,369,151 B2 · Treatment or prevention of autism disorders using menthol, linalool and/or icilin

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- Number: US 10,369,151 B2
- Document ID: US10369151B2
- Status: Granted
- Kind: B2
- Application number: 14/892,038
- Filed: 2014-05-23
- Published: 2016-03-31
- Granted: 2019-08-06
- Earliest claimed: 2013-05-24
- Assignees: Societe des Produits Nestle S.A.
- Applicants: Nestec S.A.
- Inventors: Susana Camacho; Stephanie Michlig Gonzalez; Johannes Le Coutre; Henry Markram; Maurizio Pezzoli
- Web page: https://patentgrep.com/patent/US10369151B2

## CPC

- A61K 31/513: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Compositions for treatment or prevention of autism disorders are provided, and the compositions contain a therapeutically effective amount of a compound selected from the group consisting of Menthol, Linalool, Icilin and combinations thereof. Methods for treatment or prevention of autism disorders are also provided, and the methods include administering such compositions.

## Claims

### Claim 1

A method for treating an autism disorder comprising administering to an individual having the autism disorder a composition comprising Menthol, and the composition is administered daily in an amount that provides a daily dose of the Menthol from 10.0 mg/kg of body weight of the individual to 100.0 mg/kg of body weight of the individual.

### Claim 2 (depends on 1)

The method of claim 1 wherein the autism disorder is selected from the group consisting of classic autism, Asperger's syndrome, childhood disintegrative disorder, Rett syndrome, pervasive developmental disorders-not otherwise specified, fragile X syndrome, and combinations thereof.

### Claim 3 (depends on 1)

The method of claim 1 wherein the composition is selected from the group consisting of a medicament, a food product and a supplement to a food product.

### Claim 4 (depends on 1)

The method of claim 1 wherein the composition is administered daily for at least one year.

### Claim 5 (depends on 1)

The method of claim 1 wherein the individual is an infant.

### Claim 6 (depends on 1)

The method of claim 1 wherein the individual is a young child.

### Claim 7 (depends on 1)

The method of claim 1 wherein the composition is administered for at least two years.

### Claim 8 (depends on 1)

The method of claim 1 wherein the composition further comprises protective hydrocolloids.

### Claim 9 (depends on 1)

The method of claim 1 wherein the composition is a food product.

### Claim 10 (depends on 9)

The method of claim 9 wherein the food product comprises a component selected from the group consisting of protein, carbohydrate, fat and combinations thereof.

### Claim 11 (depends on 1)

The method of claim 1 wherein the composition does not contain glutamate antagonists.

### Claim 12 (depends on 1)

The method of claim 1 wherein the composition is a food product consisting of the Menthol and optionally one or more components selected from the group consisting of protein, carbohydrate, fat, an acidulant, a thickener, a buffer, a pH adjustment agent, a chelating agent, a colorant, an emulsifier, an excipient, a flavor agent, a mineral, an osmotic agent, a pharmaceutically acceptable carrier, a preservative, a stabilizer, a sugar, a sweetener, a texturizer and a vitamin.

### Claim 13 (depends on 1)

The method of claim 1 wherein the composition is a food supplement consisting of the Menthol and optionally one or more components selected from the group consisting of a gum, a protein, a modified starch, a binder, a film forming agent, an encapsulating agent, a wall or shell material, a matrix compound, a coating, an emulsifier, a surface active agent, an oil, a fat, a wax, lecithin, an adsorbent, a carrier, a filler, a co-compound, a dispersing agent, a wetting agent, a solvents, a flowing agent, a taste masking agent, a weighting agent, a jellifying agent, and a gel forming agent.