4-(2-amino-tetrahydronaphthalenyl)pyrimidine derivative, preparation method therefor, and pharmaceutical composition for preventing or treating cancer, containing same as active ingredient

A compound represented by formula 1 or a pharmaceutically acceptable salt of the same:

• In the formula 1,
• R1a, R1b, R2a and R2b are independently hydrogen or C1-5 straight or branched alkyl, and R1a and R1b or R2a and R2b can form oxo group (═O);
• indicates either single bond or double bond;
• when is single bond,
• X is —OH or —NR3R4, wherein, R3 and R4 are independently hydrogen, C1-5 straight or branched alkyl, —(C═NH)—R5, or —(C═O)(CH2)nR5, wherein, R5 is hydrogen, methyl, —OH, —N(CH3)2, —NH2, or trihalomethyl, and n is an integer of 0-3,
• R3 and R4 can form 5-8 membered unsubstituted or substituted heterocycloalkyl containing one or more hetero atoms selected from the group consisting of N, O, and S along with the nitrogen atoms conjugated to the same;
• when is double bond,
• X is ═O, ═N—OH or ═N—NR6R7, wherein, R6 and R7 are independently hydrogen, C1-5 straight or branched alkyl, —(C═O)R8 or —(C═NH)R8, wherein, R8 is methyl, —NH2 or C1-5 straight or branched alkoxy,
• R6 and R7 can form 5-8 membered unsubstituted or substituted heterocycloalkyl containing one or more hetero atoms selected from the group consisting of N, O, and S along with the nitrogen atoms conjugated to the same, and the substituted heterocycloalkyl can be substituted with —(C═O)CF3 or C1-5 straight or branched alkyl.