# US 10,369,125 B2 · Method of treating renal system damage

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- Number: US 10,369,125 B2
- Document ID: US10369125B2
- Status: Granted
- Kind: B2
- Application number: 15/492,732
- Filed: 2017-04-20
- Published: 2018-04-05
- Granted: 2019-08-06
- Earliest claimed: 2008-06-19
- Assignees: University of Utah Research Foundation
- Applicants: University of Utah Research Foundation
- Inventors: Tianxin Yang
- Web page: https://patentgrep.com/patent/US10369125B2

## CPC

- A61K 31/201: having one or two double bonds, e.g. oleic, linoleic acids
- A61K 31/231: having one or two double bonds
- A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.

## Claims

### Claim 1

A method of treating renal system damage in a subject, comprising:
administering to the subject an effective amount of a nitrated fatty acid,
wherein the renal system damage is selected from the group consisting of distortion of the overall renal morphology, appearance of protein cast, oxidative stress, and apoptosis of organ cells; and
wherein the nitrated fatty acid is 10-nitro oleic acid.

### Claim 2 (depends on 1)

The method of claim 1, wherein the renal system damage is distortion of the overall renal morphology.

### Claim 3 (depends on 1)

The method of claim 1, wherein the renal system damage is appearance of protein cast.

### Claim 4 (depends on 1)

The method of claim 1, wherein the renal system damage is oxidative stress.

### Claim 5 (depends on 2)

The method of claim 2, wherein the renal system damage is apoptosis of organ cells.