# US 10,369,116 B2 · Patch comprising an adhesive layer having a nonfunctional silicone oil

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- Number: US 10,369,116 B2
- Document ID: US10369116B2
- Status: Granted
- Kind: B2
- Application number: 15/554,923
- Filed: 2016-02-22
- Published: 2018-03-29
- Granted: 2019-08-06
- Earliest claimed: 2015-03-02
- Assignees: Hisamitsu Pharmaceutical Co., Inc.
- Applicants: Hisamitsu Pharmaceutical Co., Inc.
- Inventors: Yoko Fujiwara; Takashi Yasukochi; Yuka Takagi
- Web page: https://patentgrep.com/patent/US10369116B2

## CPC

- A61K 9/7061: {Polyacrylates}
- A61K 9/7069: {obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide}
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A patch includes an adhesive layer and a release liner laminated on at least one surface of a backing. The adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives, and the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25° C.

## Claims

### Claim 1

A patch comprising an adhesive layer and a release liner laminated on at least one surface of a backing, wherein
the adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives,
the adhesive layer comprises, as a plasticizer, at least one selected from the group consisting of liquid paraffin, liquid polybutene, isopropyl palmitate, isopropyl myristate, diethyl sebacate, and hexyl laurate,
the adhesive layer comprises, as a transdermal absorption enhancer, at least one selected from the group consisting of fatty acids having a carbon chain of 6 to 20 carbon atoms and aliphatic alcohols having a carbon chain of 6 to 20 carbon atoms, and
the adhesive layer comprises 0.3 to 3% by mass of a nonfunctional silicone oil having a kinematic viscosity of 20 to 250 cSt at 25° C. wherein the nonfunctional silicone oil is at least one selected from the group consisting of dimethylpolysiloxane and methylphenylpolysiloxane.

### Claim 2 (depends on 1)

The patch according to claim 1, wherein
the adhesive layer further comprises a drug.

### Claim 3 (depends on 1)

The patch according to claim 1, wherein
the adhesive layer further comprises, as a tackifier, at least one selected from the group consisting of hydrogenated rosin glycerol esters, alicyclic saturated hydrocarbon resins, aliphatic hydrocarbon resins, and terpene resins.

### Claim 4 (depends on 1)

The patch according to claim 1, wherein
the adhesive base agent is an acrylate ester-based copolymer, and
the adhesive layer further comprises a liquid fatty acid ester and a fatty acid having a carbon chain of 6 to 20 carbon atoms.

### Claim 5 (depends on 1)

The patch according to claim 1, wherein
the adhesive base agent comprises a styrene-isoprene-styrene block copolymer and polyisobutylene, and
the adhesive layer further comprises an alicyclic saturated hydrocarbon resin, a petroleum-based oil, a liquid fatty acid ester, and an aliphatic alcohol having a carbon chain of 6 to 20 carbon atoms.