# US 10,369,115 B2 · Cataplasm and method for producing the same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,115 B2 - Document ID: US10369115B2 - Status: Granted - Kind: B2 - Application number: 14/913,455 - Filed: 2014-08-21 - Published: 2016-07-21 - Granted: 2019-08-06 - Earliest claimed: 2013-08-23 - Assignees: Hisamitsu Pharmaceutical Co., Inc. - Applicants: Hisamitsu Pharmaceutical Co., Inc. - Inventors: Keiichiro Tsurushima; Yasuhisa Kose; Shinji Yamasoto; Seiichiro Tsuru; Takaaki Yoshinaga - Web page: https://patentgrep.com/patent/US10369115B2 ## CPC - A61K 9/7061: {Polyacrylates} - A61L 15/225: {Mixtures of macromolecular compounds} - A61L 15/585: {Mixtures of macromolecular compounds} - A61L 15/60: Liquid-swellable gel-forming materials, e.g. super-absorbents - C08F 220/14: Methyl esters {, e.g. methyl (meth)acrylate} - C08L 33/02: Homopolymers or copolymers of acids; Metal or ammonium salts thereof - C08L 71/00: Compositions of polyethers obtained by reactions forming an ether link in the main chain (of polyacetals C08L59/00; of epoxy resins C08L63/00; of polythioether-ethers C08L81/02; of polyether-sulfones C08L81/06); Compositions of derivatives of such polymers - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS - C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06) ## Abstract A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid. ## Claims ### Claim 1 A gel patch, comprising: a plaster layer on a support, the plaster layer comprising: a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion comprises poly(methyl acrylate/2-ethylhexyl acrylate) and water as a medium, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% at or above the boiling point of the medium and is present in an amount ranging between 2.5 times and 10 times inclusive a mass of the neutralized polyacrylic acid; and a polyacrylic acid in the amount of 1-5 mass % based on the total mass of the plaster layer, wherein the neutralized polyacrylic acid present in the plaster layer is 1 to 6 mass %, based on a total mass of the plaster layer; wherein the gel patch has an adhesive force based on an adhesive force of the poly(methyl acrylate/2-ethylhexyl acrylate) in the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion and an adhesive force of the neutralized polyacrylic acid, and wherein upon application, the adhesive force of the neutralized polyacrylic acid is greater than the adhesive force of the poly(methyl acrylate/2-ethylhexyl acrylate), and the adhesive force of the poly(methyl acrylate/2-ethylhexyl acrylate) increases to become greater than the adhesive force of the neutralized polyacrylic acid as the amount of water in the plaster layer is reduced. ### Claim 2 (depends on 1) The gel patch according to claim 1, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion comprises poly(oxyethylene)nonylphenyl ether. ### Claim 3 (depends on 1) The gel patch according to claim 1, wherein the neutralized polyacrylic acid is partially neutralized polyacrylic acid. ### Claim 4 (depends on 1) The gel patch according to claim 1, wherein the water present in the plaster layer is greater by mass than the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion present in the plaster layer. ### Claim 5 (depends on 1) The gel patch according to claim 1, wherein the water present in the plaster layer is at least 4 times greater by mass than the neutralized polyacrylic acid present in the plaster layer. ### Claim 6 (depends on 1) The gel patch according to claim 1, wherein the neutralized polyacrylic acid, the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion and the water are mixed in a mass ratio of neutralized polyacrylic acid:poly(methyl acrylate/2-ethylhexyl acrylate) emulsion:water=1:2.5-7:5-16. ### Claim 7 (depends on 6) The gel patch according to claim 6, wherein the mass ratio of neutralized polyacrylic acid:poly(methyl acrylate/2-ethylhexyl acrylate) emulsion:water=1:2.5-7:7-16. ### Claim 8 (depends on 1) The gel patch according to claim 1, wherein the water present in the plaster layer is 20 to 60 mass % of a total mass of the plaster layer. ### Claim 9 (depends on 1) The gel patch according to claim 1, wherein a plaster layer mass is 214 to 1000 g/m2. ### Claim 10 (depends on 1) The gel patch according to claim 1, wherein the amount of water in the plaster layer is reduced by evaporation. ### Claim 11 (depends on 1) A method of producing a gel patch according to claim 1, having an adhesive force and comprising a plaster layer on a support, the method comprising: mixing water, a neutralized polyacrylic acid, a polyacrylic acid, and a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is in an amount ranging between 2.5 times and 10 times inclusive a mass of the neutralized polyacrylic acid to obtain the plaster layer, wherein the adhesive force of the gel patch can be maintained even with a reduction of water content. ### Claim 12 (depends on 2) The gel patch according to claim 2, wherein the neutralized polyacrylic acid is partially neutralized polyacrylic acid. ### Claim 13 (depends on 2) The gel patch according to claim 2, wherein the water present in the plaster layer is greater by mass than the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion present in the plaster layer. ### Claim 14 (depends on 3) The gel patch according to claim 3, wherein the water present in the plaster layer is greater by mass than the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion present in the plaster layer. ### Claim 15 (depends on 2) The gel patch according to claim 2, wherein the water present in the plaster layer is at least 4 times greater by mass than the neutralized polyacrylic acid present in the plaster layer. ### Claim 16 (depends on 3) The gel patch according to claim 3, wherein the water present in the plaster layer is at least 4 times greater by mass than the neutralized polyacrylic acid present in the plaster layer. ### Claim 17 (depends on 4) The gel patch according to claim 4, wherein the water present in the plaster layer is at least 4 times greater by mass than the neutralized polyacrylic acid present in the plaster layer. ### Claim 18 (depends on 2) The gel patch according to claim 2, wherein the neutralized polyacrylic acid, the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion and the water are mixed in a mass ratio of neutralized polyacrylic acid:poly(methyl acrylate/2-ethylhexyl acrylate) emulsion:water=1:2.5-7:5-16.