# US 10,369,091 B2 · Core shell silica particles and uses thereof as an anti-bacterial agent

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- Number: US 10,369,091 B2
- Document ID: US10369091B2
- Status: Granted
- Kind: B2
- Application number: 15/106,445
- Filed: 2014-12-18
- Published: 2016-11-24
- Granted: 2019-08-06
- Earliest claimed: 2013-12-20
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Guisheng Pan; Suman Chopra
- Web page: https://patentgrep.com/patent/US10369091B2

## CPC

- A61K 8/25: Silicon; Compounds thereof
- A61K 8/022: {Powders; Compacted Powders}
- A61K 8/0241: {Containing particulates characterized by their shape and/or structure (see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes)}
- A61K 8/0245: {Specific shapes or structures not provided for by any of the groups of A61K8/0241}
- A61K 8/0258: {Layered structure}
- A61K 8/19: containing inorganic ingredients
- A61K 8/466: {containing sulfonic acid derivatives; Salts}
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- C01B 33/18: Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof (preparation of aerogels by dehydrating gels C01B33/158; treatment to enhance the pigmenting or filling properties C09C)
- C03C 15/00: Surface treatment of glass, not in the form of fibres or filaments, by etching (etching or surface-brightening compositions, in general C09K13/00)
- C03C 17/22: with other inorganic material (C03C17/34, C03C17/44 take precedence)
- C03C 17/23: Oxides (C03C17/02 takes precedence)
- C09C 1/3054: {Coating}
- C09K 3/1436: {Composite particles, e.g. coated particles}
- C09K 3/1445: {the coating consisting exclusively of metals}
- A61K 2800/28: Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
- A61K 2800/621: by inorganic compounds
- A61K 2800/651: The particulate/core comprising inorganic material
- A61K 2800/92: Oral administration
- C01P 2004/61: Micrometer sized, i.e. from 1-100 micrometer
- C01P 2004/84: one phase coated with the other
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C}
- C03C: CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C09C: TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES (treatment of materials specially adapted to enhance their filling properties in mortars, concrete or artificial stone C04B14/00, C04B18/00, C04B20/00); PREPARATION OF CARBON BLACK {; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS}
- C09K: MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C01P: INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS

## Abstract

This invention provides core shell silica particles, wherein each core shell silica particle comprises a silica core, and a surface of the silica core etched with group I metal silicate. These core shell silica particles have high surface charge density and anti-bacterial activity. Also provided are compositions comprising core shell silica particles, process of making the core shell silica particles and methods of reducing or inhibiting bacterial activity by administering the core shell silica particles or compositions thereof.

## Claims

### Claim 1

A process for making an oral care composition comprising:
providing silica particles in water;
providing a base, wherein the base comprises a Group I metal ion;
admixing the silica particles in water with the base until the conductivity has decreased by at least 2 mS/cm as compared to the original conductivity;
combining the particles thus formed with an orally acceptable carrier to form an oral care composition.

### Claim 2 (depends on 1)

The process according to claim 1, wherein the base is in solid or aqueous form, and the base is selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, trisodium phosphate, disodium phosphate, potassium phosphate, dipotassium phosphate, tetrasodium pyrophosphate, and tetrapotassium pyrophosphate.

### Claim 3 (depends on 1)

The process of claim 1, wherein the silica particles are selected from the group consisting of a precipitated silica, a fumed silica and a fused silica.

### Claim 4 (depends on 2)

The process according to claim 2, wherein the base is 50% aqueous sodium hydroxide solution and the admixing step is carried out at a temperature of from 70 to 90° C.

### Claim 5 (depends on 2)

The process according to claim 2, wherein the base is potassium hydroxide and the admixing step is carried out at room temperature.

### Claim 6 (depends on 1)

The process according to claim 1, wherein the formation of the particles thus formed is complete after a time period of 2 hrs.

### Claim 7 (depends on 1)

The process according to claim 1, wherein the weight ratio for the amount of the base to the amount of silica particles is from 1:1 to 1:20.

### Claim 8 (depends on 7)

The process according to claim 7, wherein the weight ratio for the amount of the base to the amount of silica particles is from 1:1 to 1:6.

### Claim 9 (depends on 1)

The process according to claim 1, wherein the base is 50% aqueous sodium hydroxide solution.

### Claim 10 (depends on 1)

The process according to claim 1, wherein the admixing occurs in the presence of a humectant, wherein the weight ratio for the amount of the humectant to water ranges from 4:1 to 1:4.

### Claim 11 (depends on 1)

The process according to claim 1, wherein the admixing occurs until the conductivity has decreased by at least 5 mS/cm as compared with the original conductivity.

### Claim 12 (depends on 1)

The process of claim 1, further comprising applying the oral care composition to the oral surfaces of a patient in need thereof.

### Claim 13 (depends on 1)

The process of claim 1, further comprising applying the oral care composition to the surface of a removable oral device.

### Claim 14 (depends on 13)

The process of claim 13, wherein the removable oral device is selected from the group consisting of a denture, tray, mouthpiece, orthodontial braces and a retainer.