# US 10,369,088 B2 · Photosensitizer based microspheres > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,369,088 B2 - Document ID: US10369088B2 - Status: Granted - Kind: B2 - Application number: 15/459,517 - Filed: 2017-03-15 - Published: 2018-09-20 - Granted: 2019-08-06 - Earliest claimed: 2017-03-15 - Assignees: International Business Machines Corporation - Applicants: International Business Machines Corporation - Inventors: Scott B. King; Brandon M. Kobilka; Joseph Kuczynski; Jacob T. Porter; Jason T. Wertz - Web page: https://patentgrep.com/patent/US10369088B2 ## CPC - A61K 8/11: Encapsulated compositions - A61K 8/025: {Explicitly spheroidal or spherical shape} - A61K 8/35: Ketones, e.g. benzophenone - A61K 8/37: Esters of carboxylic acids - A61K 8/40: containing nitrogen (quinones containing nitrogen A61K8/355) - A61K 8/731: {Cellulose; Quaternized cellulose derivatives} - A61K 8/8152: {Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers} - A61K 8/85: Polyesters - A61K 8/86: Polyethers - A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations - A61K 2800/412: Microsized, i.e. having sizes between 0.1 and 100 microns - A61K 2800/413: Nanosized, i.e. having sizes below 100 nm - A61K 2800/56: Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract An encapsulated sunscreen composition that includes a polymeric shell material having a substantially spherical geometry. The shell material is a polymeric composition that includes a photosensitizer chemically bound to the polymeric composition. The polymeric shell material has a minimum diameter of 100 nm. ## Claims ### Claim 1 An encapsulated photosensitizer composition comprising: a shell material having a substantially spherical geometry, wherein the shell material comprises a polymeric composition comprising a photosensitizer chemically-bound to the polymeric composition. ### Claim 2 (depends on 1) The encapsulate photosensitizer composition of claim 1, wherein the shell material has a minimum diameter of 100 nm. ### Claim 3 (depends on 1) The encapsulate photosensitizer composition of claim 1, wherein the photosensitizer comprises a polyhydroxylated composition selected from the group consisting of oxybenzone, avobenzone, octisalate, octocrylene, homosalate, octinoxate, and combinations thereof. ### Claim 4 (depends on 1) The encapsulate photosensitizer composition of claim 1, wherein the polymeric composition is a derivative of a polymer selected from the group consisting of ethylene-(methyl acrylate) (EMA) , polyacrylate, a polymethacrylate, a cellulose ether or ester, and a combination thereof. ### Claim 5 (depends on 1) The encapsulate photosensitizer composition of claim 1, wherein the shell material of the polymeric composition is entirely encapsulating a core material of an oil or fragrance. ### Claim 6 (depends on 1) The encapsulate photosensitizer composition of claim 1, wherein the core material is selected from the group consisting of anti-microbial compositions, anti-inflamatory compositions, odorants, oils, anti-irritant compositions, anti-aging compositions, anti-acne compositions, antibiotics and combinations thereof. ### Claim 7 (depends on 1) The encapsulate photosensitizer composition of claim 1, wherein the shell material has a thickness of 100 nm or greater. ### Claim 8 A lotion comprising: an active ingredient comprising an encapsulated photosensitizer composition of a shell material having a substantially spherical geometry, wherein the shell material comprises a polymeric composition comprising a photosensitizer chemically bound to the polymeric composition; and a lotion liquid base containing the active ingredient mixed therein. ### Claim 9 (depends on 8) The lotion of claim 8, wherein the shell material has a minimum diameter of 100 nm, and the shell material has a thickness of 100 nm or greater. ### Claim 10 (depends on 8) The lotion of claim 8, wherein the photosensitizer comprises a polyhydroxylated composition selected from the group consisting of oxybenzone, avobenzone, octisalate, octocrylene, homosalate, octinoxate, and combinations thereof. ### Claim 11 (depends on 8) The lotion of claim 8, wherein the polymeric composition is a derivative of a polymer selected from the group consisting of ethylene-(methyl acrylate) (EMA) , polyacrylate, a polymethacrylate, a cellulose ether or ester, and a combination thereof. ### Claim 12 (depends on 8) The lotion of claim 8, wherein the shell material of the polymeric composition is entirely encapsulating a core material of an oil or fragrance. ### Claim 13 (depends on 8) The lotion of claim 8, wherein the core material is selected from the group consisting of anti-microbial compositions, anti-inflamatory compositions, odorants, oils, anti- irritant compositions, anti-aging compositions, anti-acne compositions, antibiotics and combinations thereof. ### Claim 14 A method of forming a photosensitizer composition comprising: forming a polyhydroxylate of a photosensitizer selected from the group consisting of oxybenzone, avobenzone, octisalate, octocrylene, homosalate, octinoxate and combinations thereof; creating an aqueous solution including a polymeric wall forming material; mixing the aqueous solution including the polyhydroxylate of the photosensitizer with the aqueous solution in combination with a polymeric shell forming material provide an emulsion; and adding a core agent to the emulsion, wherein wall forming material encapsulates the core agent to provide a shell material having a substantially spherical geometry with a polymeric composition having a chemically bound photosensitizer provided by said polyhdroxylate. ### Claim 15 (depends on 14) The method of claim 14, wherein the shell material has a minimum diameter of 100 nm, and the shell material has a thickness of 100 nm or greater. ### Claim 16 (depends on 15) The method of claim 15 further comprising mechanical mixing of said emulsion. ### Claim 17 (depends on 14) The method of claim 14, further comprising adjusting the PH to initiate encapsulation of the core material with the polymeric wall forming material. ### Claim 18 (depends on 14) The method of claim 14 further comprising adding formaldehyde to the emulsion to cure the shell material. ### Claim 19 (depends on 14) The method of claim 14, wherein the polymeric wall forming material is a polymer selected from the group consisting of ethylene-(methyl acrylate) (EMA) , polyacrylate, a polymethacrylate, a cellulose ether or ester, and a combination thereof. ### Claim 20 (depends on 14) The method of claim 14, wherein the polymeric shell forming material comprises at least one of urea (CH4N2O), ammonia chloride (NH4C1), and resorcinol.