# US 10,368,995 B2 · Methods for carbonate surface coating and related bone void filler compositions

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- Number: US 10,368,995 B2
- Document ID: US10368995B2
- Status: Granted
- Kind: B2
- Application number: 15/812,847
- Filed: 2017-11-14
- Published: 2018-05-17
- Granted: 2019-08-06
- Earliest claimed: 2016-11-14
- Assignees: CaP Biomaterials, LLC
- Applicants: CaP Biomaterials, LLC
- Inventors: Lawrence A. Shimp
- Web page: https://patentgrep.com/patent/US10368995B2

## CPC

- A61F 2/30767: {Special external or bone-contacting surface, e.g. coating for improving bone ingrowth}
- A61L 27/24: Collagen
- A61L 27/306: {Other specific inorganic materials not covered by A61L27/303 - A61L27/32}
- A61L 27/32: Phosphorus-containing materials, e.g. apatite
- A61L 27/3608: {Bone, e.g. demineralised bone matrix [DBM], bone powder}
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 31/005: {Ingredients of undetermined constitution or reaction products thereof}
- A61L 31/044: {Collagen}
- A61L 31/088: {Other specific inorganic materials not covered by A61L31/084 or A61L31/086}
- A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 31/146: {Porous materials, e.g. foams or sponges}
- A61F 2002/2835: {Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 2420/02: Methods for coating medical devices
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Bone void filler compositions and methods for preparation to provide substrates with carbonate surface coatings to promote bone growth.

## Claims

### Claim 1

A method of preparing discrete calcium carbonate particles on a substrate surface, said method comprising:
providing a carbonatable calcium precursor component and applying said precursor component to a bone void filler substrate; and
contacting said substrate with a carbon dioxide source in the presence of water to convert at least a portion of said applied carbonatable calcium precursor component to calcium carbonate and provide discrete calcium carbonate particles on said substrate.

### Claim 2 (depends on 1)

The method of claim 1 wherein said precursor component is selected from calcium chloride, calcium oxide and calcium acetate.

### Claim 3 (depends on 1)

The method of claim 1 wherein said carbon dioxide source is selected from gaseous carbon dioxide, liquid supercritical carbon dioxide and sodium carbonate.

### Claim 4 (depends on 1)

The method of claim 1 wherein said carbonatable calcium precursor component is treated with an alkali metal hydroxide to provide calcium hydroxide.

### Claim 5 (depends on 4)

The method of claim 4 wherein said treatment is with sodium hydroxide.

### Claim 6 (depends on 1)

The method of claim 1 wherein said carbonatable calcium precursor component is provided as an aqueous solution thereof, and application of said carbonatable calcium precursor component is selected from dipping, soaking and spraying said substrate therewith.

### Claim 7 (depends on 1)

The method of claim 1 wherein the presence of water is selected from atmospheric water vapor about said substrate and water applied to said substrate.

### Claim 8 (depends on 1)

The method of claim 1 wherein said bone void filler substrate comprises a material selected from calcium salts, collagen, natural mammalian bone, polymers, metals and combinations thereof.

### Claim 9 (depends on 1)

The method of claim 1 wherein said substrate is applied to a mammalian bone void.

### Claim 10

A method of preparing a calcium carbonate surface coating, said method comprising:
providing a carbonatable calcium precursor component selected from calcium chloride, calcium oxide and calcium acetate, and applying said precursor component to a bone void filler substrate; and
contacting said substrate with a carbon dioxide source, optionally in the presence of water, to convert at least a portion of said applied carbonatable calcium precursor component to calcium carbonate and provide a coating of discrete, dispersed calcium carbonate particles on said substrate.

### Claim 11 (depends on 10)

The method of claim 10 wherein said carbon dioxide source is selected from gaseous carbon dioxide, liquid supercritical carbon dioxide and sodium carbonate.

### Claim 12 (depends on 10)

The method of claim 10 wherein said carbonatable calcium precursor component is treated with an alkali metal hydroxide to provide calcium hydroxide.

### Claim 13 (depends on 12)

The method of claim 12 wherein said treatment is with sodium hydroxide.

### Claim 14 (depends on 10)

The method of claim 10 wherein said carbonatable calcium precursor component is provided as an aqueous solution thereof, and application of said carbonatable calcium precursor component is selected from dipping, soaking and spraying said substrate therewith.

### Claim 15 (depends on 10)

The method of claim 10 wherein the presence of water is selected from atmospheric water vapor about said substrate and water applied to said substrate.

### Claim 16 (depends on 1)

The method of claim 1 wherein said bone void filler substrate comprises a material selected from calcium salts, collagen, natural mammalian bone, polymers, metals and combinations thereof.

### Claim 17 (depends on 10)

The method of claim 10 wherein said substrate is applied to a mammalian bone void.