# US 10,368,993 B2 · Shape-memory-actuated materials for accelerated healing of orthopedic injuries

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- Number: US 10,368,993 B2
- Document ID: US10368993B2
- Status: Granted
- Kind: B2
- Application number: 15/648,721
- Filed: 2017-07-13
- Published: 2017-11-02
- Granted: 2019-08-06
- Earliest claimed: 2013-06-20
- Assignees: Syracuse University
- Applicants: James Henderson; Patrick T. Mather
- Inventors: James Henderson; Patrick T. Mather
- Web page: https://patentgrep.com/patent/US10368993B2

## CPC

- A61F 2/2846: {Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects (nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006)}
- A61F 2/28: Bones
- A61L 27/14: Macromolecular materials
- A61L 27/16: obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/3847: {Bones}
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61F 2002/2817: {Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]}
- A61F 2002/2839: {Bone plugs or bone graft dowels}
- A61F 2002/285: {Fixation appliances for attaching bone substitute support means to underlying bone}
- A61F 2002/30092: {using shape memory or superelastic materials, e.g. nitinol}
- A61F 2210/0014: using shape memory or superelastic materials, e.g. nitinol
- A61L 2400/16: Materials with shape-memory or superelastic properties
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A three component system for repairing critically sized bone defects having a first shape memory polymer (SMP) component formed as a scaffold that fills the defects, a second SMP component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third SMP component formed as a two-dimensional cell culture substrate for engineering periosteal grafts.

## Claims

### Claim 1

A method of repairing a bone defect, comprising the steps of:
positioning a porous foam scaffold comprised of a shape memory polymer configured for expansion in response to a stimulus within said bone defect, wherein said porous foam scaffold has a pore size of 200 to 500 micrometers and a porosity of 79 percent plus or minus five percent;
applying a stimulus to said scaffold to cause said porous foam scaffold to expand into said bone defect.

### Claim 2 (depends on 1)

The method of claim 1, wherein said porous foam scaffold comprises a polymer selected from the group consisting of poly(tert-butyl acrylate/butyl acrylate), poly-DL-lactide, and poly-DL-lactide/polyhedral oligomeric silsesquioxane.

### Claim 3 (depends on 1)

The method of claim 1, further comprising the steps of:
positioning a sleeve comprised of a second shape memory polymer that is configured for radial contraction in response to a second stimulus around said bone defect and said porous foam scaffold;
applying said second stimulus to contract said sleeve around said bone defect and said porous foam scaffold.

### Claim 4 (depends on 3)

The method of claim 3, wherein said sleeve comprises a thermoplastic polyurethane.

### Claim 5 (depends on 4)

The method of claim 4, said sleeve includes semi-crystalline polyester fibers.

### Claim 6 (depends on 5)

The method of claim 5, wherein the semi-crystalline polyester fibers comprise poly(L-lactic acid).