# US 10,368,992 B2 · Resorbable and biocompatible graft in PGA for implant following excision of the IPP plaque

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- Number: US 10,368,992 B2
- Document ID: US10368992B2
- Status: Granted
- Kind: B2
- Application number: 15/547,456
- Filed: 2016-01-28
- Published: 2018-01-11
- Granted: 2019-08-06
- Earliest claimed: 2015-01-30
- Applicants: Antonio Sambusseti
- Inventors: Antonio Sambusseti
- Web page: https://patentgrep.com/patent/US10368992B2

## CPC

- A61F 2/26: Penis implants
- A61F 2/0063: {Implantable repair or support meshes, e.g. hernia meshes}
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C08L 67/04: Polyesters derived from hydroxycarboxylic acids, e.g. lactones (C08L67/06 takes precedence)
- A61F 2005/411: {Penile supports}
- A61F 2210/0004: bioabsorbable
- A61L 2430/34: for soft tissue reconstruction
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)

## Abstract

Disclosed is a graft for implant after excision of the IPP (induratio penis plastica) plaque due to Peyronie's disease. The graft is formed by a loom woven fabric, with low porosity, deriving from a monofilament or multifilament yarn of fibers of resorbable polymer in PGA (polyglycolide).

## Claims

### Claim 1

Bioabsorbable graft (1) for use in permanent implant after excision of a IPP (induratio penis plastica) plaque due to Peyronie's disease, consisting of a fabric (2) having a low porosity equal to or lower than 50%,
said fabric deriving from a yarn of fibres made of a resorbable polymer of PGA (polyglycolide), having a thickness lower than 600 microns,
said graft (1) having a planar flat form, the graft being a loom woven fabric made without reinforcements and/or support structure,
said graft (1) in woven fabric is inherently capable without further modification of being impermeable to arteria blood and of being implanted without any deposition of tissue cells on its surface.

### Claim 2 (depends on 1)

Graft (1) according to claim 1 wherein said woven fabric (2) in PGA is formed with a multifilament or with a monofilament yarn having a basis weight lower than 120 deniers.

### Claim 3 (depends on 2)

Graft (1) according to claim 2 wherein a monofilament of PGA is used, and the fabric (2) has a basis weight lower than 240 deniers and the monofilament of PGA has a denier count lower than 120 deniers.

### Claim 4 (depends on 2)

Graft (1) according to claim 2 wherein a multifilament yarn in PGA is used, and it is a multifilament yarn of 75 deniers/30 filaments.

### Claim 5 (depends on 2)

Graft (1) according to claim 2, having a rectangular or square form in plan view.

### Claim 6 (depends on 1)

Graft (1) according to claim 1 wherein a monofilament of PGA is used, and the fabric (2) has a basis weight lower than 240 deniers and the monofilament of PGA has a denier count lower than 120 deniers.

### Claim 7 (depends on 6)

Graft (1) according to claim 6 wherein a multifilament yarn in PGA is used, and it is a multifilament yarn of 75 deniers/30 filaments.

### Claim 8 (depends on 6)

Graft (1) according to claim 6, having a rectangular or square form in plan view.

### Claim 9 (depends on 1)

Graft (1) according to claim 1 wherein a multifilament yarn in PGA is used, and it is a multifilament yarn of 75 deniers/30 filaments.

### Claim 10 (depends on 9)

Graft (1) according to claim 9, having a rectangular or square form in plan view.

### Claim 11 (depends on 1)

Graft (1) according to claim 1, having a rectangular or square form in plan view.

### Claim 12 (depends on 11)

The graft of claim 11, wherein the graft is in a rectangular form having dimensions of 5 cm×10 cm.

### Claim 13 (depends on 1)

Graft (1) according to claim 1 wherein said woven fabric (2) comprises a plain weave.

### Claim 14 (depends on 1)

Graft (1) according to claim 1 wherein said woven fabric (2) has
a warp density—ends per cm or EPC—which is comprised between 50-100 ends/cm, and
a weft density—counts per cm or CPC—which is comprised within a range of 30-70 counts/cm.

### Claim 15 (depends on 1)

Graft (1) according to claim 1 wherein the porosity of said woven fabric (2) is within the range from 5% to 50%.