# US 10,368,938 B2 · Margin extension device and method

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- Number: US 10,368,938 B2
- Document ID: US10368938B2
- Status: Granted
- Kind: B2
- Application number: 14/877,261
- Filed: 2015-10-07
- Published: 2016-04-07
- Granted: 2019-08-06
- Earliest claimed: 2014-10-07
- Assignees: City of Hope
- Applicants: City of Hope
- Inventors: Gagandeep Singh; Jonathan Kessler
- Web page: https://patentgrep.com/patent/US10368938B2

## CPC

- A61B 18/1402: {Probes for open surgery}
- A61B 2018/00077: {high, i.e. electrically conducting}
- A61B 2018/00327: {Ear, nose or throat}
- A61B 2018/00488: {Esophagus}
- A61B 2018/00494: {Stomach, intestines or bowel}
- A61B 2018/005: {Rectum}
- A61B 2018/00541: {Lung or bronchi}
- A61B 2018/00559: {Female reproductive organs}
- A61B 2018/00577: {Ablation}
- A61B 2018/00613: {Irreversible electroporation}
- A61B 2018/143: {multiple needles}
- A61B 2018/1467: {using more than two electrodes on a single probe}
- A61N 1/327: {for enhancing the absorption properties of tissue, e.g. by electroporation}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A margin extension device and method are disclosed herein. The margin extension device can be used for ablating one or several cancer cells and can include a contact member and a plurality of electrodes. The contact member can be electrically conductive, and can electrically connect the electrodes. The margin extension device can further include one or several leads that connect the electrodes of the margin extension device to a treatment controller. The treatment controller can include a pulse generator that can generate one or several electrical pulses that generate one or several electrical fields in tissue proximate to the margin extension device.

## Claims

### Claim 1

A method of generating a negative margin around an excised tumor, the method comprising:
excising a tumor from a living tissue, wherein the excision of the tumor does not create a negative margin at a portion of the tissue surrounding the tumor;
applying a surgical margin extender to the portion of the tissue surrounding the tumor that does not have a negative margin, wherein the margin extender comprises:
an anode;
a cathode; and
a contact member, wherein the contact member comprises a conductive material that electrically connects the anode and the cathode; and wherein the contact member electrically connects the anode and cathode at a distance such that the anode and the cathode can electroporate a cancer cell, wherein the contact member has an electrical conductivity that matches a conductivity of the tissue surrounding the tumor; and
wherein applying the surgical margin extender includes rolling the contact member to form a cylindrical insert and inserting the cylindrical insert into a void defined by the tissue;
applying an electrical current to the contact member via the anode and cathode, wherein the application of the electrical current to the contact member via the anode and the cathode electroporates the cancer cell in the portion of the tissue to which the margin extender is applied.

### Claim 2 (depends on 1)

The method of claim 1, wherein applying the margin extender to the portion of the tissue surrounding the tumor that does not have a negative margin comprises at least partially filling a void left by the excised tumor with the margin extender.

### Claim 3 (depends on 2)

The method of claim 2, wherein filling the void left by the excised tumor with the margin extender comprises:
inserting the anode and the cathode into the void; and
connecting the anode and cathode with the contact member.

### Claim 4 (depends on 3)

The method of claim 3, wherein the anode and cathode are inserted into the void after being connected by the contact member.

### Claim 5 (depends on 3)

The method of claim 3, wherein the anode and cathode are connected by the contact member after being inserted into the void.