# US 10,368,874 B2 · Embolic compositions

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- Number: US 10,368,874 B2
- Document ID: US10368874B2
- Status: Granted
- Kind: B2
- Application number: 15/687,263
- Filed: 2017-08-25
- Published: 2018-03-01
- Granted: 2019-08-06
- Earliest claimed: 2016-08-26
- Assignees: MicroVention, Inc.
- Applicants: MicroVention, Inc.
- Inventors: Aaron Baldwin; Ami Mehta; Jonathan Lam
- Web page: https://patentgrep.com/patent/US10368874B2

## CPC

- A61B 17/12181: {formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices}
- A61B 17/12186: {liquid materials adapted to be injected}
- A61K 31/785: Polymers containing nitrogen
- A61K 49/0438: {Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol}
- A61K 49/0442: {Polymeric X-ray contrast-enhancing agent comprising a halogenated group}
- C08F 20/26: Esters containing oxygen in addition to the carboxy oxygen
- A61B 2017/00938: {hydrophobic}
- A61B 2017/00942: {hydrophilic}
- A61B 2090/3933: {Liquid markers}
- A61B 2090/3966: {Radiopaque markers visible in an X-ray image}
- C08L 33/14: of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)

## Abstract

Described herein are compositions comprising, a polymer; a non-physiological solution; and a visualization agent; wherein the polymer is soluble in the non-physiological solution and insoluble at physiological conditions. Methods of preparing the compositions are disclosed as well as methods of using these compositions to treat vascular conditions.

## Claims

### Claim 1

A composition comprising:
1) a biocompatible polymer formed from:
a) hydroxyethylmethacrylate monomers, or vinyl alcohol monomers, or hydroxyethylmethacrylate monomers and vinyl alcohol monomers; and
b) aromatic amine monomers;
2) a solvent; and
3) a visualization agent;
wherein the biocompatible polymer is soluble in the solvent and insoluble at physiological conditions; and
wherein the visualization agent is integrated into or associated with the biocompatible polymer, and the visualization agent is triiodophenol-lactide-glycolide (TIP).

### Claim 2 (depends on 1)

The composition of claim 1, wherein the physiological conditions include contact with a physiological fluid including blood, urine, saliva, mucous, vaginal fluid, seminal fluid, cerebral spinal fluid, sweat, plasma, bile, stomach acid, intestinal fluids, or a combination thereof.

### Claim 3 (depends on 2)

The composition of claim 2, wherein the physiological fluid has a pH of about 7.0.

### Claim 4 (depends on 2)

The composition of claim 2, wherein the physiological fluid has a pH of between about 7.0 and about 7.8.

### Claim 5 (depends on 1)

The composition of claim 1, wherein the solvent is a water miscible organic solvent.

### Claim 6 (depends on 1)

The composition of claim 1, wherein the aromatic amine monomer includes an amino group which is about 90% positively charged at a pH of 5 and about 10% positively charged at a pH of 7.

### Claim 7 (depends on 1)

The composition of claim 1, wherein the biocompatible polymer comprises hydroxyethylmethacrylate, polyvinyl pyridine (PVP), 1-vinylimidazole, 4-vinylpyridine, or a combination thereof.

### Claim 8 (depends on 1)

The composition of claim 1, wherein the biocompatible polymer includes about 60% w/w HEMA and the visualization agent includes about 40% w/w TIP.

### Claim 9 (depends on 1)

The composition of claim 1, wherein the biocompatible polymer includes about 15% w/w HEMA and the visualization agent includes about 85% w/w TIP.

### Claim 10 (depends on 1)

The composition of claim 1, wherein the solvent is water or a co-solvent of water and dimethyl sulfoxide (DMSO).

### Claim 11 (depends on 1)

The composition of claim 1, wherein the biocompatible polymer is formed from hydroxyethylmethacrylate monomers and aromatic amine monomers.