# US 10,368,843 B2 · Ultrasonic shear wave imaging with focused scanline beamforming

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- Number: US 10,368,843 B2
- Document ID: US10368843B2
- Status: Granted
- Kind: B2
- Application number: 13/511,307
- Filed: 2010-11-15
- Published: 2013-05-23
- Granted: 2019-08-06
- Earliest claimed: 2009-11-25
- Assignees: Koninklijke Philips N.V.
- Applicants: Roy Beck Peterson; Yan Shi; Hua Xie; Jean-Luc Robert; Vijay Shamdasani; Robert Randall Entrekin; Anna Teresa Ferandez
- Inventors: Roy Beck Peterson; Yan Shi; Hua Xie; Jean-Luc Robert; Vijay Shamdasani; Robert Randall Entrekin; Anna Teresa Ferandez
- Web page: https://patentgrep.com/patent/US10368843B2

## CPC

- A61B 8/485: {involving measuring strain or elastic properties}
- A61B 5/0048: {Detecting, measuring or recording by applying mechanical forces or stimuli (A61B5/021, A61B5/4884 and A61B9/00 take precedence)}
- A61B 8/08: Clinical applications (A61B8/02, A61B8/04, A61B8/06 take precedence)
- A61B 8/14: Echotomography
- A61B 8/463: {characterised by displaying multiple images or images and diagnostic data on one display}
- A61B 8/5223: {for extracting a diagnostic or physiological parameter from medical diagnostic data (for algorithms to analyse biomedical images G06T7/0012)}
- G01S 7/52022: {using a sequence of pulses, at least one pulse manipulating the transmissivity or reflexivity of the medium}
- G01S 7/52042: {determining elastic properties of the propagation medium or of the reflective target (diagnostic techniques involving the measurement of strain A61B8/485)}
- G01S 7/52071: {Multicolour displays; using colour coding; Optimising colour or information content in displays, e.g. parametric imaging}
- G01S 7/52085: {Details related to the ultrasound signal acquisition, e.g. scan sequences (control of medical diagnostic ultrasound devices A61B8/54)}
- G01S 7/52095: {using multiline receive beamforming}
- G01S 15/8915: {using a transducer array}
- A61B 8/085: {for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules}
- G01S 15/8984: {Measuring the velocity vector}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01S: RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES

## Abstract

An ultrasonic diagnostic imaging system produces an image of shear wave velocities by transmitting push pulses to generate shear waves. A plurality of tracking lines are transmitted and echoes received by a focusing beamformer adjacent to the location of the push pulses. The tracking lines are sampled in a time-interleaved manner. The echo data acquired along each tracking line is processed to determine the time of peak tissue displacement caused by the shear waves at points along the tracking line, and the times of peaks at adjacent tracking lines compared to compute a local shear wave velocity. The resultant map of shear wave velocity values is color-coded and displayed over an anatomical image of the region of interest.

## Claims

### Claim 1

An ultrasonic diagnostic imaging system for shear wave analysis comprising:
an ultrasound probe comprising a two-dimensional array;
a beamformer configured to control the following:
transmit, from the ultrasound probe, push pulses along a plurality of push pulse vectors to generate a corresponding plurality of shear wave fronts each having a respective velocity, wherein the plurality of push pulse vectors are spatially interleaved in a lateral direction and the push pulses are differently sequenced in a depth direction along different ones of the plurality of push pulse vectors;
transmit, from the ultrasound probe, tracking pulses along laterally separated tracking lines in a region adjacent to the plurality of push pulse vectors, wherein the tracking pulses are transmitted along the laterally separated tracking lines in a time-interleaved sequence such that the laterally separated tracking lines may be sampled a plurality of times after the push pulses are transmitted; and
receive, from the ultrasound probe, echo signals from points along the laterally separated tracking lines to sample the laterally separated tracking lines the plurality of times after the push pulses are transmitted; and
a processor configured to:
store tracking line echo data generated from the received echo signals as the corresponding plurality of shear wave fronts pass through the laterally separated tracking lines;
in response to the tracking line echo data, detect motion due to the shear wave fronts passing through the tracking lines, wherein detecting motion comprises successively sampling the tracking line echo data;
measure the respective velocities of the corresponding plurality of shear wave fronts passing through the laterally separated tracking lines; and
display results of measuring the respective velocities of the corresponding plurality of shear wave fronts.

### Claim 2 (depends on 1)

The ultrasonic diagnostic imaging system of claim 1, wherein the detecting motion comprises detecting tissue displacement caused by the corresponding plurality of shear wave fronts.

### Claim 3 (depends on 2)

The ultrasonic diagnostic imaging system of claim 2, wherein the detecting motion comprises cross-correlating the tracking line echo data to detect motion of wavefront peaks of the corresponding plurality of shear wave fronts.

### Claim 4 (depends on 3)

The ultrasonic diagnostic imaging system of claim 3, wherein measuring the respective velocities comprises comparing times of occurrence of two displacement peaks in the corresponding plurality of shear wave fronts.

### Claim 5 (depends on 1)

The ultrasonic diagnostic imaging system of claim 1, wherein the displaying comprises displaying a two dimensional image of the respective velocities of the corresponding plurality of shear wave fronts.

### Claim 6 (depends on 5)

The ultrasonic diagnostic imaging system of claim 5, wherein the respective velocities of the corresponding plurality of shear wave fronts are color-coded and overlaid on an anatomical image.

### Claim 7 (depends on 1)

The ultrasonic diagnostic imaging system of claim 1, wherein the beamformer comprises a multiline beamformer.

### Claim 8 (depends on 1)

The ultrasonic diagnostic imaging system of claim 1, wherein the detecting motion comprises detecting a time of peak tissue displacement at the points along the laterally separated tracking lines.

### Claim 9 (depends on 8)

The ultrasonic diagnostic imaging system of claim 8, wherein the detecting motion comprises detecting a plurality of displacement values by local cross correlation of the tracking line echo.

### Claim 10 (depends on 9)

The ultrasonic diagnostic imaging system of claim 9, wherein the detecting motion comprises detecting a time of peak tissue displacement by curve-fitting to the plurality of displacement values.

### Claim 11 (depends on 9)

The ultrasonic diagnostic imaging system of claim 9, wherein the detecting motion comprises detecting a time of peak tissue displacement by interpolating the plurality of displacement values.

### Claim 12 (depends on 7)

The ultrasonic diagnostic imaging system of claim 7, wherein the multiline beamformer is adapted to detect the echo signals from the plurality of laterally spaced tracking lines in response to a single tracking pulse of the tracking pulses.

### Claim 13 (depends on 1)

The ultrasonic imaging system of claim 1, wherein the push pulse vectors are spatially dithered in the lateral direction.

### Claim 14 (depends on 1)

The ultrasonic imaging system of claim 1, wherein the plurality of push pulse vectors are spatially interleaved such that a push pulse vector of the plurality of push pulse vectors is offset such that the thermal effects of the plurality of push pulse vectors are separated, such that thermal effects cannot accumulate at any one point.

### Claim 15 (depends on 1)

The ultrasonic imaging system of claim 1,
wherein the push pulses are differently sequenced in the depth direction along different ones of the plurality of push pulse vectors such that the push pulses along a first push pulse vector of the plurality of push pulse vectors are sequenced beginning at a first depth and ending at a second depth and the push pulses along a second push pulse vector of the plurality of push pulse vectors are sequenced beginning at the second depth and ending at the first depth,
wherein the second depth is deeper than the first depth.

### Claim 16

A method for operating an ultrasonic diagnostic imaging system to measure shear waves comprising:
transmitting, using an ultrasound probe comprising a two-dimensional array, at least one transmission of push pulses along each of a plurality of push pulse vectors to generate a corresponding plurality of shear wave fronts each having a respective velocity, wherein the plurality of push pulse vectors are spatially interleaved in a lateral direction and push pulses of the at least one transmission of push pulses along each of the plurality of push pulse vectors are differently sequenced in a depth direction along different ones of the plurality of push pulse vectors;
transmitting, using the ultrasound probe, a plurality of focused tracking pulses along a plurality of laterally separated tracking lines adjacent to the plurality of push pulse vectors, wherein transmitting the plurality of focused tracking pulses comprises transmitting the plurality of focused tracking pulses along each of the plurality of laterally separated tracking lines in a time-interleaved manner such that the plurality of laterally separated tracking lines may be sampled a plurality of times after the push pulses have been transmitted;
receiving, using the ultrasound probe, focused echo signals in response to the transmission of the plurality of focused tracking pulses to sample the plurality of laterally separated tracking lines the plurality of times after the at least one transmission of push pulses has been transmitted;
processing, using an ultrasound system, the echo signals to determine shear wave velocity values at a plurality of points in two or three dimensions in a region of interest; and
displaying on a display a two or three dimensional image of the respective velocities of the corresponding plurality of shear wave fronts at the plurality of points.

### Claim 17 (depends on 16)

The method of claim 16, wherein receiving focused echo signals further comprises receiving the focused echo signals from along the laterally spaced tracking lines in response to each transmission of the plurality of tracking pulses.

### Claim 18 (depends on 16)

The method of claim 16, wherein processing further comprises processing the echo signals to determine tissue motion resulting from the corresponding plurality of shear wave fronts.

### Claim 19 (depends on 18)

The method of claim 18, wherein processing further comprises processing the echo signals to determine tissue displacement along the plurality of points in two or three dimensions in the region of interest.