# US 10,368,832 B2 · Lung tissue identification in anatomically intelligent echocardiography > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,368,832 B2 - Document ID: US10368832B2 - Status: Granted - Kind: B2 - Application number: 14/900,788 - Filed: 2014-06-18 - Published: 2016-06-02 - Granted: 2019-08-06 - Earliest claimed: 2013-06-28 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Sheng-Wen Huang; Emil George Radulescu; Ramon Quido Erkamp - Web page: https://patentgrep.com/patent/US10368832B2 ## CPC - A61B 8/0858: {involving measuring tissue layers, e.g. skin, interfaces} - A61B 8/085: {for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules} - A61B 8/14: Echotomography - A61B 8/463: {characterised by displaying multiple images or images and diagnostic data on one display} - A61B 8/48: {Diagnostic techniques (A61B8/13 takes precedence)} - A61B 8/5215: {involving processing of medical diagnostic data} - A61B 8/5223: {for extracting a diagnostic or physiological parameter from medical diagnostic data (for algorithms to analyse biomedical images G06T7/0012)} - G01S 7/52036: {using analysis of echo signal for target characterisation} - G01S 7/52071: {Multicolour displays; using colour coding; Optimising colour or information content in displays, e.g. parametric imaging} - G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems - G01S 7/52038: {involving non-linear properties of the propagation medium or of the reflective target} - G01S 15/8925: {the array being a two-dimensional transducer configuration, i.e. matrix or orthogonal linear arrays} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01S: RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract Issuance of ultrasound pulses to a volume and receiving echo data is followed by estimating, based on the received data, center frequency subvolume-by-subvolume. Distinguishing between heart and lung tissue occurs based on a result of the estimating, and may include automatically identifying a spatial boundary (332) between the heart and lung tissue (324, 328), or a user display of center frequencies that allows for visual distinguishing. The issuance can include issuing, ray line by ray line, pair-wise identical, and/or pair-wise mutually inverted, ultrasound pulses. Center frequency calculations may be made for incremental sampling locations of respective imaging depth along each of the A-lines generated from echo data of the rays. The distinguishing might entail averaging center frequencies for locations along an A-line, and applying a central frequency threshold to the average. The leftmost of the qualifying A-lines, i.e., that meet the threshold, may determine the spatial boundary in the current imaging plane. ## Claims ### Claim 1 An apparatus comprising: an ultrasound interface module configured for issuing ultrasound pulses to a volume and for receiving echo data; and a center frequency determination module configured to estimate a center frequency of the received echo data at each of a plurality of locations in the volume; and a tissue discrimination module configured, for each of the plurality of locations, to assign a given location as corresponding to lung tissue, heart tissue, or a spatial boundary between said heart and lung tissue based upon a determination that the estimated center frequency for the given location is higher or lower than, respectively, a given threshold. ### Claim 2 (depends on 1) The apparatus of claim 1, further comprising a matrix probe, said boundary having a three-dimensional path, said apparatus further comprising a display, said apparatus configured for displaying, via said display, said path multi-dimensionally for a given position of said probe. ### Claim 3 (depends on 2) The apparatus of claim 2, said displaying using a representation that shows how lateral and elevational components of said path jointly vary along said path. ### Claim 4 (depends on 1) The apparatus of claim 1, further comprising: a display; and an ultrasound imaging probe for said issuing and said receiving, said apparatus configured for presenting, via said display, the identified boundary to provide user guidance, while imaging, for moving said probe to achieve a target view. ### Claim 5 (depends on 1) The apparatus of claim 1, wherein the identification of the spatial boundary comprises selecting from among A-lines based on the threshold. ### Claim 6 (depends on 5) The apparatus of claim 5, said selecting comprising applying the threshold at each of the plurality of locations along a given one of said A-lines. ### Claim 7 (depends on 5) The apparatus of claim 5, wherein the identification of the spatial boundary comprises qualifying candidate A-lines for the selecting, the selected A-line defining the spatial boundary between said heart and lung tissue. ### Claim 8 (depends on 7) The apparatus of claim 7, said qualifying of a candidate A-line relying on center frequency data of said candidate A-line to the exclusion of center frequency data of the other candidate A-lines. ### Claim 9 (depends on 1) The apparatus of claim 1, said identification of the spatial boundary comprising averaging center frequencies for locations along an A-line, and applying a central frequency threshold to the average. ### Claim 10 (depends on 9) The apparatus of claim 9, configured for iteratively performing said averaging, and respectively said applying, in correspondence with different positions along said A-line. ### Claim 11 (depends on 1) The apparatus of claim 1, said issuing comprising issuing, ray line by ray line, pair-wise identical, and/or pair-wise mutually inverted, ultrasound pulses. ### Claim 12 (depends on 11) The apparatus of claim 11, said ultrasound module configured for, in case of issuing pair-wise identical pulses, computing a difference between an echo of one of the pair and an echo of the other of the pair. ### Claim 13 (depends on 11) The apparatus of claim 11, said ultrasound module configured for, in case of inverted pulses, ultrasound pulse inversion by which an inverted copy of a just preceding pulse is issued and summing an echo of said copy with an echo of said just preceding pulse. ### Claim 14 (depends on 1) The apparatus of claim 1, said estimating being performed at each of the plurality of locations along a given A-line. ### Claim 15 (depends on 1) The apparatus of claim 1, configured for subjecting data derived from said receiving to low pass filtering. ### Claim 16 (depends on 15) The apparatus of claim 15, configured for subjecting data derived from said receiving to high pass filtering. ### Claim 17 (depends on 16) The apparatus of claim 16, configured for combining, for said estimating, the low pass filtered data with the high pass filtered data. ### Claim 18 (depends on 17) The apparatus of claim 17, said combining comprising assigning a first weight to the low pass filtered data, assigning a second weight to the high pass filtered data, and computing a weighted average that uses the weights. ### Claim 19 (depends on 15) The apparatus of claim 15, said receiving comprising receiving pulse inversion samples, said estimating comprising computing a difference between, and a sum of, a pair of said samples and performing said low pass filtering on the difference and said high pass filtering on the sum. ### Claim 20 (depends on 15) The apparatus of claim 15, said deriving comprising computing: in case of pulse inversion, a difference between an echo from a pulse, from among said pulses, and an echo from an inversion of said pulse, to yield said data derived; and, in case of pulse subtraction, a sum of respective echoes of said pulse and a pulse identical to said pulse, to yield said data derived. ### Claim 21 (depends on 1) The apparatus of claim 1, further comprising a display and configured for displaying, on said display, a center frequency map that, for an imaging plane, spatially represents the estimated center frequencies at each of the plurality of locations. ### Claim 22 (depends on 1) The apparatus of claim 1, wherein the tissue discrimination module is configured to determine a spatially selected region of the volume and assign each of the plurality of given locations within the spatially selected region as corresponding to either lung tissue or heart tissue based upon the determination that the estimated center frequency for the given location is higher or lower than a given threshold. ### Claim 23 A computer readable medium embodying a computer program for body tissue discrimination, said program having instructions executable by a processor to perform a plurality of acts, such that from among said plurality are the acts of: issuing ultrasound pulses to a volume and for receiving echo data; and estimating, based on the received data, a center frequency of the received echo data at each of a plurality of locations in the volume; and determining, for each of the plurality of locations, that a given location corresponds to lung tissue, heart tissue, or a spatial boundary between said heart and lung tissue based on a determination that the estimated center frequency for the given location is higher or lower than a given threshold.