# US 10,368,831 B2 · Waveform enhanced reflection and margin boundary characterization for ultrasound tomography > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,368,831 B2 - Document ID: US10368831B2 - Status: Granted - Kind: B2 - Application number: 15/829,748 - Filed: 2017-12-01 - Published: 2018-06-07 - Granted: 2019-08-06 - Earliest claimed: 2016-12-02 - Assignees: Delphinus Medical Technologies, Inc. - Applicants: Delphinus Medical Technologies, Inc. - Inventors: Nebojsa Duric; Peter J. Littrup; Gursharan Singh Sandhu; Mark Krycia; Mark Sak - Web page: https://patentgrep.com/patent/US10368831B2 ## CPC - A61B 8/0825: {for diagnosis of the breast, e.g. mammography} - A61B 8/085: {for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules} - A61B 8/13: Tomography (A61B8/10, A61B8/12 take precedence) - A61B 8/15: Transmission-tomography - A61B 8/406: {using means for diagnosing suspended breasts} - A61B 8/5207: {involving processing of raw data to produce diagnostic data, e.g. for generating an image} - A61B 8/5253: {combining overlapping images, e.g. spatial compounding} - G06T 5/94: based on local image properties, e.g. for local contrast enhancement - G06T 2207/10136: 3D ultrasound image - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL ## Abstract The present invention provides improved methods and systems for generating enhanced images of a volume of tissue. In an aspect, the method comprises receiving from a transducer, a plurality of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating from the acoustic signals, a first reflection rendering that characterizes sound reflection, the first reflection rendering comprising a first distribution of reflection values across a region of the volume of tissue; generating from the acoustic signals, a sound speed rendering that characterizes sound speed, the sound speed rendering comprising a distribution of sound speed values across the region; generating from the sound speed rendering, a second reflection rendering that characterizes sound reflection, the second reflection rendering comprising a second distribution of reflection values across the region; and rendering one or more combined images, based on the first reflection rendering and the second reflection rendering. ## Claims ### Claim 1 A method for generating an enhanced image of a volume of tissue, which method is implemented by a computer comprising one or more processors and computer readable media comprising instructions, the method comprising: receiving from a transducer, a plurality of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue, wherein the transducer comprises an array of ultrasound transmitters and an array of ultrasound receivers configured to surround the volume of tissue; generating from the plurality of acoustic signals a first reflection rendering comprising a first distribution of reflection values across a region of the volume of tissue; generating from the plurality of acoustic signals a sound speed rendering comprising a distribution of sound speed values across the region of the volume of tissue; calculating a second reflection rendering from the sound speed rendering, the second reflection rendering comprising a second distribution of reflection values across the region of the volume of tissue; and generating an enhanced image of the volume of tissue by rendering one or more combined images of the first reflection rendering and the second reflection rendering. ### Claim 2 (depends on 1) The method of claim 1, wherein the tissue comprises breast tissue. ### Claim 3 (depends on 1) The method of claim 1, wherein the volume of tissue comprises a distribution of one or more of: fat tissue, parenchymal tissue, cancerous tissue, and abnormal tissue. ### Claim 4 (depends on 3) The method of claim 3, wherein the fat tissue comprises fatty parenchyma, parenchymal fat, or subcutaneous fat. ### Claim 5 (depends on 3) The method of claim 3, wherein the abnormal tissue comprises fibrocystic tissue or a fibroadenoma. ### Claim 6 (depends on 1) The method of claim 1, wherein generating the first reflection rendering comprises generating a plurality of acoustomechanical parameter slices associated with a plurality of coronal slices through the volume of tissue. ### Claim 7 (depends on 1) The method of claim 1, wherein generating the first reflection rendering comprises generating a distribution of acoustic reflection signals, wherein the acoustic reflection signals characterize a relationship between reflected intensities and emitted intensities of the acoustic waveforms, wherein the relationship is selected from the group consisting of a sum, a difference, and a ratio. ### Claim 8 (depends on 1) The method of claim 1, wherein generating the first reflection rendering comprises generating a distribution of acoustic reflection signals, wherein the acoustic reflection signals characterize a change in acoustic impedance of the volume of tissue. ### Claim 9 (depends on 1) The method of claim 1, wherein generating the first reflection rendering comprises generating a distribution of acoustic reflection signals received from a first array of transducers, the first array of transducers transmitting and receiving at a first frequency greater than a second frequency of a second array of transducers used to generate the sound speed rendering. ### Claim 10 (depends on 1) The method of claim 1, wherein generating the first reflection rendering comprises generating a distribution of acoustic reflection signals received from a first array of transducers, the first array of transducers transmitting and receiving at a first frequency less than a second frequency of a second array of transducers used to generate the sound speed rendering. ### Claim 11 (depends on 1) The method of claim 1, wherein generating the sound speed rendering comprises generating a plurality of acoustomechanical parameter slices associated with a plurality of coronal slices through the volume of tissue. ### Claim 12 (depends on 1) The method of claim 1, wherein the sound speed rendering is complex-valued and comprises a real portion corresponding to a sound speed, and an imaginary portion corresponding to a sound attenuation. ### Claim 13 (depends on 1) The method of claim 1, wherein generating the sound speed rendering comprises generating an initial sound speed rendering based on simulated waveforms according to a time travel tomography algorithm, and wherein the initial sound speed rendering is iteratively optimized until ray artifacts are reduced to a threshold. ### Claim 14 (depends on 13) The method of claim 13, wherein the simulated waveforms are optimized for each of a plurality of sound frequency components. ### Claim 15 (depends on 1) The method of claim 1, wherein generating the second reflection rendering comprises calculating a gradient of the sound speed rendering. ### Claim 16 (depends on 15) The method of claim 15, wherein calculating the gradient comprises performing one or more algorithms selected from the group consisting of the Sobel-Feldman operator, the Scharr operator, the Prewitt operator, and the Roberts Cross operator. ### Claim 17 (depends on 15) The method of claim 15, wherein calculating generating a second reflection rendering comprises performing computational relations selected from the group consisting of averaging, truncation, normalization, smoothing, addition, subtraction, multiplication, and division. ### Claim 18 (depends on 17) The method of claim 17, wherein smoothing comprises convolution with another function, adjacent averaging, or Fourier filtering. ### Claim 19 (depends on 1) The method of claim 1, wherein rendering the one or more combined images comprises performing an element-wise average or a weighted average of the first reflection rendering and the second reflection rendering. ### Claim 20 (depends on 19) The method claim 19, wherein rendering the one or more combined images comprises performing computational relations on the first reflection rendering or the second reflection rendering, the computational relations selected from the group consisting of averaging, truncation, normalization, smoothing, addition, subtraction, multiplication, and division. ### Claim 21 (depends on 1) The method of claim 1, wherein rendering the one or more combined images comprises performing an element-wise sum or a weighted sum of the first reflection rendering and the second reflection rendering. ### Claim 22 (depends on 21) The method of claim 21, wherein rendering the one or more combined images comprises performing computational relations on the first reflection rendering or the second reflection rendering, the computational relations selected from the group consisting of averaging, truncation, normalization, smoothing, addition, subtraction, multiplication, and division. ### Claim 23 (depends on 1) The method of claim 1, wherein rendering the one or more combined images comprises performing an element-wise product or a weighted product of the first reflection rendering and the second reflection rendering. ### Claim 24 (depends on 23) The method of claim 23, wherein rendering the one or more combined images comprises performing computational relations on the first reflection rendering or the second reflection rendering, the computational relations selected from the group consisting of averaging, truncation, normalization, smoothing, addition, subtraction, multiplication, and division. ### Claim 25 (depends on 1) The method of claim 1, wherein rendering the one or more combined images comprises performing a convolution of the first reflection rendering and the second reflection rendering. ### Claim 26 (depends on 25) The method of claim 25, wherein rendering the one or more combined images comprises performing computational relations on the first reflection rendering or the second reflection rendering, the computational relations selected from the group consisting of averaging, truncation, normalization, smoothing, addition, subtraction, multiplication, and division. ### Claim 27 (depends on 1) The method of claim 1, further comprising classifying, based on the one or more combined images, different types of lesions in the volume of tissue as at least one of a cancerous tumor, a fibroadenoma, a cyst, a nonspecific benign mass, and an unidentifiable mass. ### Claim 28 (depends on 1) A non-transitory computer-readable storage medium with instructions stored thereon that, when executed by a processor, cause a processor to perform the method of claim 1.