# US 10,368,819 B2 · Stenosis assessment > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,368,819 B2 - Document ID: US10368819B2 - Status: Granted - Kind: B2 - Application number: 15/326,509 - Filed: 2015-07-13 - Published: 2018-07-26 - Granted: 2019-08-06 - Earliest claimed: 2014-07-18 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Michael Grass; Roland Proksa - Web page: https://patentgrep.com/patent/US10368819B2 ## CPC - A61B 6/5217: {extracting a diagnostic or physiological parameter from medical diagnostic data} - A61B 6/032: {Transmission computed tomography [CT]} - A61B 6/481: {involving the use of contrast agents} - A61B 6/487: {involving fluoroscopy} - A61B 6/504: {for diagnosis of blood vessels, e.g. by angiography} - A61B 6/507: {for determination of haemodynamic parameters, e.g. perfusion CT} - G06T 7/0012: {Biomedical image inspection} - G06T 7/0016: {involving temporal comparison} - G06T 7/68: of symmetry - G16H 50/50: for simulation or modelling of medical disorders - G06T 2207/10081: Computed x-ray tomography [CT] - G06T 2207/10116: X-ray image - G06T 2207/30101: Blood vessel; Artery; Vein; Vascular - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract The present invention relates to improved assessment of a stenosis in a blood vessel in a body by comparing hemodynamic properties of the stenosed blood vessel with a substantially symmetric different blood vessel in the same body. ## Claims ### Claim 1 A method for assessing a stenosis in a blood vessel in a body, said body comprising a first blood vessel comprising a stenosis; and a second blood vessel that is substantially symmetric to the first blood vessel, said method comprising the steps of: imaging the first blood vessel and second blood vessel simultaneously to obtain image data of the first blood vessel and image data of the second blood vessel; determining hemodynamic properties relating to a section of the second blood vessel corresponding to a section of the first blood vessel comprising the stenosis from the image data of the second blood vessel, determining hemodynamic properties relating to the section of the first blood vessel comprising the stenosis from the image data of the first blood vessel; and generating stenosis data based on the determined hemodynamic properties relating to the section of the first blood vessel comprising the stenosis and on the determined hemodynamic properties relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis. ### Claim 2 (depends on 1) The method according to claim 1, wherein the hemodynamic properties relating to the section of the first blood vessel comprising the stenosis are determined at least partly from determined hemodynamic properties relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis. ### Claim 3 (depends on 1) The method according to claim 1, wherein symmetry information between the first blood vessel and second blood vessel is determined on a per slice basis and the section of the second blood vessel corresponding to a section of the first blood vessel comprising the stenosis is selected based on said determined symmetry information. ### Claim 4 (depends on 1) The method according to claim 1, wherein one or more hemodynamic properties are selected from a group comprising fractional flow reserve, blood pressure drop and stenotic resistance. ### Claim 5 (depends on 1) The method according to claim 1, wherein the imaging is non-invasive imaging from a group comprising: a computed tomography x-ray imaging, a 2D x-ray angiography or a C-arm x-ray imaging. ### Claim 6 (depends on 1) The method according to claim 1, wherein the first and second blood vessels part are a set of leg blood vessels, a set of arm blood vessels, a set of carotid arteries or a set of iliac arteries. ### Claim 7 (depends on 1) The method according to claim 1, wherein hemodynamic properties are determined by using a hemodynamic property model that is based on computational fluid dynamics simulation of blood flow in at least the first blood vessel. ### Claim 8 (depends on 7) The method according to claim 7, wherein the hemodynamic property model for determining hemodynamic properties relating to a section of the first blood vessel comprising the stenosis is based on input parameters including 3D segmentation of the image data and structural data of the first blood vessel derived therefrom and boundary conditions at inlets and outlets the first blood vessel and wherein said input parameters are at least partly based on properties derived from the image data relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis. ### Claim 9 (depends on 1) The method according to claim 1, wherein at least the determined hemodynamic properties relating to the section of the first blood vessel comprising the stenosis are displayed with respect to the relative length of the vessel. ### Claim 10 (depends on 9) The method according to claim 9, wherein the determined hemodynamic properties relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis are displayed, wherein the determined hemodynamic properties relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis is displayed mirrored. ### Claim 11 (depends on 1) The method according to claim 1, further comprising displaying the determined hemodynamic properties relating to the section of the first blood vessel comprising the stenosis and displaying the determined hemodynamic properties with respect to the relative length of the vessel. ### Claim 12 (depends on 11) The method according to claim 11, further comprising displaying the determined hemodynamic properties relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis and displaying the determined hemodynamic properties relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis mirrored. ### Claim 13 A system for assessing stenosis severity in a blood vessel in a body, said body comprising a first blood vessel comprising a stenosis; and a second blood vessel that is substantially symmetric to the first blood vessel, said system comprising an imaging system configured to simultaneously generate image data of the first blood vessel and the second blood vessel; and a processor configured to: determine hemodynamic properties relating to a section of the first blood vessel comprising the stenosis from image data of the first blood vessel; and determine hemodynamic properties relating to a section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis from the image data of the second blood vessel, and generate stenosis data based on the determined hemodynamic properties relating to the section of the first blood vessel comprising the stenosis and on the determined hemodynamic properties relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis. ### Claim 14 (depends on 13) The system according to claim 13, wherein the imaging system is a non-invasive imaging system from a group consisting of a computed tomography x-ray imaging device, a 2D x-ray angiography or a C-arm x-ray imaging device. ### Claim 15 A computer program product for assessing a stenosis in a first blood vessel in a body, said body comprising the first blood vessel comprising the stenosis and a second blood vessel that is substantially relative symmetric to the first blood vessel, said computer program product comprising instructions to execute the following steps when the computer program product is run on the computer; imaging the first blood vessel and second blood vessel simultaneously to obtain image data of the first blood vessel and image data of the second blood vessel; determining hemodynamic properties relating to a section of the second blood vessel corresponding to a section of the first blood vessel comprising the stenosis from the image data of the second blood vessel, determining hemodynamic properties relating to the section of the first blood vessel comprising the stenosis from the image data of the first blood vessel; and generating stenosis data based on the determined hemodynamic properties relating to the section of the first blood vessel comprising the stenosis and on the determined hemodynamic properties relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis. ### Claim 16 (depends on 15) The computer program product according to claim 15, wherein the computer program product further comprising instructions to execute the following steps: determining hemodynamic properties relating to the section of the first blood vessel comprising the stenosis at least partly from determined hemodynamic properties relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis. ### Claim 17 (depends on 15) The computer program product according to claim 15, wherein the computer program product further comprising instructions to execute the following steps: determining symmetry information between the first blood vessel and second blood vessel on a per slice basis and the section of the second blood vessel corresponding to a section of the first blood vessel comprising the stenosis is selected based on said determined symmetry information. ### Claim 18 (depends on 15) The computer program product according to claim 15, wherein the computer program product further comprising instructions to execute the following steps: selecting one or more hemodynamic properties from a group comprising fractional flow reserve, blood pressure drop and stenotic resistance. ### Claim 19 (depends on 15) The computer program product according to claim 15, wherein the computer program product further comprising instructions to execute the following steps: determining hemodynamic properties by using a hemodynamic property model that is based on computational fluid dynamics simulation of blood flow in at least the first blood vessel. ### Claim 20 (depends on 19) The computer program product according to claim 19, wherein the hemodynamic property model for determining hemodynamic properties relating to a section of the first blood vessel comprising the stenosis is based on input parameters including 3D segmentation of the image data and structural data of the first blood vessel derived therefrom and boundary conditions at inlets and outlets the first blood vessel and wherein said input parameters are at least partly based on properties derived from the image data relating to the section of the second blood vessel corresponding to the section of the first blood vessel comprising the stenosis.